Neuromagnetic measurements of the human primary auditory response

Hashimoto, Isao; Mashiko, T.; Yoshikawa, Kazuyoshi; Mizuta, T.; Imada, Toshiaki; Hayashi, Minoru

doi:10.1016/0168-5597(95)00004-c

Cited by 24 publications

(6 citation statements)

References 15 publications

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“…However, a few single AI neurons have minimum latencies of 30 -40 ms, i.e., near the estimates of transmission delays for P50m. Hence, these data are compatible with the suggestion that P50m originates in the human primary auditory cortex, though likely not in the input layers, and N100m in the planum temporale (Hashimoto et al 1995;Pantev et al 1990;Pellizone et al 1987). Figure 8C shows for the single-neuron data a plot of APP max(0) , resulting from the same fits, against stimulus/characteristic frequency.…”

Section: Figsupporting

confidence: 84%

Parallels Between Timing of Onset Responses of Single Neurons in Cat and of Evoked Magnetic Fields in Human Auditory Cortex

Biermann

Heil

2000

Journal of Neurophysiology

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Sound onsets constitute particularly salient transients and evoke strong responses from neurons of the auditory system, but in the past, such onset responses have often been analyzed with respect to steady-state features of sounds, like the sound pressure level. Recent electrophysiological studies of single neurons from the auditory cortex of anesthetized cats have revealed that the timing and strength of onset responses are shaped by dynamic stimulus properties at their very onsets. Here we demonstrate with magnetoencephalography that stimulus-response relationships very similar to those of the single neurons are observed in two onset components, N100m and P50m, of auditory evoked magnetic fields (AEFs) from the auditory cortex of awake humans. In response to tones shaped with cosine-squared rise functions, N100m and P50m peak latencies vary systematically with tone level and rise time but form a rather invariant function of the acceleration of the envelope at tone onset. Hence N100m and P50m peak latencies, as well as peak amplitudes, are determined by dynamic properties of the stimuli within the first few milliseconds, though not necessarily by acceleration. The changes of N100m and P50m peak latencies with rise time and level are incompatible with a fixed-amplitude threshold model. The direct comparison of the neuromagnetic and single-neuron data shows that, on average, the variance of the neuromagnetic data is larger by one to two orders of magnitude but that favorable measurements can yield variances as low as those derived from neurons with mediocre precision of response timing. The striking parallels between the response timing of single cortical neurons and of AEFs provides a stronger link between single neuron and population activity.

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Section: Figsupporting

confidence: 84%

Parallels Between Timing of Onset Responses of Single Neurons in Cat and of Evoked Magnetic Fields in Human Auditory Cortex

Biermann

Heil

2000

Journal of Neurophysiology

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“…However, subsequent studies with the magnetic correlate of N19, referred to as N19m, or Nam, have yielded conflicting results regarding the detectability of this component. While some authors identified the N19m in all subjects tested (Hashimoto et al, 1995;Kuriki et al, 1995;Rupp et al, 2000;Borgmann et al, 2001), Yoshiura et al (1995) only observed the wave in one of their seven subjects. Moreover, neither the six subjects in the study by Yvert et al (2001) nor the nine subjects in the study by Mä kelä et al (1994) 1 nor the four subjects in the study by Godey et al (2001) showed a clear N19m response.…”

Section: Introductionmentioning

confidence: 96%

Localization of Primary Auditory Cortex in Humans by Magnetoencephalography

et al. 2003

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“…Direct electric recordings indicate the earliest cortical response at 10 ms [Brugge et al, 2008;Celesia, 1976]. An early 11-ms response has been detected by MEG [Kuriki et al, 1995], followed by a deflection at 19 ms [Hashimoto et al, 1995;Scherg et al, 1990]. More robust middle-latency responses peak around 30-50 ms. Their generator sites are close to that of the strong, long-latency N100m response [Mäkelä et al, 1994;Pelizzone et al, 1987;Yvert et al, 2001]; however, they differ in sensitivity to stimulus manipulations.…”

Section: Introductionmentioning

confidence: 98%

Sources of auditory brainstem responses revisited: Contribution by magnetoencephalography

Parkkonen

Fujiki

Mäkelä

2009

Human Brain Mapping

126

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Auditory brainstem responses provide diagnostic value in pathologies involving the early parts of the auditory pathway. Despite that, the neural generators underlying the various components of these responses have remained unclear. Direct electrical recordings in humans are possible only in limited time periods during surgery and from small regions of the diseased brains. The evidence of the generator sites is therefore fragmented and indirect, based strongly on lesion studies and animal models. Source modeling of EEG has been limited to grand averages across multiple subjects. Here, we employed magnetoencephalography (MEG) to shed more light on the neural origins of the auditory brainstem responses (ABR) and to test whether such deep brain structures are accessible by MEG. We show that the magnetic counterparts of the electric ABRs can be measured in 30 min and that they allow localization of some of the underlying neural sources in individual subjects. Many of the electric ABR components were present in our MEG data; however, the morphologies of the magnetic and electric responses were different, indicating that the MEG signals carry information complementary to the EEG data. The locations of the neural sources corresponding to the magnetic ABR deflections ranged from the auditory nerve to the inferior colliculus. The earliest cortical responses were detectable at the latency of 13 ms.

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Neuromagnetic measurements of the human primary auditory response

Cited by 24 publications

References 15 publications

Parallels Between Timing of Onset Responses of Single Neurons in Cat and of Evoked Magnetic Fields in Human Auditory Cortex

Parallels Between Timing of Onset Responses of Single Neurons in Cat and of Evoked Magnetic Fields in Human Auditory Cortex

Localization of Primary Auditory Cortex in Humans by Magnetoencephalography

Sources of auditory brainstem responses revisited: Contribution by magnetoencephalography

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