Neuroma in Bilateral Upper Limb Amputation

Soroush, Mansoor; Modirian, Ehsan; Soroush, M; Masoumi, Maryam

doi:10.3928/01477447-20081201-26

Cited by 17 publications

(17 citation statements)

References 8 publications

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“…Both ultrasound and magnetic resonance imaging have been shown effective in identifying suspected neuromas . Studies that utilize only clinical judgement in the diagnosis of neuroma may not reflect accurate rates of formation, and may explain an overestimation of neuroma in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of symptomatic neuroma has only been described in populations affected by trauma. Recorded incidence ranges from 12% to 48% after lower limb amputation, 25% to 26% after upper limb amputation and 8% after digit amputation . Dysvascularity secondary to chronic metabolic disease is an increasingly common cause of lower limb amputation, with rates of neuroma not investigated in these cohorts.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and associations of painful neuroma in a contemporary cohort of lower‐limb amputees

Penna

Konstantatos

Cranwell

et al. 2018

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence and associations of painful neuroma in a contemporary cohort of lower‐limb amputees

Penna

Konstantatos

Cranwell

et al. 2018

ANZ Journal of Surgery

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“…Painful neuromas can be problematic after upper extremity amputation and multiple surgical approaches have been described to treat symptomatic cases [ 17 , 18 ]. Many surgeons choose to excise the distal neuroma bulb and implant the nerve into muscle [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb

Urbanchek

Kung

Frost

et al. 2016

BioMed Research International

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Background. The purpose of this experiment was to develop a peripheral nerve interface using cultured myoblasts within a scaffold to provide a biologically stable interface while providing signal amplification for neuroprosthetic control and preventing neuroma formation. Methods. A Regenerative Peripheral Nerve Interface (RPNI) composed of a scaffold and cultured myoblasts was implanted on the end of a divided peroneal nerve in rats (n = 25). The scaffold material consisted of either silicone mesh, acellular muscle, or acellular muscle with chemically polymerized poly(3,4-ethylenedioxythiophene) conductive polymer. Average implantation time was 93 days. Electrophysiological tests were performed at endpoint to determine RPNI viability and ability to transduce neural signals. Tissue samples were examined using both light microscopy and immunohistochemistry. Results. All implanted RPNIs, regardless of scaffold type, remained viable and displayed robust vascularity. Electromyographic activity and stimulated compound muscle action potentials were successfully recorded from all RPNIs. Physiologic efferent motor action potentials were detected from RPNIs in response to sensory foot stimulation. Histology and transmission electron microscopy revealed mature muscle fibers, axonal regeneration without neuroma formation, neovascularization, and synaptogenesis. Desmin staining confirmed the preservation and maturation of myoblasts within the RPNIs. Conclusions. RPNI demonstrates significant myoblast maturation, innervation, and vascularization without neuroma formation.

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“…Approximately one-quarter of upper-extremity amputees struggle with painful neuromas, which impede postoperative rehabilitation and long-term prosthetic use. 24,25 Major peripheral nerves are often managed by traction neurectomy at the time of primary amputation. Unfortunately, painful neuromas may develop as a result of disorganized fibroblast and Schwann cell proliferation.…”

Section: Targeted Muscle Reinnervation For Management Of Painful Neuromasmentioning

confidence: 99%

Current Concepts in Upper-Extremity Amputation

Pierrie¹,

Gaston

Loeffler

2018

The Journal of Hand Surgery

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Advances in motor vehicle safety, trauma care, combat body armor, and cancer treatment have enhanced the life expectancy and functional expectations of patients with upper-extremity amputations. Upper-extremity surgeons have multiple surgical options to optimize the potential of emerging prosthetic technologies for this diverse patient group. Targeted muscle reinnervation is an evolving technique that improves control of myoelectric prostheses and can prevent or treat symptomatic neuromas. This review addresses current strategies for the care of patients with amputations proximal to the wrist with an emphasis on recent advancements in surgical techniques and prostheses.

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Neuroma in Bilateral Upper Limb Amputation

Cited by 17 publications

References 8 publications

Incidence and associations of painful neuroma in a contemporary cohort of lower‐limb amputees

Incidence and associations of painful neuroma in a contemporary cohort of lower‐limb amputees

Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb

Current Concepts in Upper-Extremity Amputation

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