Neurological soft signs in euthymic bipolar I patients: A comparative study with healthy siblings and controls

Mrad, Ali Ben; Krir, Mohamed Wassim; Ajmi, Inès; Gaha, L.; Mechri, A.

doi:10.1016/j.psychres.2015.11.047

Cited by 27 publications

(14 citation statements)

References 44 publications

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“…The sample of this study showed a mean age at onset of the disorder of 31.8 years, which is consistent with other studies [19][20][21]. This, together with the mean duration of illness of 4.7 years and frequent hospitalization, gives an idea about the burden of this disease on the patients and their families especially their caregivers [22,23].…”

Section: Discussionsupporting

confidence: 90%

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Safy

Masry

Shabrawy

et al. 2020

Middle East Curr Psychiatry

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Background: Neurological soft signs in remitted state of bipolar disorder may represent trait deficits and the aim of this study was to examine the extent of neurological soft signs in euthymic patients with bipolar I disorder as compared to healthy controls. We conducted this study in Zagazig University Hospital upon 60 subjects divided into two groups: euthymic patients with bipolar I disorder group (30 patients) and control group (30 healthy individuals). Assessment of neurological soft signs was performed through Neurological Evaluation Scale and the euthymic state was determined by Young Mania Rating Scale and Hamilton Depression Rating Scale. Results: The euthymic patient group exhibited a significantly worse performance in the total Neurological Evaluation Scale and the whole four subtest scores than healthy control subjects. There was a statistically significant association between total neurological soft sign score and mood stabilizer therapy in the studied patients. The age of onset of the disorder was correlated to the total score of Neurological Evaluation Scale which is statistically significant. The best cutoff points of the total neurological soft signs score in the discrimination between the euthymic patient group and control group was 3.5 according to the receiver operating characteristic curve. Conclusion: This study may emphasize the role of neurological soft signs as a sign of organic brain disorder; however, further studies may be able to extend our findings to explore the etiology and pathogenesis of bipolar I disorder.

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Section: Discussionsupporting

confidence: 90%

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Safy

Masry

Shabrawy

et al. 2020

Middle East Curr Psychiatry

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“…Such problematic composition of study samples is probably behind a series of results suggesting that healthy controls do not differ from unaffected relatives of mental patients. In such a study on Bipolar patients the prevalence of NSS in the control group was much higher in comparison to the current study (Sharma et al, 2016; Mrad et al, 2016). Such high prevalence rates and scores are reported by other studies also (Dazzan et al, 2006) and as previously argued, they are probably the result of contamination of the study sample.…”

Section: Discussioncontrasting

confidence: 83%

Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?

Fountoulakis

Panagiotidis

Kimiskidis

et al. 2018

Intl J of Devlp Neuroscience

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“…NSS are minor neurological abnormalities that include motor, sensory, and inhibitory dysfunctions 73 . Previous studies found an increase in NSS in BD patients 73–75 but not in MDD patients 73 . Taken together, the impairment of the cerebello-thalamo-prefrontal pathway may cause dysfunction of information transmission and functional integration, which may bring about NSS in BD.…”

Section: Discussionmentioning

confidence: 73%

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

Wang

Jia

et al. 2017

Sci Rep

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Identifying brain differences and similarities between bipolar disorder (BD) and major depressive disorder (MDD) is necessary for increasing our understanding of the pathophysiology and for developing more effective treatments. However, the features of whole-brain intrinsic functional connectivity underlying BD and MDD have not been directly compared. We collected resting-state fMRI data from 48 BD patients, 48 MDD patients, and 51 healthy subjects. We constructed voxel-wise whole-brain functional networks and computed regional functional connectivity strength (FCS) using graph-theory and further divided the regional FCS into long-range FCS (lFCS) and short-range FCS (sFCS). Relative to the controls, both the BD and MDD patients showed decreased sFCS in the bilateral precuneus. In addition, the BD patients showed increased and the MDD patients showed decreased lFCS and sFCS in the bilateral cerebellum. The BD patients also showed increased lFCS in the right middle temporal gyrus and increased sFCS in the bilateral thalamus compared to either the MDD patients or the controls. These findings suggest that BD and MDD may have some shared as well as a greater number of specific impairments in their functional connectivity patterns, providing new evidence for the pathophysiology of BD and MDD at the large-scale whole brain connectivity level.

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Neurological soft signs in euthymic bipolar I patients: A comparative study with healthy siblings and controls

Cited by 27 publications

References 44 publications

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Neurological soft signs for discrimination between euthymic patients with bipolar I disorder and healthy controls

Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?

Shared and Specific Intrinsic Functional Connectivity Patterns in Unmedicated Bipolar Disorder and Major Depressive Disorder

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