Neurological outcome after cardiac arrest: a prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

G, Ok; Aydın, Demet; Erbüyün, Koray; Gürsoy, Canan; Taneli, Fatma; Bilge, Sedat; Horasan, Gönül Dınç

doi:10.3906/sag-1503-64

Cited by 12 publications

(8 citation statements)

References 29 publications

(49 reference statements)

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“…Current laboratory parameters studied as prognostic factors include NSE, 23 S-100B, glial fibrillary acidic protein (GFAP), and soluble 100-β 3, 24 though these biomarkers are not available in every organization or produce erroneous prognostic estimation rates when used alone. 22 Procalcitonin is a parameter that is more easily accessible and more common in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management?

Zincircioğlu¹,

Yavuz²,

Sarıtaş³

et al. 2020

Indian Journal of Critical Care Medicine

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Objectives Although high procalcitonin (PCT) levels are associated with poor neurological outcomes and increased mortality rates in patients treated with targeted temperature management (TTM) in the postcardiac arrest (CA) period, there are limited data about the correlation between PCT levels and infection. The aim of our study was to assess the relationship of PCT levels in the first 48 hours with early period infections, late period neurological prognosis, and mortality in patients treated with TTM after CA. Materials and methods Serum PCT was measured on admission days 1 and 2. The early onset infection diagnosis before the seventh day in the intensive care unit (ICU) was made according to the criteria of infection centers for disease control and prevention. Mortality and neurologic outcomes were assessed 90 days after CA according to cerebral performance category (CPC) score. Results There was no statistically significant correlation between early period infection diagnosis and PCT levels at the time of admission, 24th, and 48th hours. Patients with poor neurologic outcomes on the 90th day had significantly high PCT levels at 24 ( p = 0.044) and 48 hours ( p = 0.004). There was no statistically significant correlation between admission PCT levels and neurological prognosis. While the correlation between mortality and PCT levels at 24 ( p = 0.049) and 48 ( p = 0.004) hours was significantly high, no statistically significant correlation was found between admission PCT levels and mortality. Conclusion In patients treated with TTM after CA, increased PCT levels were significantly correlated with poor neurologic outcomes and mortality. However, the elevated PCT levels were not significantly correlated with early period infections. How to cite this article Zincircioglu C, Yavuz T, Sarıtaş A, Çakmak M, Güldoğan IK, Uzun U, et al. Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management? Indian J Crit Care Med 2020;24(5):327–331.

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Section: Discussionmentioning

confidence: 99%

Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management?

Zincircioğlu¹,

Yavuz²,

Sarıtaş³

et al. 2020

Indian Journal of Critical Care Medicine

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“…PCT is an inflammatory marker present in the pathogenesis of severe complications such as sepsis or organ failure. Recent studies have demonstrated the role of PCT in neurotrauma that is caused by TBI or resuscitation [5,7]. When inflammatory process is triggered, messenger ribonucleic acid synthesized by calcitonin I gene is upregulated, giving rise to increasing PCT levels within a two to three-hour period.…”

Section: Discussionmentioning

confidence: 99%

Prognostic performance of optic nerve sheath diameters in CT images and serum procalcitonin levels in traumatic brain injury patients in the intensive care unit: A retrospective cohort study

Gürsoy¹,

Gürsoy²,

Demirbilek³

2019

Journal of Surgery and Medicine

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“…Our result was similar to the previous clinical study in that patients with a better Glasgow outcome scale had lower serum levels of GFAP. 44 However, Zakarya et al 45 showed the opposite result: rats had better behavioral test scores but represented higher GFAP staining intensity.…”

Section: F I G U R Ementioning

confidence: 99%

Selective brain perfusion improves the neurological outcomes after extracorporeal cardiopulmonary resuscitation in a rat model

Chang,

Hsu,

Lee

et al. 2024

Artificial Organs

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BackgroundThe major concern in patients who have suffered from cardiac arrest (CA) and undergone successful extracorporeal cardiopulmonary resuscitation (E‐CPR) is poor neurological outcomes. In this study, we aimed to introduce a rat model of selective brain perfusion (SBP) during E‐CPR to improve the neurological outcome after CA.MethodsThe rats underwent 7 min of untreated asphyxial CA and then were resuscitated with E‐CPR for 30 min. The right external jugular vein and right femoral artery were separately cannulated to the E‐CPR outflow and inflow. The right common carotid artery was cannulated from the proximal to the distal side for SBP. Subsequently, rats were removed from E‐CPR, wounds were closed, and 90 min of intensive care were provided. Neurological deficit scores were tested after 4 h of recovery when the rats were mechanical ventilation‐free. S100 calcium‐binding protein B (S100B) and glial fibrillary acidic protein (GFAP) were detected through immunohistochemistry (IHC) of brain tissue.ResultsThe rats that received SBP while resuscitated by E‐CPR showed markedly better neurological performances after 4‐h recovery than those resuscitated by E‐CPR only. The IHC staining of GFAP and S100B in the hippocampus was low in the rats receiving SBP during E‐CPR, but only GFAP showed significant differences.ConclusionsWe successfully developed a novel and reproducible rat model of SBP while resuscitated by E‐CPR to ameliorate the neurological performances after CA. This achievement might have opportunities for studying how to improve the neurological outcome in the clinical condition.

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Neurological outcome after cardiac arrest: a prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

Abstract: In predicting neurological outcomes, serum S-100B has high sensitivity and low specificity immediately after CPR.

Cited by 12 publications

References 29 publications

Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management?

Is Procalcitonin a Marker of Neurologic Outcome or Early Infection in Patients Treated with Targeted Temperature Management?

Prognostic performance of optic nerve sheath diameters in CT images and serum procalcitonin levels in traumatic brain injury patients in the intensive care unit: A retrospective cohort study

Selective brain perfusion improves the neurological outcomes after extracorporeal cardiopulmonary resuscitation in a rat model

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