Neurological manifestations by sex and age group in COVID-19 inhospital patients

Pereira, Daniella Nunes; Bicalho, Maria Aparecida Camargos; Jorge, Alzira de Oliveira; Gomes, Angélica Gomides dos Reis; Schwarzbold, Alexandre Vargas; Araújo, Anna Luiza Homan; Cimini, Christiane Corrêa Rodrigues; Ponce, Daniela; Rios, Danyelle Romana Alves; Grizende, Genna Maira Santos; Manenti, Euler Roberto Fernandes; Anschau, Fernando; Aranha, Fernando Graça; Bartolazzi, Frederico; Batista, Joanna d'Arc Lyra; Tupinambás, Julia Teixeira; Ruschel, Karen Brasil; Ferreira, Maria Angélica Pires; Paraíso, Pedro Gibson; Araújo, Silvia Ferreira; Teixeira, Antônio Lúcio; Marcolino, Milena Soriano

doi:10.1016/j.ensci.2022.100419

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…The Brazilian COVID Registry Project, a multicenter study that collected data from 39 Brazilian hospitals in 17 cities, observed that patients admitted with COVID-19 and clinically diagnosed with neurological syndromes had a higher incidence of septic shock, ICU admission and death compared to controls [70]. Furthermore, the study separated neurological manifestations presented at hospital admission according to incidence by sex and age group and found that women were more likely to have headaches and less likely to have seizures [71]. In MHV-3 infection in females there was a reduction of BDNF and CX3CL1, which may result in behavioral changes and loss of protection mechanisms.…”

Section: Discussionmentioning

confidence: 99%

A suitable model to investigate acute neurological consequences of coronavirus infection

Pimenta,

Da Silva Oliveira,

Lima

et al. 2023

Inflamm. Res.

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Objective and design:The present study aimed to investigate the neurochemical and behavioral effects of the acute consequences after coronavirus infection through a murine model. Material:Wild type C57 BL/6 mice were infected intranasally (i.n) with the murine coronavirus 3 (MHV-3). Methods:Mice were submitted to behavioral tests. Euthanasia was performed on the fth day after infection (5 dpi), and the brain tissue was subjected to plaque assays for viral titration, synaptosome, ELISA, histopathological and immunohistochemical analysis. Results:Increased viral titers associated with mild histological changes, including signs of neuronal degeneration, were observed in the cerebral cortex of infected mice. Importantly, MHV-3 infection induced an increase in cortical levels of glutamate and calcium, as well as increased levels of pro-in ammatory cytokines (IL-6, IFN-γ) and reduced levels of neuroprotective mediators (BDNF and CX3CL1) in the mice brain, which is suggestive of excitotoxicity. Finally, behavioral analysis showed impaired motor, anhedonic and anxietylike behaviors in animals infected with MHV-3. Conclusions:Overall, the data presented emulate many aspects of the acute neurological outcomes seen in patients with COVID-19. Therefore, this model may provide a preclinical platform to study acute neurological sequelae induced by coronavirus infection and test possible therapies.

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Section: Discussionmentioning

confidence: 99%

A suitable model to investigate acute neurological consequences of coronavirus infection

Pimenta,

Da Silva Oliveira,

Lima

et al. 2023

Inflamm. Res.

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show abstract

“…In addition, the elderly population is at higher risk of developing adverse complications than their peers (Bonanad et al, 2020 ; Tiruneh et al, 2021 ). Delirium, syncope, and coma are more likely in the elderly than in younger patients with COVID-19, while the incidence of loss of smell, hearing loss, and headache decreases with age (Pereira et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical profile, treatment, and outcomes of patients with COVID-19 in a tertiary referral hospital in South Sumatera, Indonesia: A retrospective single-center study

et al. 2022

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Background: Although there are fewer COVID-19 cases in Indonesia, the pandemic is still ongoing. COVID-19 has a significant death rate in Indonesia, but lack of information on the effect of different clinical and demographic factors on COVID-19-related grimness and mortality in Indonesia. Objective: This study examined the clinical profile, treatment, and outcomes of patients with COVID-19 at Lahat Regency Hospital in South Sumatera, Indonesia, to find relevant markers that might be utilized to predict the prognosis of these patients. Methods: This was a retrospective single-center study of all medical record files of confirmed patients with COVID-19 admitted to Lahat Hospital from September 2020 to August 2021 (n = 285). Descriptive statistics, Chi-square, Mann-Whitney, Multiple Logistic Regression, and Cox's proportional hazards model were used for data analyses. Results: This study included 65 non-hospitalized and 220 hospitalized patients. Hospitalized patients were divided into dead and alive groups. The median age was lower in the non-hospitalized group without gender discrimination, and most hospitalized patients had comorbidities. Vital signs and clinical features were significantly different in hospitalized patients compared to non-hospitalized. The survival patients in the hospitalized group showed lower white blood cell (WBC), neutrophil percentages, and neutrophil-lymphocyte ratio (NLR) but higher lymphocyte and eosinophil. Non-survival patients had elevated alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, blood glucose, and potassium. The use of Favipiravir and Remdesivir was significant between the alive and dead groups. The mean hospital stay for all patients was 9.49 ± 4.77 days, while the median duration of hospital time was 10.73 ± 4.33 days in the survival group and 5.39 ± 3.78 days in the non-survival group. Multiple logistic regression analysis determined respiration rate, WBC, and BUN as predictors of survival. Conclusions: Age and comorbidities are significant elements impacting the seriousness of COVID-19. Abnormal signs in laboratory markers can be used as early warning and prognostic signs to prevent severity and death. Potential biomarkers at various degrees in patients with COVID-19 may also aid healthcare professionals in providing precision medicine and nursing.

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“…21 31 Yapılan bir çalışmalarda yaşlı COVID-19 hastalarının, genç hastalara kıyasla daha yüksek deliryum, senkop ve koma prevalansı sergilediği ve ileri yaşın, deliryum ve koma riskini artırdığı ileri sürülmüştür. 32 Pandeminin ilk olarak çıktığı Çin'in verilerine müstenit bir çalışmada COVID-19 tanısı ile hastaneye yatış oranlarının yaşla birlikte yükseldiği, 20 ila 29 yaş için %1, 50 ila 59 yaş için %4 ve 80 yaşından büyükler için %18 olduğu raporlanmıştır. 33 Salgın süresince yayınlanan araştırmalarda COVID-19 pandemisi büyük çoğunluğu yaşlı olmakla beraber kronik hastalığı olanları da olumsuz etkilediği öne sürülmektedir.…”

Section: Introductionunclassified

Kronik Hastalığı Olan Bireylerin COVID-19 Korkusu ve Kronik Hastalıklara Uyumları Arasındaki İlişki

ATAMAN BOR,

YURTÇİÇEK EREN,

YILDIRIM

2023

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

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Araştırma, kronik hastalığı olan bireylerin COVID-19 korkusu ve kronik hastalıklara uyumları arasındaki ilişkiyi belirlemek amacıyla planlandı. Tanımlayıcı tipte olan araştırmanın, evrenini Hakkari İli'nde yaşayan en az bir kronik hastalığı olan bireyler, örneklemini ise kolayda örnekleme yöntemi ile araştırmacıların kendi sosyal medya hesaplarına ekli en az 1 kronik hastalığı olan gönüllü 419 birey oluşturdu. Etik kurul izni alınan çalışmada veriler, Kişisel Tanıtıcı Bilgi Formu, COVID-19 Korkusu Ölçeği (COVID-19 KÖ) ile Kronik Hastalıklara Uyum Ölçeği (KHUÖ) kullanılarak toplandı. Araştırmadaki bireylerin yaş ortalaması 32,35±17,45, %59,4'si kadındır. Katılımcıların %41,8'i nörolojik, kalp damar ve kanser gibi hastalıklarının olduğunu, %24,3'ü kendileri ve %75,5'i yakınlarının COVID-19 geçirdiğini bildirdi. Yine katılımcıların COVID-19 KÖ puan ortalaması 19,10±7,53 ve KHUÖ puan ortalaması 73,75±18,85’tir. Katılımcıların yaşı arttıkça COVID-19 korkusunda da anlamlı bir artış olduğu saptandı. Kadınların COVID-19 KÖ ve KHUÖ fiziksel uyum alt boyut puan ortalamasının erkeklere göre anlamlı düzeyde yüksek olduğu bulundu (p

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Neurological manifestations by sex and age group in COVID-19 inhospital patients

Cited by 6 publications

References 42 publications

A suitable model to investigate acute neurological consequences of coronavirus infection

A suitable model to investigate acute neurological consequences of coronavirus infection

Clinical profile, treatment, and outcomes of patients with COVID-19 in a tertiary referral hospital in South Sumatera, Indonesia: A retrospective single-center study

Kronik Hastalığı Olan Bireylerin COVID-19 Korkusu ve Kronik Hastalıklara Uyumları Arasındaki İlişki

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