Neurological Disease in Cattle in Southern Brazil Associated with Bovine Herpesvirus Infection

Abstract

Abstract. The occurrence of neurological disease in cattle caused by Bovine herpesvirus in 11 farms from southern Brazil between 1987 and 2007 is described. Twenty-two animals were necropsied. Major clinical signs included excessive salivation, nasal and ocular discharge, circling, recumbency, depression, incoordination, grinding of teeth, and paddling movements. Necropsy findings in 10 of 22 cattle included hyperemia and softening of the rostral portions of the telencephalic cortex, with flattening of gyri, and malacia. Cattle in 10 cases did not show any gross lesions. Histological examination in most cases revealed nonsuppurative and necrotizing meningoencephalitis with acute neuronal necrosis, edema, eosinophilic intranuclear inclusion bodies in astrocytes and neurons, and infiltration of gitter cells. No histologic lesions could be detected in 4 cases. The initial diagnosis was based upon the clinical, epidemiological, and pathological findings. The diagnosis was confirmed by virus isolation in cell culture followed by virus identification by a glycoprotein Cbased polymerase chain reaction. Seven isolates were identified as Bovine herpesvirus 5, and 4 were identified as Bovine herpesvirus 1.

Abordagem diagnóstica das principais doenças do sistema nervoso de ruminantes e equinos no Brasil

“…Os principais dados epidemiológicos e clínico-patológicos dessas doenças estão nos Quadros 1-4 e nas Figuras 1-18. Para uma descrição detalhada de cada doença o leitor pode acessar as publicações correspondentes às doenças de bovinos (Sanches et al 2000, Langohr et al 2003,b,c, Rodrigues et al 2005a, 2007, 2008b, Sant'Ana et al 2009a,b, Lucena et al 2010, ovinos (Rissi et al 2008a(Rissi et al ,c, 2010a, caprinos (Rissi et al 2006b) e equinos (Barros et al 1984, Rodrigues et al 2005b, Pierezan et al 2007). Como ocorre em qualquer sistema, para o diagnóstico das doenças do SN é necessário um histórico epidemioló-gico e clínico completo e, quando for o caso, uma completa descrição dos achados macroscópicos.…”

Construction and growth properties of bovine herpesvirus type 5 recombinants defective in the glycoprotein E or thymidine kinase gene or both

“…Neurological diseases by alpha-herpesviruses in cattle have been described in many parts of the world but the incidence is notably higher in Argentina and Brazil (2,4). In these countries, BoHV-1-based vaccines have been increasingly used in the last decades, and only a few vaccines have been formulated that contain both BoHV-1 and BoHV-5 strains.…”

“…E-mail: flores@ccr.ufsm.br Bovine herpesvirus type 5 (BoHV-5) is a neurovirulent alpha-herpesvirus associated with necrotizing meningoencephalitis in cattle (1). BoHV-5 infection has been occasionally described in several countries including Australia, the United States and European countries, while the disease is more prevalent in South American countries such as Brazil and Argentina (2)(3)(4)(5). BoHV-5 is closely related to another important alpha-herpesvirus of cattle, bovine herpesvirus type 1 (BoHV-1), the agent of infectious bovine rhinotracheitis and infectious pustular vulvovaginitis/balanoposthitis, also associated with abortion (1).…”

PCR Multiplex para detecção dos principais herpesvírus neurológicos de ruminantes

“…O BoHV-1 pode causar danos neurológicos, ainda que esse não seja um fenômeno comum (Brower et al, 2008;Rissi et al, 2008). Essa ocorrência rara foi demonstrada em dois estudos que trabalharam com diagnóstico molecular por PCR.…”