Neurological Complications of the Reticuloses

Neurological Disorders Associated with Malignant Disease

“…Victor, Banker and Adams (1958) described five cases of demyelinating polyneuropathy associated with multiple myeloma and found that it resembled sensory-motor carcinomatous neuropathy. Cameron, Howell and Hutchison (1958) described demyelination of the peripheral nerves in Hodgkin's disease, as did Hutchinson, Leonard, Maudsley and Yates (1958), who also found demyelination in the spinal cord. Cerebral disorders associated with demyelination in Hodgkin's disease and lymphatic leukimia were reported by Astrom, Mancall and Richardson (1958) and Cavanagh, Greenbaum, Marshall and Rubinstein (I959) and in lymphosarcoma by Lloyd and Urich (1959).…”

Lymphoma-associated dysimmune polyneuropathies

“…The frequency of GBS may be slightly higher in HL compared to NHL [1,3], and probably relates to the persistent defect in cellular immunity with relatively intact humoral immune responses common to patients with HL [63]. A retrospective study assessed the neurological complications in 229 patients with the "reticuloses" (a group of disorders characterized by the usually malignant proliferation of any of the cells of the reticuloendothelial system) [64]: 4 patients were diagnosed with peripheral neuropathy (2 severe; 2 mild) without evidence of a primary demyelinating process on post-mortem examination (reported on 3 patients). Another retrospective study of the non-metastatic neurological syndromes "of obscure origin" in 774 patients with the "reticuloses", established 5 cases of peripheral neuropathy in patients with HL, lymphosarcoma and CLL: resolved GBS was reasonably diagnosed in 1 patient with HL in remission [65].…”

Involvement of the nervous system in malignant lymphoma in Nigeria.

“…Lesions in the central nervous system were found in North American cases of malignant lymphoma resembling the African variety (Dorfman, 1965). The lesions in both the African and North American cases are like those known to occur in lymphomas in general, and particularly in lymphosarcoma (Allison and Gordon, 1955;Browder and de Veer, 1939;Burstein, Kernohan and Uihlein, 1963;Critchley and Greenfield, 1930;Gordon, 1957;Hutchinson et al, 1958;Moore et al, 1960;Russell and Rubinstein, 1963;Sparling, Adams and Parker, 1947;Whisnant, Sickert and Sayre, 1956;and Williams et al, 1951).…”