Neurological complications in a predominantly African American sample of COVID-19 predict worse outcomes during hospitalization

Abstract

Highlights The most common neurological chief complaint in patients with COVID-19 is Altered Mental Status. A neurological chief complaint at admission is associated with prolonged hospital stays, death, and intubation. Altered Mental Status at admission is associated with significantly prolonged hospital stay. Patients with Altered Mental Status during the hospital stay, as well as those who had seizures, were more likely to require intubation.

Comorbidities in SARS-CoV-2 Patients: a Systematic Review and Meta-Analysis

“…In a cohort of COVID-19 patients with neurological complaints, altered mental status was identified as an independent predictor of prolonged hospital stay with an OR of 1.6 (95% CI, 1.1 to 2.5; P = 0.01) and the requirement for intubation with an OR of 4.9 (95% CI, 2.6 to 9.4; P , 0.0001) (32).…”

“…Of the three studies, only cancer with an OR of 6.51 (95% CI, 1.72 to 24.64; P = 0.006) was reported as an independent risk factor for a severe outcome in a study with participants from China (25). In a Spanish cohort of 456 SARS-CoV-2-positive rheumatic and nonrheumatic patients, connective tissue disorder with an OR of 1.64 (95% CI, 1.02 to 2.66; P = 0.042), obesity with an OR of 1.78 (95% CI, 1.13 to 2.81; P = 0.013), diabetes with an OR of 1.81 (95% CI, 1.11 to 2.95; P = 0.018), hypertension with an OR of 2.60 (95% CI, 1.72 to 3.94; P , 0.001), heart failure with an OR of [26], and Chachkhiani et al [32]). N is the study size, n is the number of participants with comorbidity, and Log.HR is the natural logarithm of hazard ratio.…”

“…The overall natural logarithm of hazard ratio (log.HR) of mortality in patients with [28], and Chachkhiani et al [32]). N is the study size, n is the number of participants with comorbidity, and Log.HR is the natural logarithm of hazard ratio.…”

“…Independent risk factors for mortality were reported in 22 studies, and these risk factors included hypertension, obesity, diabetes, renal disease, chronic obstructive pulmonary disease (COPD), neurological disease, and cardiovascular disease (18, 26, 30-37, 40, 42-52). Eight studies were selected for meta-analysis of cancer (36,39), chronic kidney diseases (26,28,39), diabetes (26,28,32,53), hypertension (26,32,53), and obesity (28,37) as comorbidities. Meta-analysis results for comorbidities in which three or more studies were included in the analysis are shown in Fig.…”

COVID-19 infection produces subarachnoid hemorrhage; acting now to understand its cause: A short communication

“…The novel coronavirus disease 2019 (COVID-19) is a global pandemic with international concern [ 1 ]. SAH is a devastating disease [ 2 ], which accounts for approximately 5–10 % of strokes [ 2 ] Several case report about the SAH and COVID-19 infection have been reported [ [3] , [4] , [5] , [6] ], but three reviews about the interaction between COVID-19 and the central nervous system have been recently published, but the occurrence of SAH in patients with Covid-19 infection has not been mentioned in these reviews [ [7] , [8] , [9] ].…”