COVID-19 outcomes of 10,881 patients: retrospective study of neurological symptoms and associated manifestations (Philippine CORONA Study)

Espiritu, Adrian I.; Sy, Marie Charmaine C.; Anlacan, Veeda Michelle M.; Jamora, Roland Dominic G.; Macalintal, Corina Maria Socorro A.; Robles, Joanne B; Cataniag, Paulo L.; Flores, Manolo Kristoffer C.; Tangcuangco-Trinidad, Noreen Jhoanna C.; Juangco, Dan Neftalie; Paas, Giuliani Renz G.; Chua, Audrey Marie U.; Estrada, Valmarie S.; Mejia, Philip Rico P.; Reyes, Therese Franz B.; Cañete, Maria Teresa A.; Zapata, Ferdinand Renfred A.; Castillo, Franko Eugenio B.; Esagunde, Romulo U.; Gantioque, Jean B.; Abbariao, Maritoni C.; Acebuque, Geramie M.; Corral, Evram V.; Escasura, Marian Irene C.; Ong, Marissa; Fowler, Krizelle Cleo; Pineda, Arnold Angelo M.; Aradani, Khasmeen D.; Catindig, Joseree-Ann S.; Cinco, Mark Timothy T.; Ramos, Mark Erving H.; Cruz, Rhodieleen Anne R. de la; Dantes, Marita; Francisco, Norberto A.; Teleg, Rosalia A.; Bellosillo, Krisverlyn B.; Delfino, Jean Paolo M.; Diesta, Cid Czarina E.; Espiritu-Picar, R.; Gamboa, Julie Anne V.; Matute, Cara Camille M.; Padilla, Franzelle P.; Punsalan, John Joshua Q.; Collantes, Ma. Epifania V; Que, Charmaine B.; Sampao, Hanifa A.; Maria, Maxine Camela S. Sta.; Fuentes, Marita M.; Manzano, J J; Umali, Rizza J.; Molina, Marc Conrad C.; Minerva-Ang, Hazel Claire; Surdilla, Arturo F.; Talabucon, Loreto Pascual; Wabe, Natasha F.; Manuel, Maria; Pajantoy, Al Inde John A.; Roque, Josephine Cecilia V.; Yambao, Paul Emmanuel L.; Banday, Christian Paul B.; Cipriano, Chritopher C.; Pangandaman, Nehar A.; Wasil, Avery Gail C.; Inocian, Elrey P.; Vatanagul, J.; Apor, Almira Doreen Abigail O.; Dioquino, Carissa Paz C.; Cruz, Prinz Andrew M. Dela; Yumul, Maricar P.; Carandang-Concepcion, Ma. Alma E.; Desquitado, Ma. Caridad V.; Julao, Carl Kevin L.; Bornales, Dante P.; Maylem, Generaldo D.; Cuntapay, Mark Joseph F.; Lao-Reyes, Annabelle Y.; Lee, Aileen Mae B.; Manlegro, Nadia O.; Pelere, Dave Mar L.; Laxamana, Lina C.; Que, Diana-Lynn S.; Yu, Jeryl Ritzi T.; Martinez, Marvin; Matic, Alexandria E.; Perez, John Angelo Luigi S.; Constantino, Glenn Anthony A.; Olano, Aldanica R.; Quiles, Liz Edenberg P.; Roxas, Artemio; Soliven, Jo Ann R.; Montojo-Tamayo, Michael Dorothy Frances; Joson, Ma. Lourdes C.; Evangelista, Jojo R.; Nuñez, Ma. Clarissa B.; Olaivar, Marietta C.; Perez, Dominique Q.; Armeña, Mark Deneb O.; Barja, Robert A.; Abejero, Joshua Emmanuel E.; Eribal, Maritzie R.; Alava, Ryndell G.; Kalbi, Muktader A.; Radja, Nasheera W.; Sali, Mohammad Elshad S.

doi:10.1007/s00702-021-02400-5

Cited by 27 publications

(25 citation statements)

References 55 publications

(55 reference statements)

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“…We performed an analysis of patients diagnosed with DM based on the data from a nationwide, multicenter, comparative, retrospective, cohort study involving patients with COVID-19 who were admitted to our hospitals/study sites from February 2020 until December 2020 23 , 24 . All methods were carried out in accordance with relevant guidelines.…”

Section: Methodsmentioning

confidence: 99%

“…The Philippine CORONA ( C OVID-19 Outcomes: a R etrospective study Of N eurological manifestations and A ssociated symptoms) study encompassed a total of 37 major hospitals/study sites from various regions in the Philippines (see Appendix 2 ) 23 , 24 .…”

Section: Methodsmentioning

confidence: 99%

“…We included all patients analyzed in The Philippine CORONA Study 23 , 24 . Patients with DM were identified through history of having diabetes mellitus diagnosed using any of the following criteria: fasting blood glucose of ≥ 126 mg/dL, hemoglobin A1c (HbA1c) of ≥ 6.5% and random blood sugar of ≥ 200 mg/dL in the presence of symptoms of hyperglycemia.…”

Section: Methodsmentioning

confidence: 99%

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The outcomes of patients with diabetes mellitus in The Philippine CORONA Study

Espiritu

Chiu

et al. 2021

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Patients diagnosed with diabetes mellitus (DM) who are infected with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) belong to the most vulnerable patient subgroups. Emerging data has shown increased risks of severe infections, increased in ICU admissions, longer durations of admission, and increased mortality among coronavirus disease 2019 (COVID-19) patients with diabetes. We performed a subgroup analysis comparing the outcomes of patients diagnosed with DM (n = 2191) versus patients without DM (n = 8690) on our data from our study based on a nationwide, comparative, retrospective, cohort study among adult, hospitalized COVID-19 patients involving 37 hospital sites from around the Philippines. We determined distribution differences between two independent samples using Mann–Whitney U and t tests. Data on the time to onset of mortality, respiratory failure, intensive care unit (ICU) admission were used to build Kaplan–Meier curves and to compute for hazard ratios (HR). The odds ratios (OR) for longer ventilator dependence, longer ICU stay, and longer hospital stays were computed via multivariate logistic regression. Adjusted hazard ratios (aHR) and ORs (aOR) with 95% CI were calculated. We included a total of 10,881 patients with confirmed COVID-19 infection (2191 have DM while 8690 did not have DM). The median age of the DM cohort was 61, with a female to male ratio of 1:1.25 and more than 50% of the DM population were above 60 years old. The aOR for mortality was significantly higher among those in the DM group by 1.46 (95% CI 1.28–1.68; p < 0.001) as compared to the non-DM group. Similarly, the aOR for respiratory failure was also significantly higher among those in the DM group by 1.67 (95% CI 1.46–1.90). The aOR for developing severe COVID-19 at nadir was significantly higher among those in the DM group by 1.85 (95% CI 1.65–2.07; p < 0.001). The aOR for ICU admission was significantly higher among those in the DM group by 1.80 (95% CI 1.59–2.05) than those in the non-DM group. DM patients had significantly longer duration of ventilator dependence (aOR 1.33, 95% CI 1.08–1.64; p = 0.008) and longer hospital admission (aOR 1.13, 95% CI 1.01–1.26; p = 0.027). The presence of DM among COVID-19 patients significantly increased the risk of mortality, respiratory failure, duration of ventilator dependence, severe/critical COVID-19, ICU admission, and length of hospital stay.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The outcomes of patients with diabetes mellitus in The Philippine CORONA Study

Espiritu

Chiu

et al. 2021

Sci Rep

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“…A large cohort study found 6 cases of GBS among 10,881 new-onset neurological complications associated with COVID-19. 1 The reported prevalence (approximately 0.06%) was higher than that observed in the general population (typically 0.001% to 0.004%). A case report also described a patient with facial diplegia, which occurred 2 weeks after SARS-CoV-2 infection.…”

mentioning

confidence: 79%

“…One negative impact of this disease is the neurological dysfunctions that can result from SARS-CoV-2 infection, in addition to respiratory problems. One in 20 patients with COVID-19 complains of neurological complications, 1 but whether COVID-19 provokes or triggers neurological problems remains unclear. There is a need for thorough research into the correlation between COVID-19 and neurological disorders.…”

mentioning

confidence: 99%