Neurological and related syndromes in CNS tuberculosis Clinical features and pathogenesis

Udani, P. M.; U, Parekh; Dastur, Darab K.

doi:10.1016/0022-510x(71)90222-x

Cited by 137 publications

(58 citation statements)

References 7 publications

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“…Patients with tuberculomas rarely have symptoms of primary tuberculosis, such as fever, weight loss, and loss of appetite, because the absence of toxaemia is associated with an inability of the wall of a tuberculoma to permit absorption (2,12). Tuberculomas may occur in any part of the nervous system due to the haematogenous spread of the tuberculous bacillus.…”

Section: Discussionmentioning

confidence: 99%

Tuberculoma in the Medulla Oblongata and Medulla Spinalis:Two Case Reports

Gülşen¹,

Caner²

2013

Balkan Med J

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Section: Discussionmentioning

confidence: 99%

Tuberculoma in the Medulla Oblongata and Medulla Spinalis:Two Case Reports

Gülşen¹,

Caner²

2013

Balkan Med J

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“…HIV-positive patients with tuberculoma are more likely to experience seizures than HIV-negative patients [86]. Acute seizures occur in half of pediatric cases and in 5% of adult cases of TBM [87]. Patients with seizures have a worse prognosis [6].…”

Section: Specific Antituberculous Treatmentmentioning

confidence: 99%

Tuberculous Meningitis in Adults: A Review of a Decade of Developments Focusing on Prognostic Factors for Outcome

2012

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Tuberculous meningitis (TBM) is the most severe form of TB. Despite treatment, mortality and long-term disability remain unacceptably high. Prevention, early recognition, diagnosis and treatment are fundamental to improving outcomes. However, an effective vaccine remains elusive, initial symptoms are nonspecific, and sensitive diagnostic tests are not available. There has been progress in our understanding of the immunopathology of TBM, and several factors have been found to be associated with susceptibility to infection, disease progression and clinical outcome. However, these have not yet impacted on treatment. Early treatment initiation and uninterrupted continuation, severity on presentation, seizures, stroke, cranial nerve involvement, cerebrospinal fluid cell count and lactate levels, hyponatreamia and coinfection with HIV are all found to be important prognostic factors for outcome. Pathogen lineage (Beijing genotype) and host genetics (polymorphisms in TLR2, TIRAP and LTA4H genes) can influence susceptibility to TBM. However, these findings have not yet impacted on treatment. Progress in vaccine development, opportunities for better diagnostic tests, novel insights into pathogenesis and an increasing evidence base for improving treatment should impact the current high mortality and morbidity, if translated to global and local guidelines.

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“…Also, serum cysticercosis antibodies were positive and brain MRI showed disseminated granulomas. Multiple tuberculous mycobacterial infections, such as intracranial tuberculoma, are often observed in immunocompromised or in older patients (5). However, the present patient was middle-aged with a normal immune status, with lesions in the lateral and fourth ventricles.…”

Section: Discussionmentioning

confidence: 54%

Disseminated Intracranial Tuberculoma Mimicking Neurocysticercosis

Zhang

Qiu

2011

Intern. Med.

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Intracranial tuberculoma and neurocysticercosis (NCC) are the most frequent granulomatous infections in the central nervous system. Here we report a 41-year-old man with disseminated intracranial tuberculoma mimicking NCC. The patient complained of relapsing vertigo and vomiting consistent with Bruns syndrome. Serum antibodies against cysticercosis were positive. Magnetic resonance imaging (MRI) of the brain showed multiple disseminated ring-enhanced lesions. An initial diagnosis of NCC was made based on clinical signs and MRI. However, during antiparasitic treatment, the patient exhibited fever, meningitis signs, and positive cerebrospinal fluid findings for tuberculosis. The diagnosis was therefore corrected as tuberculoma. After three months of antituberculous treatment, the patient recovered clinically and on MRI. Our results highlight the importance of differential diagnosis of these two diseases in the early stage.

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Neurological and related syndromes in CNS tuberculosis Clinical features and pathogenesis

Cited by 137 publications

References 7 publications

Tuberculoma in the Medulla Oblongata and Medulla Spinalis:Two Case Reports

Tuberculoma in the Medulla Oblongata and Medulla Spinalis:Two Case Reports

Tuberculous Meningitis in Adults: A Review of a Decade of Developments Focusing on Prognostic Factors for Outcome

Disseminated Intracranial Tuberculoma Mimicking Neurocysticercosis

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