Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization

Abstract

The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.

Circulating CD34-Positive Cells Have Prognostic Value for Neurologic Function in Patients with past Cerebral Infarction

“…*P < 0.05 versus patients with decreased levels of circulating CD34 + cells. Similar to the correlation between mobilization of CD34 + cells and improved myocardial function after a coronary ischemic event (Wojakowski et al, 2006), mobilization of circulating CD34 + cells has been shown to correlate with functional recovery during the acute phase of cerebral infarction (Dunac et al, 2007;Yip et al, 2008). Our report herein shows a relationship between increased levels of CD34 + cells and improved functional outcome even in the extensive phase after stroke.…”

Circulating CD34-Positive Cells Provide a Marker of Vascular Risk Associated with Cognitive Impairment

“…In contrast, in our study, although there was no strong correlation between levels of CD34 + cells and established cardiovascular risk factors and other treatments, probably because of the heterogeneity of our control subjects, the results indicate a close relationship between the overall CD34 + pool and the cognitive impairment with cerebral ischemia. Previous reports have indicated a positive correlation between mobilization of CD34 + cells and improved functional outcome in stroke patients (Dunac et al, 2007). Accelerated functional recovery after experimental stroke, because of administration of CD34 + cells (Shyu et al, 2006;Taguchi et al, 2004b), suggests the possible contribution of CD34 + cells in maintenance of brain function during cerebral circulation.…”

The Therapeutic Potential of Stimulating Endogenous Stem Cell Mobilization

“…For example, the number of PBSC in stroke patients nearly tripled within 7 days after the stroke (Hennemann et al, 2008;Paczkowska et al, 2005). In one study, the magnitude of stem cell release was actually correlated with the functional recovery of the patients (Dunac et al, 2007). Interestingly, the number of circulating stem cells did not increase in patients who received thrombolysis therapy immediately after their stroke.…”

“…Studies have shown that the number of PBSC in stroke patients can increase up to 3-fold within 7 days after the stroke (Hennemann et al, 2008;Paczkowska et al, 2005). In one study, the magnitude of BMSC mobilization was correlated with the patients' functional recovery (Dunac et al, 2007).…”