The Therapeutic Potential of Stimulating Endogenous Stem Cell Mobilization

Drapeau, Christian; Eufemio, George; Mazzoni, Paola; Roth, Gerhard; Strandberg, Susan

doi:10.5772/26455

Cited by 8 publications

(5 citation statements)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, increasing the number of circulating stem cells has been documented to enhance tissue repair or to improve the course of disease formation in cases of acute myocardial infarction,93,94 stroke,95 bone fracture,96 muscle injury,97 spinal cord injury,98 diabetic wound healing,99 and inner ear damage,100 to name a few. Stem cell mobilization using an extract of the cyanophyta species Aphanizomenon flos-aquae was documented to improve cases of severe cardiomyopathy, stroke, diabetes, rheumatoid arthritis, kidney failure, and Parkinson’s disease 62. An extract of Rehmannia glutinosa was also shown to trigger stem cell mobilization via a CXCR4-dependent mechanism and to improve the outcome of myocardial infarction 101.…”

Section: Discussionmentioning

confidence: 99%

Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects

Drapeau¹,

Benson

Jensen

2019

CIA

Self Cite

View full text Add to dashboard Cite

PurposeThe aim of this study was to evaluate the effects of a proanthocyanidin-rich extract of sea buckthorn berry (SBB-PE) on the numbers of various types of adult stem cells in the blood circulation of healthy human subjects.Study design and methodsA randomized, double-blind, placebo-controlled, cross-over trial was conducted in 12 healthy subjects. Blood samples were taken immediately before and at 1 and 2 hours after consuming either placebo or 500 mg SBB-PE. Whole blood was used for immunophenotyping and flow cytometry to quantify the numbers of CD45dim CD34+ CD309+ and CD45dim CD34+ CD309− stem cells, CD45− CD31+ CD309+ endothelial stem cells, and CD45− CD90+ mesenchymal stem cells.ResultsConsumption of SBB-PE was associated with a rapid and highly selective mobilization of CD45dim CD34+ CD309− progenitor stem cells, CD45− CD31+ CD309+ endothelial stem cells, and CD45− CD90+ lymphocytoid mesenchymal stem cells. In contrast, only minor effects were seen for CD45dim CD34+ CD309+ pluripotential stem cells.ConclusionConsumption of SBB-PE resulted in selective mobilization of stem cell types involved in regenerative and reparative functions. These data may contribute to the understanding of the traditional uses of SBB for preventive health, regenerative health, and postponing the aging process.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (Hippophae) in healthy human subjects

Drapeau¹,

Benson

Jensen

2019

CIA

Self Cite

View full text Add to dashboard Cite

show abstract

“…The same phenomenon has been documented after skin burn [9], bone fracture [10] and stroke [11]. Then following a signal from the affected tissue, circulating stem cells migrate in the tissue where they differentiate in cells of that tissue, participating to the process of tissue repair [12].…”

mentioning

confidence: 59%

Understanding the Natural Role of Stem Cells in the Body: A New Understanding of Disease Formation?

Drapeau¹

2013

J Stem Cell Res Ther

Self Cite

View full text Add to dashboard Cite

“…This data suggest that stem cell mobilization may be an important mechanism of action behind the health benefits of A. macroclada. spectra of health benefits were shown to act at least in part by supporting the mobilization of bone marrow stem cells into the peripheral blood circulation [5,6], thereby increasing the number of circulating stem cells available to participate to the process tissue repair [7]. In this study we investigated the effect of A. macroclada on stem cell mobilization, which would provide a mechanism of action for the various health benefits associated with A. macroclada.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Potential of Stimulating Endogenous Stem Cell Mobilization

Cited by 8 publications

References 192 publications

<p>Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (<em>Hippophae</em>) in healthy human subjects</p>

<p>Rapid and selective mobilization of specific stem cell types after consumption of a polyphenol-rich extract from sea buckthorn berries (<em>Hippophae</em>) in healthy human subjects</p>

Understanding the Natural Role of Stem Cells in the Body: A New Understanding of Disease Formation?

Aloe macroclada from Madagascar Triggers Transient Bone Marrow Stem Cell Mobilization

Contact Info

Product

Resources

About