Neurological and electroneuromyographic assessment of the adverse effects of acrylamide on occupationally exposed workers.

Fs, He; Sl, Zhang; Hl, Wang; G, Li; Zm, Zhang; Fl, Li; Dong, Xiao; Hu, Fung-Rong

doi:10.5271/sjweh.1878

Cited by 123 publications

(65 citation statements)

References 2 publications

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“…This finding is in contrast with the results of previous studies (18)(19)(20) on acrylamide exposure, which have rather consistently shown reduced amplitudes as a sign of axonal degeneration. When the large random variation in the amplitude measurements is considered, the intermittent NMA-acrylamide exposure over a relatively long time (2 years) may not have been sufficient for the detection of any effect on the amplitudes in such a small group of workers 4 months or more after the cessation of exposure.…”

Section: Discussioncontrasting

confidence: 99%

Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide

Kjuus¹,

Goffeng²,

Heier³

et al. 2004

Scand J Work Environ Health

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Section: Discussioncontrasting

confidence: 99%

Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide

Kjuus¹,

Goffeng²,

Heier³

et al. 2004

Scand J Work Environ Health

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“…He et al (1989) The AA exposed workers reported significantly more frequent symptoms like skin peeling from the hands, numbness in the hands and feet, lassitude, sleepiness, muscle weakness, clumsiness of the hands, anorexia, unsteady gait, coldness of hands and feet, difficulty in grasping and stumbling and falling. Electromyographic investigation revealed a decrease in the sensory action potential amplitude, prolonged duration of motor units and increased polyphasic potentials.…”

Section: Epidemiological Studies: Neurological Alterationsmentioning

confidence: 96%

Scientific Opinion on acrylamide in food

Publication¹

2015

EFS2

292

170

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EFSA was asked to deliver a scientific opinion on acrylamide (AA) in food. AA has widespread uses as an industrial chemical. It is also formed when certain foods are prepared at temperatures above 120 °C and low moisture, especially in foods containing asparagine and reducing sugars. The CONTAM Panel evaluated 43 419 analytical results from food commodities. AA was found at the highest levels in solid coffee substitutes and coffee, and in potato fried products. Mean and 95th percentile dietary AA exposures across surveys and age groups were estimated at 0.4 to 1.9 µg/kg body weight (b.w.) per day and 0.6 to 3.4 µg/kg b.w. per day, respectively. The main contributor to total dietary exposure was generally the category 'Potato fried products (except potato crisps and snacks)'. Preferences in home-cooking can have a substantial impact on human dietary AA exposure. Upon oral intake, AA is absorbed from the gastrointestinal tract and distributed to all organs. AA is extensively metabolised, mostly by conjugation with glutathione but also by epoxidation to glycidamide (GA). Formation of GA is considered to represent the route underlying the genotoxicity and carcinogenicity of AA. Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity were identified as possible critical endpoints for AA toxicity from experimental animal studies. The data from human studies were inadequate for dose-response assessment. The CONTAM Panel selected BMDL 10 values of 0.43 mg/kg b.w. per day for peripheral neuropathy in rats and of 0.17 mg/kg b.w. per day for neoplastic effects in mice. The Panel concluded that the current levels of dietary exposure to AA are not of concern with respect to non-neoplastic effects. However, although the epidemiological associations have not demonstrated AA to be a human carcinogen, the margins of exposure (MOEs) indicate a concern for neoplastic effects based on animal evidence. © European Food SUMMARYFollowing a request from the European Commission, the Panel on Contaminants in the Food Chain (CONTAM Panel) was asked to deliver a scientific opinion on acrylamide (AA) in food. The Panel developed the draft scientific opinion which underwent a public consultation from 1 July 2014 to 15 September 2014. The comments received and how they were taken into account when finalising the scientific opinion were published in an EFSA Technical Report (EFSA, 2015).AA is a low molecular weight, highly water soluble, organic compound. It is used inter alia as an industrial chemical and in the production of polyacrylamides. Heightened concerns about exposure to AA arose in 2002 when it was discovered that it forms when certain foods are prepared at temperatures usually above 120 °C and low moisture. It forms, at least in part, due to a Maillard reaction between certain amino acids, such as asparagine, and reducing sugars. However, several other pathways and precursors have also been proposed to contribute to AA formation. AA forms in numerous baked or fried carbohydrate-rich f...

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“…Though various toxic effects of acrylamide, (e.g., reproductive toxicity and possibly carcinogenicity) have been suggested by animal studies (171), the most relevant effect identified in humans is neurotoxicity, most notably a distal axonopathy (172)(173)(174).…”

Section: Acrqlamidementioning

confidence: 99%

Biomarker Research in Neurotoxicology: The Role of Mechanistic Studies to Bridge the Gap between the Laboratory and Epidemiological Investigations

Costa¹

1996

Environmental Health Perspectives

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There is an increasing interest in the development and validation of biomarkers for use in biochemical/molecular epidemiological studies. Though the area of neurotoxicology has received much attention in the past several years, it still lags behind with regard to the development of biomarkers, particularly those of health effects and susceptibility. This review discusses several aspects of biomarker research as it relates to neurotoxic compounds and focuses on selected agents (organophosphorus insecticides, styrene, n-hexane, carbon disulfide, acrylamide), which have been the subject of a number of investigations in animals and humans. While traditional biomonitoring approaches and novel techniques (e.g., hemoglobin adducts) provide several measurements for monitoring exposure to neurotoxic chemicals, potential markers of genetic susceptibility have been seldom investigated in a neurotoxicology context. Furthermore, the complexity of the nervous system, together with the multiplicity of end points and the limited knowledge of the exact mechanism(s) of action of neurotoxicants, has led to only limited advancements in the development of biomarkers for neurotoxic effects. Significant progress in this area will depend upon an increased understanding of the cellular, biochemical, and molecular targets directly involved in neurotoxicity. Environ Health Perspect 1 04(Suppl 1): 55-67 (1996)

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Neurological and electroneuromyographic assessment of the adverse effects of acrylamide on occupationally exposed workers.

Cited by 123 publications

References 2 publications

Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide

Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide

Scientific Opinion on acrylamide in food

Biomarker Research in Neurotoxicology: The Role of Mechanistic Studies to Bridge the Gap between the Laboratory and Epidemiological Investigations

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