Neurologic recovery and improved detrusor contractility using muscle-derived cells in rat model of unilateral pelvic nerve transection

Kwon, Dongdeuk; Minnery, Brandon S.; Kim, Yongtae; Kim, Jang Hwan; Miguel, Fernando de; Yoshimura, Naoki; Chancellor, Michael B.

doi:10.1016/j.urology.2005.01.037

Cited by 36 publications

(28 citation statements)

References 18 publications

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“…To date, MDSCs for the treatment of SUI have been studied by investigating the ability of stem cells to differentiate into mature cells. Injected MDSCs have been shown to enhance the regeneration and improve the contractility of injured detrusor muscles and the urethral sphincter [17][18][19][20][21][22] . Chermansky et al [23] showed that MDSCs integrated within the striated muscle layer of the cauterized urethra 4 weeks after MDSC injection increased LPP significantly compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation Enhances Closing Pressure and Leak Point Pressure in a Female Urinary Incontinence Rat Model

Kim¹,

Kwon³

et al. 2010

Urol Int

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Purpose: The purpose of this study was to determine whether periurethral injection of allogenic mesenchymal stem cells (MSCs) could increase the leak point pressure (LPP) in a rat model of stress urinary incontinence. Materials and Methods: Female Sprague-Dawley rats (230–240 g, n = 30) were divided into 3 groups: sham operation (group C), saline-treated (group S) and MSC-treated (group M). Bilateral pudendal nerve dissection followed by normal saline or MSC injection on both sides of the urethra was done. LPP and closing pressure (CP) testing was performed after the treatment. The specific markers for smooth muscle cells in the transplantation sites of the urethra were determined. Results: Both the LPP and CP were significantly lower in group S than controls. However, these were restored to the control values in group M (p < 0.05). The LPPs of groups C, S and M were 29.1 ± 2.1, 22.0 ± 2.2 and 43.1 ± 3.2 cm H₂O, respectively. The CPs of groups C, S and M were 27.1 ± 3.1, 21.1 ± 3.2, and 32.1 ± 2.1 cm H₂O, respectively. The injected MSCs stained positive for muscle-specific markers. Conclusion: This study suggests that MSCs might differentiate into muscle lineage cells and may contribute to the repair of damaged muscle tissue.

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Section: Discussionmentioning

confidence: 99%

Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation Enhances Closing Pressure and Leak Point Pressure in a Female Urinary Incontinence Rat Model

Kim¹,

Kwon³

et al. 2010

Urol Int

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“…Moreover, experimental injury of detrusor muscle and urethral sphincter has been successfully treated with stem cells injection as a potential therapy for urinary incontinence. [21][22][23][24][25][26] To our knowledge, no previous report on the use of stem cells for the treatment of anal incontinence is present in the surgical literature.…”

mentioning

confidence: 99%

Treatment of Experimental Injury of Anal Sphincters with Primary Surgical Repair and Injection of Bone Marrow-Derived Mesenchymal Stem Cells

Lorenzi¹,

Pessina²,

Lorenzoni³

et al. 2008

Diseases of the Colon &Amp; Rectum

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In our experimental model, bone marrow-derived mesenchymal stem cells injection improved muscle regeneration and increased contractile function of anal sphincters after injury and repair. Therefore, mesenchymal stem cells may represent an attractive tool for treating anal sphincter lesions in humans. Investigations into the biologic basis of this phenomenon should increase our knowledge on underlying mechanisms involved in sphincter repair.

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“…These cells can be isolated from many different sources such as bone marrow, muscle, adipose tissue, liver tissue, amniotic fluid, placenta, umbilical cord and dental pulp [16]. Table 1 summarizes the main animal studies which have been conducted in the last years using adult stem cells [17,18,19,20,21,22,23,24,25,26]. …”

Section: Stem Cell Therapymentioning

confidence: 99%

“…Other studies have shown the power of MDSCs to restore muscular contraction of the muscular sphincter and to recover the damaged pelvic nerves [21,22]. It has also been suggested that the formation of myotubes may activate intrinsic nerve regeneration and formation of the neuromuscular junction [23,27,28].…”

Section: Animal Studiesmentioning

confidence: 99%

Stem Cell Therapy for Male Urinary Incontinence

et al. 2012

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Introduction: Among the medical and surgical options which have been proposed in the last years for the management of male stress urinary incontinence (SUI), stem cell therapy represents a new frontier treatment. The aim of this paper is to update the current status of stem cell therapy in animal and human studies for the management of iatrogenic male SUI. Material and Methods: A PubMed review of the literature on stem cell therapy for the treatment of male SUI was performed. Results: Regarding animal studies, bone marrow-, muscle- and adipose-derived stem cells have been widely studied, showing regeneration of the urethral sphincter and recovery of the damaged pelvic nerves. With regard to human studies, only four papers are available in the literature using muscle- and adipose-derived stem cells which reported a significant improvement in sphincteric function and incontinence with no severe side effects. Conclusions: In spite of these promising results, further studies are needed with longer follow-ups and larger numbers of patients in order to clarify the potential role of stem cell therapy for the treatment of male SUI.

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Neurologic recovery and improved detrusor contractility using muscle-derived cells in rat model of unilateral pelvic nerve transection

Cited by 36 publications

References 18 publications

Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation Enhances Closing Pressure and Leak Point Pressure in a Female Urinary Incontinence Rat Model

Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation Enhances Closing Pressure and Leak Point Pressure in a Female Urinary Incontinence Rat Model

Treatment of Experimental Injury of Anal Sphincters with Primary Surgical Repair and Injection of Bone Marrow-Derived Mesenchymal Stem Cells

Stem Cell Therapy for Male Urinary Incontinence

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