Neurologic Involvement in Scleroderma en Coup de Sabre

Amaral, Tiago Nardi; Neto, João Francisco Marques; Lapa, Aline Tamires; Peres, Fernando Augusto; Guirau, Caio Rodrigues; Appenzeller, Simone

doi:10.1155/2012/719685

Cited by 39 publications

(33 citation statements)

References 47 publications

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“…Jednak w piśmiennictwie opisano pewną liczbę czynników wyzwalających, w tym uraz, szczepienie BCG (Bacille Calmette-Guérin), unieruchomienie kończyny, iniekcje In our case blunt trauma was the possible causative factor. En coup de sabre has been associated with a number of neurological abnormalities, usually preceded by the development of cutaneous disease by months to years, which include headache, epilepsy, focal neurologic deficits, movement disorders, neuropsychiatric symptoms and intellectual deterioration [4]. However, in our case no neurological involvement was observed clinically or radiologically.…”

contrasting

confidence: 51%

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Concomitant en coup de sabre and plaque type morphea in the same patient: a rare occurrence

Arif¹,

Adil²,

Amin³

et al. 2017

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contrasting

confidence: 51%

“…Zaburzenia te obejmują: ból głowy, padaczkę, ogniskowe deficyty neurologiczne, zaburzenia poruszania się, objawy neuropsychiatryczne i obniżenie sprawności intelektualnej [4]. W opisanym przypadku nie odnotowano jednak zajęcia układu nerwowego w badaniach klinicznych ani radiologicznych.…”

unclassified

Concomitant en coup de sabre and plaque type morphea in the same patient: a rare occurrence

Arif¹,

Adil²,

Amin³

et al. 2017

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“…This specific type of morphea is associated with neurological symptoms. 35 Cutis verticis gyrata is a descriptive term for a condition of the scalp consisting of deep grooves and convolutions that resemble the surface of the brain. Physical examination of the scalp shows cerebriform appearance with accentuating folds and deep furrows (cutis verticis gyrata), thickening in the face, frontal and parietal regions as observed in our patients also.…”

Section: Discussionmentioning

confidence: 99%

An overview of scalp dermatoses in a tertiary care institute

et al. 2020

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is a common disorder in Children that includes atopic dermatitis, seborrheic dermatitis, tinea capitis, and psoriasis. 1 In a survey of 735 adults in the United States, 39% experienced some flaking, and almost 50% complained of scalp itch. 2In human societies, hair and scalp now play an important role in appearance and sexual signalling; original functional roles of protection and heat conservation are secondary, and changes in the appearance of skin and hair, which affect self-esteem and confidence in social settings, have become primary. The good condition of the scalp has a considerable effect on the patient's psychological well-being and social interaction. The ABSTRACTBackground: The scalp is unique among skin areas in humans, with high follicular density and high rate of sebum production which though providing thermal insulation also creates an environment conducive to superficial mycotic infections and parasitic infestations. As there is a paucity of studies on scalp dermatoses in the Indian and Western literature, a clinical study of these scalp dermatoses can unravel the common clinico-epidemiological manifestations in our population. Methods: This is a prospective observational study conducted for a period of 6 months. All the patients reporting to our department were evaluated for entry into the study and patients having scalp lesions were enrolled. A detailed clinical history and a thorough scalp examination were performed. Results: The incidence of scalp dermatoses is more among adolescents and early adulthood with a male to female ratio 1.8:1. 57% of patients had lesions exclusive to scalp. Scalp was the initial site of presentation in 54.6% of cases who had generalized lesions. Itching (n=107; 53.5%) is the commonest presenting complaint. Among the scalp sites, parietal area was involved the most (73%). The most common dermatoses were psoriasis (21.5%) followed by alopecia areata (11.5%). Conclusions: The scalp dermatoses have significant psychological impact affecting the social profile of the patients. To the best of our knowledge, this is the first Indian study on scalp dermatoses involving all age groups which gives a precise clinical insight into scalp dermatoses.

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“…Our patients with SS and SSc had a good response to the treatment [19,[41][42][43]. The two patients with SCNSV due to WG and BD were resistant to treatment and died during the follow-up.…”

Section: Discussionmentioning

confidence: 99%

Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis

et al. 2014

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The objectives of this study are to compare the initial clinical, laboratory, and imaging features in primary central nervous system vasculitis (PCNSV) vs secondary central nervous system vasculitis (SCNSV) and follow up after treatment with intravenous cyclophosphamide (IV-CYC) plus glucocorticosteroids (GCS): methylprednisolone (MP). Neurological, laboratory, and neuroimaging findings were analyzed in PCNSV and SCNSV patients. Cerebral biopsy (CB) was performed in nine patients. Both groups received at onset MP plus IV-CYC for 6 months, followed by bimonthly IV-CYC plus prednisone (PND) for 12 months. All patients were followed during 36 months. Thirty patients were included (12 PCNSV and 18 SCNSV). Focal and non-focal neurological manifestations were similar in both groups, headache being the most frequent manifestation in both groups. Fatigue, myalgias, arthralgias, neuropathy, low leukocytes and platelets, elevated erythrocyte sedimentation rate, positive antinuclear antibodies (ANA), anti-double-stranded DNA (dsDNA), antineutrophil cytoplasmic antibodies (ANCA), low complement, and rheumatoid factor were more frequent in SCNSV (p < 0.05). In cerebrospinal fluid, pleocytosis and proteins were higher in PCNSV (p < 0.05). Periventricular and subcortical hyperintense lesions were observed in cranial magnetic resonance imaging in both vasculitides. Cerebral angiography and angioresonance showed narrowing of vasculature in all patients in both groups. CB showed gliosis and lymphocytic infiltration within and around the walls in four patients and granulomatous infiltration in the other patients. After treatment, the Kaplan-Meier survival curve showed a higher relapse-free survival in PCNSV (p < 0.05). Neurological manifestations and neuroimaging findings were similar in both groups of vasculitides, but general symptoms, joint, musculoskeletal, and peripheral neuropathy were preponderant in SCNSV. After treatment with IV-CYC and GCS, patients with PCNSV had a higher relapse-free survival than those with SCNSV.

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Neurologic Involvement in Scleroderma en Coup de Sabre

Cited by 39 publications

References 47 publications

Concomitant en coup de sabre and plaque type morphea in the same patient: a rare occurrence

Concomitant en coup de sabre and plaque type morphea in the same patient: a rare occurrence

An overview of scalp dermatoses in a tertiary care institute

Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis

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