Neurologic disorders of mineral metabolism and parathyroid disease

Agrawal, Lily; Habib, Zeina; Emanuele, Nicholas V.

doi:10.1016/b978-0-7020-4087-0.00049-8

Cited by 14 publications

(18 citation statements)

References 65 publications

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“…This case presents a unique challenge of determining causation and correlation in a patient with psychosis, an eating disorder, and persistent electrolyte abnormalities. Electrolyte disturbances, regardless of etiology, can cause and/or contribute to neuropsychiatric symptoms (Agrawal, Habib, & Emanuele, 2014). Confounding symptoms presented unique challenges in this case.…”

Section: Discussionmentioning

confidence: 81%

A causality dilemma: ARFID, malnutrition, psychosis, and hypomagnesemia

Wassenaar

O’Melia

Mehler

2018

Intl J Eating Disorders

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We present a novel case of a woman with coincident occurrence of auditory and visual hallucinations, electrolyte disturbances, chloride unresponsive alkalosis, and an eating disorder. The patient was ultimately diagnosed with Gitelman syndrome comorbid with schizophreniform disorder and avoidant restrictive food intake disorder. Eating disorders are often associated with electrolyte abnormalities which, in turn, can cause or contribute to other neuropsychiatric symptoms. At the same time, psychotic disorders can lead to food intake aversions or overconsumption of fluids with associated effects on electrolyte balance. In this case, a third factor, Gitelman syndrome, resulted in persistent hypomagnesemia with metabolic alkalosis and, while separate from her eating disorder, simultaneously reinforced the patient's strong food preferences, excessive fluid intake, and excessive movement related to her complaints of persistent joint pain.

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Section: Discussionmentioning

confidence: 81%

A causality dilemma: ARFID, malnutrition, psychosis, and hypomagnesemia

Wassenaar

O’Melia

Mehler

2018

Intl J Eating Disorders

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“…Hypoparathyroidism may result in hypocalcemia causing muscular pain, cramp, numbness, stiffness, tetany, apnea, and seizures. In addition, increased intracranial pressure with headaches and vomiting may occur 17 , 37 , 39) . Autoimmune polyendocrine syndrome type 1 (APS1) was reported in two siblings who presented hypocalcemic seizure followed by hypoparathyroidism 40) .…”

Section: Neurologic Findings In Specific Endocrine Disordersmentioning

confidence: 99%

“…Hyperparathyroidism may cause hypercalcemia which leads to muscular weakness, anorexia, nausea, vomiting, and encephalopathy 17 , 37 , 39) . Polydipsia, polyuria, weight loss, headache, seizure, and psychiatric symptoms may occur in this condition 17 , 37 , 39) . Although primary hyperparathyroidism is not common in children, severe central nervous system and metabolic derangement may develop.…”

Section: Neurologic Findings In Specific Endocrine Disordersmentioning

confidence: 99%

Endocrine disorders and the neurologic manifestations

2014

Ann Pediatr Endocrinol Metab

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The nervous system and the endocrine system are closely interrelated and both involved intimately in maintaining homeostasis. Endocrine dysfunctions may lead to various neurologic manifestations such as headache, myopathy, and acute encephalopathy including coma. It is important to recognize the neurologic signs and symptoms caused by the endocrine disorders while managing endocrine disorders. This article provides an overview of the neurologic manifestations found in various endocrine disorders that affect pediatric patients. It is valuable to think about 'endocrine disorder' as a cause of the neurologic manifestations. Early diagnosis and treatment of hormonal imbalance can rapidly relieve the neurologic symptoms. Better understanding of the interaction between the endocrine system and the nervous system, combined with the knowledge about the pathophysiology of the neurologic manifestations presented in the endocrine disorders might allow earlier diagnosis and better treatment of the endocrine disorders.

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“…8,10,11 Neurologic manifestations are mainly cognitive and neuromuscular in nature and range from personality changes, to lack of concentration, memory impairment, and, in severe cases, lethargy and coma. 12 Other rarely reported neurologic manifestations include PRES. 7,8 The most common cause of hypercalcemia is primary hyperparathyroidism either due to parathyroid adenoma, or due to malignancies, granulomatous diseases and iatrogenic causes.…”

mentioning

confidence: 99%

“…7,8 The most common cause of hypercalcemia is primary hyperparathyroidism either due to parathyroid adenoma, or due to malignancies, granulomatous diseases and iatrogenic causes. 12 Therefore, the diagnosis of PRES in the setting of hypercalcemia requires a high level of suspicion.…”

mentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome: A Case of Hypercalcemia

et al. 2018

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RESUMOA síndrome de encefalopatia posterior reversível corresponde a uma encefalopatia que pode caracterizar-se clinicamente por cefaleia, alteração do estado de consciência e/ou crises epiléticas. A neuroimagem geralmente revela edema vasogénico subcortical bilateral occipito-parietal reversível. A fisiopatologia permanece por esclarecer mas frequentemente associa-se a hipertensão, insuficiência renal, sépsis e uso de terapêutica imunossupressora. O seu desenvolvimento no contexto de hipercalcémia severa é extremamente raro. Os autores apresentam um caso de síndrome de encefalopatia posterior reversível numa doente normotensa com hipercalcemia severa como etiologia mais provável.

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Neurologic disorders of mineral metabolism and parathyroid disease

Cited by 14 publications

References 65 publications

A causality dilemma: ARFID, malnutrition, psychosis, and hypomagnesemia

A causality dilemma: ARFID, malnutrition, psychosis, and hypomagnesemia

Endocrine disorders and the neurologic manifestations

Posterior Reversible Encephalopathy Syndrome: A Case of Hypercalcemia

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