Neurologic Aspects of Waldenström's Macroglobulinemia

Logothetis, John

doi:10.1001/archneur.1960.00450050084010

Cited by 123 publications

(34 citation statements)

References 19 publications

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“…In addition, IFN-g enhances maturation of CD8 + cytolytic T cells. Infiltration of mononuclear cells in the nerves in polyneuropathy associated with monoclonal gammopathy has been reported, mainly in patients with Waldenström's disease [38][39][40] but also in several studies in other cases of polyneuropathy associated with monoclonal gammopathy [41,42]. In a study of Bleasel et al [43], infiltrates in nerves of mainly macrophages, but also of CD4 + and CD8 + cells, were detected by immunohistochemical staining in patients with polyneuropathy associated with monoclonal gammopathy.…”

Section: Discussionmentioning

confidence: 95%

Th1-like responses to peptides from peripheral nerve myelin proteins in patients with polyneuropathy associated with monoclonal gammopathy

Ekerfelt¹,

Ernerudh²,

Vrethem³

1997

Clinical and Experimental Immunology

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SUMMARYPolyneuropathy associated with monoclonal gammopathy is usually regarded as an immune-mediated disorder with autoantibody activity against myelin glycoproteins. The pathogenic mechanisms are, however, not fully understood. Several reports have indicated an additional involvement of T cells. We investigated the occurrence of myelin-specific T cells as well as their functional characteristics. Cytokine responses generated after stimulation of peripheral blood mononuclear cells with selected peptides of myelin proteins P0 and P2 were investigated with an ELISPOT method. Three P0 peptides caused significantly elevated levels of interferon-gamma (IFN-g)-secreting cells in patients with polyneuropathy associated with monoclonal gammopathy (n ¼ 8) compared with controls (n ¼ 8), whereas none of the peptides caused elevated levels of IL-4-secreting cells. Patients with nonimmunological types of neuropathy (n ¼ 4) did not reveal any cytokine responses to myelin peptides. Our results indicate that a Th1-like response against myelin proteins occurs in polyneuropathy associated with monoclonal gammopathy.

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Section: Discussionmentioning

confidence: 95%

Th1-like responses to peptides from peripheral nerve myelin proteins in patients with polyneuropathy associated with monoclonal gammopathy

Ekerfelt¹,

Ernerudh²,

Vrethem³

1997

Clinical and Experimental Immunology

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“…Neurologic complications may occur in up to 25% of patients with WM 11) . The most frequent neurologic complication is sensorimotor polyneuropathy 11) . CNS manifestations are usually caused by serum hyperviscosity 8) .…”

Section: Discussionmentioning

confidence: 99%

“…Only extremely rare cases of Bing-Neel syndrome, involving direct CNS infiltration by malignant cells, have been reported 1,3,4,[9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

“…Some findings have been reported in presumed cases or histopathologicallydemonstrated cases 1,5) . Bing-Neel syndrome can be subdivided into diffuse and tumoral forms 11) . In the diffuse infiltrative form, the cerebral lymphoid infiltration predominates in the pons, medulla, periventricular white matter, and leptomeningeal spaces.…”

Section: Discussionmentioning

confidence: 99%

“…In the tumoral form, the lesion may be unifocal or multifocal, and is usually located in the deep subcortical hemispheric regions. Nervous system infiltrations appear as contrast-enhancement and/or thickening of meningeal sheaths on computerized tomography or MRI, and may involve the brain parenchyma and cauda equina 7,11) . In our case, MRI displayed edematous infiltrative lesions in the periventricular white matter, basal ganglia, thalamus, hypothalamus, midbrain, pons, cerebellar peduncle, and cerebellum.…”

Section: Discussionmentioning

confidence: 99%

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Brain Magnetic Resolution Imaging to Diagnose Bing-Neel Syndrome

Kim

Suh

Kim

et al. 2009

J Korean Neurosurg Soc

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J Korean Neurosurg Soc 46 : [588][589][590][591] 2009 Radiologic findings of Bing-Neel syndrome, which is an extremely uncommon complication resulting from malignant lymphocyte infiltration into the central nervous system (CNS) in patients with Waldenström's macroglobulinemia (WM), have been infrequently reported due to extreme rarity of the case. A 75-year-old man with WM presented at a neurology clinic with progressive gait and memory disturbances, and dysarthria of 2 months duration. Cerebrospinal fluid and serum protein electrophoresis and immunofixation electrophoresis showed IgM kappa-type monoclonal gammopathy. Brain magnetic resonance imaging revealed multifocal, hyperintense lesions on T2 weighted-images. Brain diffusionweighted imaging (DWI) demonstrated hyperintensities in cerebral and cerebellar lesions that appeared isointense on apparent diffusion coefficient maps, which were compatible with vasogenic edema. Although histologic analysis is a confirmative study to prove direct cell infiltration into the brain, brain MRI with DWI may be a good supportive study to diagnose Bing-Neel syndrome.

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Waldenström's Macroglobulinemia

Deuel¹

1983

Arch Intern Med

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Neurologic Aspects of Waldenström's Macroglobulinemia

Cited by 123 publications

References 19 publications

Th1-like responses to peptides from peripheral nerve myelin proteins in patients with polyneuropathy associated with monoclonal gammopathy

Th1-like responses to peptides from peripheral nerve myelin proteins in patients with polyneuropathy associated with monoclonal gammopathy

Brain Magnetic Resolution Imaging to Diagnose Bing-Neel Syndrome

Waldenström's Macroglobulinemia

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