Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors

Colin, Idesbald; Blondeau, Claude; Baude, Agnès

doi:10.1016/s0306-4522(02)00541-9

Cited by 30 publications

(28 citation statements)

References 60 publications

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“…Nuclear translocation of NK receptors has not been reported previously despite the extensive studies on the internalization and recycling of these receptors (Grady et al, 1995;Mantyh et al, 1995;McConalogue et al, 1998;Jenkinson et al, 2000;Colin et al, 2002;Sabino et al, 2002;Marvizon et al, 2003). This is not unexpected for the NK1-R because it does not contain a putative NLS (Takeda et al, 1991;Takahashi et al, 1992).…”

Section: Discussionmentioning

confidence: 93%

“…Internalization of NK1-R has been used extensively to study the role of SP in physiological responses (Sabino et al, 2002;Marvizon et al, 2003). Ligand-induced NK3-R internalization has also been demonstrated (Colin et al, 2002;Schmidlin et al, 2003), but to our knowledge, NK3-R internalization has not been used previously to identify the nature of the neurotransmitter involved in specific physiological responses. In the current studies, rapid internalization of the NK3-R occurred in SON after hydralazine-induced hypotension.…”

Section: Discussionmentioning

confidence: 99%

“…Nuclear localization was not observed after the SP injection (C2). physiological and pharmacological stimuli (Colin et al, 2002;Sabino et al, 2002). We used NK3-R internalization to assess the hypotheses that (1) SP acts as a ligand for NK3-Rs in SON and (2) NK3-Rs in SON are activated in response to hypotension.…”

Section: Effect Of Nk3-r Antagonistsmentioning

confidence: 99%

See 2 more Smart Citations

Role of Neurokinin 3 Receptors in Supraoptic Vasopressin and Oxytocin Neurons

Howe

Somponpun²,

Sladek³

2004

J. Neurosci.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Neurokinin 3 Receptors in Supraoptic Vasopressin and Oxytocin Neurons

Howe

Somponpun²,

Sladek³

2004

J. Neurosci.

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“…The DVC in rats is enriched with axon terminals containing NKA and NKB (Colin et al, 2002), and the activation of NK1 receptors in the NTS has been shown to increase the release of glutamate (Bailey et al, 2004), which, in turn can lead to the release of neurokinins (Colin et al, 2002). However, further studies are needed to clarify, whether the release of NKA and NKB is involved in the gastroprotective effect of SP.…”

Section: Discussionmentioning

confidence: 99%

Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats

Brancati

Zádori

Németh

et al. 2013

Brain Research Bulletin

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The aim of the present study was to analyze the potential role of substance P (SP) in gastric mucosal defense and to clarify the receptors and mechanisms, that may be involved in it. Gastric ulceration was induced by oral administration of acidified ethanol in male Wistar rats. Mucosal levels of calcitonin gene-related peptide (CGRP) and somatostatin were determined by radioimmunoassay. For analysis of gastric motor activity the rubber balloon method was used. We found that central (intracerebroventricular) injection of SP (9.3 -74 pmol) dosedependently inhibited the formation of ethanol-induced ulcers, while intravenously injected SP (0.37-7.4 nmol/kg) had no effect. The mucosal protective effect of SP was inhibited by pretreatment with neurokinin 1-, neurokinin 2-, neurokinin 3-and μ-opioid receptor antagonists, while δ-and κ-opioid receptor antagonists had no effect. Endomorphin-2 antiserum also antagonized the SP-induced mucosal protection. In the gastroprotective dose range SP failed to influence the gastric motor activity. Inhibition of muscarinic cholinergic receptors, or the synthesis of nitric oxide or prostaglandins significantly reduced the effect of SP. In addition, centrally injected SP reversed the ethanolinduced reduction of gastric mucosal CGRP content. It can be concluded, that SP may induce gastric mucosal protection initiated centrally. Its protective effect is likely to be mediated by endomorphin-2, and vagal nerve may convey the centrally initiated protection to the periphery, where both prostaglandins, nitric oxide and CGRP are involved in mediating this effect.

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“…Interestingly, other mechanisms leading to SP release from axon terminals within the NTS have been suggested; for instance, glutamate may contribute to NK release in the NTS by excitation of postsynaptic ionotropic glutamate receptors localized on NK-containing neurons (see Ref. 18 also for further references) The modulatory role of substance P within the caudal NTS may be relevant to central mechanisms involved in the regulation of the cough reflex, including central sensitization and plasticity phenomena induced by some pathophysiological conditions, such as gastroesophageal reflux and airway diseases (12,28,40,43,63).…”

Section: Discussionmentioning

confidence: 99%

Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit

Mutolo¹,

Bongianni²,

Cinelli³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

131

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We have previously shown that ionotropic glutamate receptors in the caudal portion of the nucleus tractus solitarii (NTS), especially in the commissural NTS, play a prominent role in the mediation of tracheobronchial cough and that substance P potentiates this reflex. This NTS region could be a site of action of some centrally acting antitussive agents and a component of a drug-sensitive gating mechanism of cough. To address these issues, we investigated changes in baseline respiratory activity and cough responses to tracheobronchial mechanical stimulation following microinjections (30 -50 nl) of centrally acting antitussive drugs into the caudal NTS of pentobarbitone-anesthetized, spontaneously breathing rabbits. [D-Ala 2 ,N-Me-Phe 4 ,Gly 5 -ol]-enkephalin (DAMGO) and baclofen decreased baseline respiratory frequency because of increases in the inspiratory time only at the higher concentration employed (5 mM and 1 mM, respectively). DAMGO (0.5 mM) and baclofen (0.1 mM) significantly decreased cough number, peak abdominal activity, peak tracheal pressure, and increased cough-related total cycle duration. At the higher concentrations, these agents suppressed the cough reflex. The effects of these two drugs were counteracted by specific antagonists (10 mM naloxone and 25 mM CGP-35348, respectively). The neurokinin-1 (NK1) receptor antagonist CP-99,994 (10 mM) abolished cough responses, whereas the NK2 receptor antagonist MEN 10376 (5 mM) had no effect. The results indicate that the caudal NTS is a site of action of some centrally acting drugs and a likely component of a neural system involved in cough regulation. A crucial role of substance P release in the mediation of reflex cough is also suggested.-opioid receptors; GABAB receptors; neurokinin receptors; control of breathing; airway defensive reflexes PREVIOUS STUDIES LED TO THE conclusion that some antitussive drugs act centrally since they inhibit cough when administered by intravertebral arterial or intracerebroventricular route in guinea pigs and cats (7,8). These drugs comprise the opioid receptor agonist codeine, the -opioid receptor agonist morphine, the neurokinin-1 (NK 1 ) receptor antagonist (ϩ)(2R,3R)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994), the NK 2 receptor antagonist {(ϩ)-N-methyl-[4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-di-dichlorophenyl) butyl]benzamide} (SR48968), and the GABA B receptor agonist baclofen. A prominent central antitussive effect has been proven for the selective -opioid receptor agonist [D-Ala 2 ,N-Me-Phe 4 ,Gly 5 -ol]-enkephalin (DAMGO) by using intracerebroventricular administration in the rat (30). However, the central responsive structures and the mechanism of action of these drugs remain to be investigated.It is widely agreed that tracheobronchial rapidly adapting receptors (RARs) are involved in cough mediation, while the role of bronchopulmonary C-fibers and A␦-nociceptive pulmonary afferent fibers in this reflex is controversial (see e.g., 36, 49, 62; for further references, also see Ref. 43). We have ...

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Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors

Cited by 30 publications

References 60 publications

Role of Neurokinin 3 Receptors in Supraoptic Vasopressin and Oxytocin Neurons

Role of Neurokinin 3 Receptors in Supraoptic Vasopressin and Oxytocin Neurons

Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats

Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit

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