Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication

Marklund, Niklas; Enblad, Per; Ronne-Engström, Elisabeth

doi:10.1007/s12028-007-0060-6

Cited by 3 publications

(1 citation statement)

References 21 publications

(24 reference statements)

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“…In the current study, valporoic acid overdose (VPA) overdose revealed electrolyte abnormalities that included hypernatremia and hypocalcemia. This is consistent with the result described by Marklund et al (2007). VPA toxicity causes hypernatremia since it is a sodium salt (Na+ present in the VPA preparation).…”

Section: Discussionsupporting

confidence: 93%

Study of Electrocardiographic Changes Associated with Acute Poisoning in Tanta Poison Center

Heshmat

Maklad

Elsheikh

et al. 2012

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Poisoning or intoxication is the occurrence of harmful effects resulting from exposure to a foreign substance. According to the Center for Disease Control, approximately 1 million of the 110 million annual emergency department (ED) visits are related to poisoning and other toxic effects. Electrocardiogram (ECG) is a noninvasive, relatively inexpensive diagnostic test that provides important information regarding not only the heart, but also non-cardiac events impacting the cardiac system. The aim of this study was to evaluate the electrocardiographic changes conducted on 282 cases of acute poisoning admitted to Tanta Poison Center, Faculty of Medicine, Tanta Emergency University Hospital during the period from the start of July-2009 to the end of June-2010. In order to fulfill this aim, each patient was subjected to history taking, complete physical examination, laboratory investigations and ECG analysis. This study found that poisons associated with ECG changes account for 58.5 % of patients included in this study. Furthermore, 36.17% of patients are mainly in the middle age group between 20 and 30 years. Organophosphorus compounds (34.4%) were responsible for most cases of intoxication of ECG changes. Sinus tachycardia (73.94%) was the commonest ECG change among them. Followed by prolonged QT corrected for heart rate (QTc) interval (21.82 %) and sinus bradycardia (11.51 %).

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Section: Discussionsupporting

confidence: 93%