Neuroimaging tests for clinical psychiatry: Are we there yet?

Leyton, Marco; Kennedy, Sidney H.

doi:10.1503/jpn.170109

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…More recently, it has been shown that the pattern of functional connectivity across an individual’s brain represents a unique neuronal ‘fingerprint’ that can be used to identify that individual from within a large group and remains stable across time and testing conditions. 99,100 Functional connectivity fingerprints appear to stabilize during adolescent development, 101 and there is evidence that both delayed stabilization and particular patterns of whole-brain connectivity are associated with certain cognitive-affective traits 102 and psychiatric disorders. 103 For example, in a large sample of over 1,100 patients with depression, Drysdale and colleagues recently showed that distinct patterns of functional connectivity across limbic and frontostriatal networks could be used to group patients with depression into four subtypes with different clinical-symptom profiles 104 – putative endophenotypes.…”

Section: Precision Psychiatry and Neurosciencementioning

confidence: 99%

Precision neuroradiology: mapping the nodes and networks that link genes to behaviour

Sugrue¹,

Desikan

2019

The British Journal of Radiology

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What is the future of neuroradiology in the era of precision medicine? As with any big change, this transformation in medicine presents both challenges and opportunities, and to flourish in this new environment we will have to adapt. It is difficult to predict exactly how neuroradiology will evolve in this shifting landscape, but there will be changes in both what we image and what we do. In terms of imaging, we will need to move beyond simply imaging brain anatomy and toward imaging function, both at the molecular and circuit level. In terms of what we do, we will need to move from the periphery of the clinical enterprise toward its center, with a new emphasis on integrating imaging with genetic and clinical data to form a comprehensive picture of the patient that can be used to direct further testing and care. The payoff is that these changes will align neuroradiology with the emerging field of precision psychiatry, which promises to replace symptom-based diagnosis and trial-and-error treatment of psychiatric disorders with diagnoses based on quantifiable genetic, imaging, physiologic, and behavioural criteria and therapies targeted to the particular pathophysiology of individual patients. Here we review some of the recent developments in behavioural genetics and neuroscience that are laying the foundation for precision psychiatry. By no means comprehensive, our goal is to introduce some of the perspectives and techniques that are likely to be relevant to the precision neuroradiologist of the future.

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Section: Precision Psychiatry and Neurosciencementioning

confidence: 99%

Precision neuroradiology: mapping the nodes and networks that link genes to behaviour

Sugrue¹,

Desikan

2019

The British Journal of Radiology

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“…While neurons related to the hypothalamic system, brain stem and medullary system present modest losses of neuron or volume [17,18]. Molecular studies suggest that ageing is a process related to apoptosis (ie, …”

Section: Differences Between the Young And Old Brainmentioning

confidence: 99%

The Role of Neuroimaging in the Ageing Brain

Ambrosi¹,

Junior²,

Ambrosi³

2017

JNSK

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It is of crucial importance to recognize the changes that occur in the brain ageing. Although neuroimaging studies are important tools used in the evaluation of changes in brain ageing mainly through the exclusion of comorbidities and neurodegenerative disorders, their role is still controversial. In this minireview, we discuss the main aspects of brain ageing, the differences between the young and old brain, the neuroimaging techniques and the use of neuroimaging to assess brain age. Differentiating the differences between normal structural and pathological ageing will provide a deeper understanding of the ageing process of the brain and will bring us new perspectives on biomarkers.

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Neuroimaging tests for clinical psychiatry: Are we there yet?

Cited by 2 publications

References 34 publications

Precision neuroradiology: mapping the nodes and networks that link genes to behaviour

Precision neuroradiology: mapping the nodes and networks that link genes to behaviour

The Role of Neuroimaging in the Ageing Brain

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