Neurohypophyseal hormones: novel actors of striated muscle development and homeostasis

Abstract

Since the 1980’s, novel functional roles of the neurohypophyseal hormones vasopressin and oxytocin have emerged. Several studies have investigated the effects of these two neurohormones on striated muscle tissues, both in vitro and in vivo. The effects of vasopressin on skeletal myogenic cells, developing muscle and muscle homeostasis have been documented. Oxytocin appears to have a greater influence on cardiomyocite differentiation and heart homeostasis. This review summarizes the studies on these novel roles of the two neurohypophyseal hormones, and open the possibility of new therapeutic approaches for diseases affecting striated muscle.

Microbial lysate upregulates host oxytocin

“…Interestingly, many of the published beneficial health effects of oxytocin overlap with recognized L. reuteri health-promoting attributes. Indeed, as with L. reuteri (Britton et al, 2014; Collins et al, 2016; Poutahidis et al, 2013a,b; Varian et al, 2016a,b, 2014; Zhang et al, 2015b), the exogenous administration of oxytocin has been shown to accelerate wound healing (Gavrilenko et al, 2003; Gouin et al, 2010; Vitalo et al, 2009), counteract obesity (Barengolts, 2016; Blevins and Baskin, 2015), suppress uncontrolled inflammation (Wang et al, 2015) and prevent muscle wasting (Costa et al, 2014; Elabd et al, 2014) and bone loss (Colaianni et al, 2014; Sun et al, 2016; Tamma et al, 2009). …”

Culture conditions influence satellite cell activation and survival of single myofibers

“…The direct comparison of very different culture conditions allows, for the first time, to choose the most appropriate medium and surface coating to favour SC quiescence vs. their activation, the maintenance of intact fibers vs the migration of SC, the proliferation vs. the differentiation of SC and last, the use of serum-free medium to investigate the effect of specific factors. 25 , 26 , 31 …”

Exercise against tumor- and chemotherapy-induced muscle wasting

“…The most relevant research on chemotherapy-induced muscle wasting are summarized in a recent review published in European Journal of Translation Myology [52]. The European Journal of Translation Myology has published many papers related to muscle wasting linked to mobility disorders [53][54][55][56][57][58][59], to muscle atrophy in sarcopenia and disease states [60][61][62], and to physical exercise [63,64]. Originally devoted to biology, physiology, diagnostic, and to the rehabilitation of skeletal muscle tissue, the journal is now moving forward to cover additional fields in myology, thus taking on a broader medical and clinical interest.…”