Neurogenesis in an adult insect brain and its hormonal control

Cayre, Myriam; Strambi, Colette; Strambi, Alain

doi:10.1038/368057a0

Cited by 158 publications

(127 citation statements)

References 29 publications

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“…The sensitivity changes of pheromoneresponding AL interneurons with the hormonal status indicate that hormone-mediated neuronal plasticity occurs in the adult moth brain. Age-dependent plasticity in adult brain structure was previously shown in social insects (19,20), and an influence of JH on neurogenesis in the brain was found in crickets (3). JH also was shown in crickets to act on the sensitivity of auditory interneurons controlling phonotaxis (21).…”

Section: Discussionmentioning

confidence: 92%

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Effect of juvenile hormone on the central nervous processing of sex pheromone in an insect

Anton

Gadenne

1999

Proc. Natl. Acad. Sci. U.S.A.

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Behavioral sex pheromone responsiveness in the male moth Agrotis ipsilon was previously shown to be controlled by juvenile hormone (JH). However, this morphogenetic hormone did not change the sensitivity of antennae to sex pheromones. To analyze the possible involvement of JH in the central integration of the female-produced sex pheromone, we investigated the pheromone response of olfactory antennal lobe (AL) interneurons in male A. ipsilon as a function of age and JH status by using intracellular recordings. When the antennae were stimulated with the sex pheromone blend, the sensitivity of olfactory AL neurons increased with age, as does the JH-dependent behavioral and physiological development of A. ipsilon males. Furthermore, males surgically deprived of JH showed a significant decrease in the sensitivity of the AL neurons. JH injection in operated or in young males restored or induced, respectively, a high sensitivity of the AL neurons. JH seems likely to be involved in the plasticity of the adult insect brain by modulating the central nervous processing of olfactory information, thus allowing mate recognition and reproduction at the optimal time.

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Section: Discussionmentioning

confidence: 92%

“…JH was shown to be involved in central nervous regulation of phonotaxis (2) and in neurogenesis in potential oviposition steering brain areas in the house cricket (3). JH also plays a role in the honeybee related to behavioral maturation and brain structure (see ref.…”

mentioning

confidence: 99%

Effect of juvenile hormone on the central nervous processing of sex pheromone in an insect

Anton

Gadenne

1999

Proc. Natl. Acad. Sci. U.S.A.

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“…Neurogenesis in the brains of insects and crustaceans is influenced by hormones and polyamines (Cayre et al, 1994;Cayre et al, 2001), serotonin levels , sensory inputs (Hansen and Schmidt, 2001;Scotto-Lomassese et al, 2002), environmental richness (Sandeman and Sandeman, 2000;Hansen and Schmidt, 2004), circadian rhythm (Goergen et al, 2002) and season (Hansen and Schmidt, 2004).…”

Section: Introductionmentioning

confidence: 99%

Social domination increases neuronal survival in the brain of juvenile crayfishProcambarus clarkii

Song

Johnstone

Schmidt

et al. 2007

Journal of Experimental Biology

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SUMMARY Olfactory cues are among the sensory inputs that crayfish use in establishing dominance hierarchies. Throughout their lives, new neurons are continuously added into brain cell clusters 9 and 10, which contain somata of olfactory local and projection interneurons, respectively. Using markers for DNA synthesis (bromodeoxyuridine) and mitosis (phospho-histone-3), we tested juvenile crayfish (Procambarus clarkii) to examine effects of pairwise social experience on proliferation and survival of cells in these brain regions. Proliferating and mitotic cells appeared within restricted neurogenic areas in both clusters and in `tails' extending from them. These tails, embedded in tubulin-positive strands, are linked by a patch of cells. Neither cell proliferation nor mitotic activity was affected by social dominance. Cell survival of neuronal precursors was affected by dominance:compared to dominants, subordinates had fewer newborn cells surviving in cluster 9 after 14 days of social experience. Social experience also affected body growth rate, but the effect of social experience on neurogenesis remained when differences in body growth rate were statistically controlled. We conclude that social domination enhances survival of new olfactory interneuronal precursors compared to social subordination but not compared to social isolation.

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“…So far, this concept has mainly been explored in vertebrates because other aging models, such as adult insects, have been regarded as largely postmitotic (Finch, 1990). But cell proliferation has been observed in adult insect tissues ( [Cayre et al, 1994] and [Corley and Lavine, 2006]) and the insect intestine in particular is characterized by high levels of regenerative stem cell proliferation (Ohlstein and Spradling, 2006). Furthermore, an age-related decline in digestive efficiency in honeybees has been reported (Crailsheim et al, 1992).…”

mentioning

confidence: 99%

Age, caste, and behavior determine the replicative activity of intestinal stem cells in honeybees (Apis mellifera L.)

Ward

Coleman

Clinnin

et al. 2008

Experimental Gerontology

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Abstract:Honeybees (Apis mellifera L.) display a pronounced natural aging plasticity. The differences in aging rates between the alternative phenotypes and behavioral classes could reflect differences in protection against damage or in the ability to repair vulnerable tissues. As in other animals, including humans, the gut is continually exposed to environmental insults and harbors a large population of replicating stem cells that maintain the intestinal epithelium. Through studies of the major internal organs using incorporation and immunodetection of the mitotic marker bromodeoxyuridine, the intestine was determined to be the main site of tissue renewal in adult honeybees. Proliferative activity of the intestinal stem cells was compared among queens, workers, and males of different ages. Simultaneous attempts to assess intestinal cell loss via apoptosis yielded inconclusive results. The relationship between intestinal cell proliferation and worker life-history was evaluated in greater depth by studying diutinus winter workers, reproductive workers, and by decoupling worker behavioral status from chronological age in a single-cohort colony. Intestinal cell proliferation was abundant in all groups and showed an agerelated decline in workers, queens, and males. At young ages, workers exhibited relatively more intestinal cell proliferation than did queens and queens more than drones, but the caste and sex differences decreased with age. Cell proliferation did not decrease beyond 6 weeks of age in older queens and in diutinus workers. Ovary activation did not correlate with the amount of intestinal stem cell proliferation in workers, although the queenless hive condition was associated with lower overall counts. In the single-cohort colony, nurse bees exhibited more cell proliferation than foragers, regardless of age. The overall results do not support our hypothesis that longer-lived phenotypes exhibit increased somatic repair in the form of higher replicative activity of intestinal stem cells. Instead, the observed proliferation patterns reflect differential demands for digestive activity in the different groups, which result in different requirements for replacement of lost intestinal cells. The maintenance of proliferative capacity for over 1 year suggests that queen intestinal stem cells have a relatively high replicative potential, but further studies are needed to relate honeybee lifespan differences to cellular aging.

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Neurogenesis in an adult insect brain and its hormonal control

Cited by 158 publications

References 29 publications

Effect of juvenile hormone on the central nervous processing of sex pheromone in an insect

Effect of juvenile hormone on the central nervous processing of sex pheromone in an insect

Social domination increases neuronal survival in the brain of juvenile crayfishProcambarus clarkii

Age, caste, and behavior determine the replicative activity of intestinal stem cells in honeybees (Apis mellifera L.)

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