Neurofilaments and traumatic brain injury

Kobek, Mariusz; Skowronek, Rafał; Jankowski, Zbigniew; Pałasz, Artur

doi:10.5114/amsik.2014.50531

Cited by 6 publications

(3 citation statements)

References 28 publications

(77 reference statements)

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“…the time that has lapsed since the trauma [2,13,17]. However, laboratory practice has shown that these methods are not accurate enough and therefore pose a danger of diagnostic errors.…”

Section: Introductionmentioning

confidence: 99%

Time-related morphometric studies of neurofilaments in brain contusions

Kobek¹,

Jankowski²,

Szala³

et al. 2016

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“…the time that has lapsed since the trauma [2,13,17]. However, laboratory practice has shown that these methods are not accurate enough and therefore pose a danger of diagnostic errors.…”

Section: Introductionmentioning

confidence: 99%

Time-related morphometric studies of neurofilaments in brain contusions

Kobek¹,

Jankowski²,

Szala³

et al. 2016

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“…Immunohistochemical markers of structural degeneration are of value. For example, accumulation of neurofilament (33)(34)(35)(36) and proteolytic fragments of alpha spectrin, one of the proteins at the interface between the axoskeleton and the membrane (37), are reliable indicators of focal damage. Many proteins that undergo anterograde transport to the synapse accumulate can be detected by immunohistochemistry at the site of damage (38,39).…”

Section: Axon Changes Following Traumatic and Hypoxic-ischemic Brain Injurymentioning

confidence: 99%

Histology of Brain Trauma and Hypoxia-Ischemia

Rahaman¹,

Bigio²

2018

Academic Forensic Pathology

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Forensic pathologists encounter hypoxic-ischemic (HI) brain damage or traumatic brain injuries (TBI) on an almost daily basis. Evaluation of the findings guides decisions regarding cause and manner of death. When there are gross findings of brain trauma, the cause of death is often obvious. However, microscopic evaluation should be used to augment the macroscopic diagnoses. Histology can be used to seek evidence for TBI in the absence of gross findings, e.g., in the context of reported or suspected TBI. Estimating the survival interval after an insult is often of medicolegal interest; this requires targeted tissue sampling and careful histologic evaluation. Retained tissue blocks serve as forensic evidence and also provide invaluable teaching and research material. In certain contexts, histology can be used to demonstrate nontraumatic causes of seemingly traumatic lesions. Macroscopic and histologic findings of brain trauma can be confounded by concomitant HI brain injury when an individual survives temporarily after TBI. Here we review the histologic approaches for evaluating TBI, hemorrhage, and HI brain injury. Amyloid precursor protein (APP) immunohistochemistry is helpful for identifying damaged axons, but patterns of damage cannot unambiguously distinguish TBI from HI. The evolution of hemorrhagic lesions will be discussed in detail; however, timing of any lesion is at best approximate. It is important to recognize artifactual changes (e.g., dark neurons) that can resemble HI damage. Despite the shortcomings, histology is a critical adjunct to the gross examination of brains.

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“…Damaged nervous tissue releases various substances that may have potential as markers of the time elapsed since an injury [78]. Inflammation of the CNS after trauma is similar to that of damaged skin and skeletal muscle, whereas the local reaction (including migration of glial cells) is specific to the CNS [5].…”

Section: Brain Injurymentioning

confidence: 99%

Vitality and wound-age estimation in forensic pathology: review and future prospects

Bai

et al. 2018

Forensic Sciences Research

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Determining the age of a wound is challenging in forensic pathology, but it can contribute to the reconstruction of crime scenes and lead to arrest of suspects. Forensic scholars have tended to focus on evaluating wound vitality and determining the time elapsed since the wound was sustained. Recent progress in forensic techniques, particularly high-throughput analyses, has enabled evaluation of materials at the cellular and molecular levels, as well as simultaneous assessment of multiple markers. This paper provides an update on wound-age estimation in forensic pathology, summarizes the recent literature, and considers useful additional information provided by each marker. Finally, the future prospects for estimating wound age in forensic practise are discussed with the hope of providing something useful for further study.

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Neurofilaments and traumatic brain injury

Cited by 6 publications

References 28 publications

Time-related morphometric studies of neurofilaments in brain contusions

Time-related morphometric studies of neurofilaments in brain contusions

Histology of Brain Trauma and Hypoxia-Ischemia

Vitality and wound-age estimation in forensic pathology: review and future prospects

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