Neurofibroma of the stomach without Recklinghausen’s disease: a

Abstract

Neurofibromas of the stomach can occur in the course of Recklinghausen's disease. Sporadic gastric neurofibroma appears rarely. This tumour may look like an ulcer and can be a cause of abdominal pain, nausea, and bleeding from the gastrointestinal tract. We reported a 61-year-old women complaining of stomachache for several months. Gastroscopy revealed a tumour with ulceration in the prepyloric part of the stomach. Helicobacter pylori infection was also present. Helicobacter pylori eradication and prolonged treatment of proton pump inhibitors did not decrease the ailments or the size of the tumour. It was not possible to determine the nature and origin of the tumour by carrying out examinations such as endoscopic ultrasound and computed tomography of the abdomen. Only after surgery and histopathological examination with immunohistochemistry was this tumour identified as a neurofibroma. In order to differentiate the tumour the following immunohistochemical examinations were carried out: CD34 (slightly +), CD117 (–), S-100 (+), desmin (–), NSE (+), GFAP (–), SMA (–), bc12 (–), CD99 (–), ALK1 (–), and MiB (1–1.5%). In such cases excision of the tumour is the preferred treatment.

Safety and Efficacy of Endoscopic Treatment of Solitary Gastric Neurofibroma

“…NSE is an isoenzyme specifically secreted by central neurons and neuroendocrine cells, which participates in the metabolic processes of nerve cells and maintains the normal physiological function of the nervous system. NSE is positive in solitary GN as reported by Madro et al 3 Of the patients, 45.5% were positive for NSE in our study, which further confirmed that the lesion was neurogenic. Positive NSE, S-100 protein, cannot predict prognosis.…”

“…Solitary neurofibroma is a local single tumor without other manifestations of NF, often presenting different clinical manifestations because of its occurrence in different locations. 3 To date, solitary neurofibroma has been reported in the oral cavity, 4 mandible, 5 parotid gland, 6 penis, 7 spermatic cord, 8 infratemporal fossa, 9 abdominal wall, 10 gallbladder, 11 bile duct, 12 esophagus, 13 colon, 14 etc. However, the studies on solitary gastric neurofibroma (GN) consist only individual case reports, with little data and little usable information.…”

“…Its preoperative diagnosis is difficult, and it requires intraoperative or postoperative pathological examination for an accurate diagnosis. 3 , 8 Surgery has been the preferred treatment for GN in the past. With the rapid development of endoscopic diagnosis and treatment technology, endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), endoscopic full-thickness resection (EFTR), and submucosal tunneling endoscopic resection (STER) are increasingly being used for removing gastrointestinal submucosal tumors.…”

Gastric Schwannoma: A Case Report and Review of the Literature for Gastric Submucosal Masses Distinction

“…Gastrointestinal neurogenics derive from different components of nerve fibers, mostly autonomic components of Auerbach's plexus [ 4 ]. They consist 5% of nonepithelial gastric tumors and are mostly benign with 10% malignant transformation risk [ 5 , 6 ]. Schwannoma, neurofibroma, and granular cell tumors are their subtypes.…”

Submucosal tumors of the stomach: clinic, diagnosis, treatment (literature review and own clinical observations)

“…Шванома шлунка була впер-ше описана на початку ХХ століття H. Verocay. Шваноми (невриноми, неврилемома) шлунка зустрічаються дуже рідко, здебільшого є проявом хвороби Реклінхаузена [13] та вкрай рідко -спорадичною хворобою. За даними різних авторів, вони становлять близько 0,2% всіх пухлин шлунка і близько 4% доброякісних пухлин шлунка [3].…”