Neuroendocrine Small Cell Carcinoma of the Cervix Associated with Endocervical Adenocarcinoma

Alphandery, Claudia; Dagrada, Gian Paolo; Frattini, Milo; Perrone, Federica; Pilotti, Silvana

doi:10.1159/000325803

Cited by 18 publications

(20 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cervical SCNEC is reliably associated with high‐risk HPV, especially HPV‐18. In one case of adenocarcinoma admixed with SCNEC, HPV‐18 DNA was detected in both components . Moreover, p16, which has been recognized as a putative surrogate marker of high‐risk HPV, is expressed in the majority of cervical SCNEC .…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

“…In one case of adenocarcinoma admixed with SCNEC, HPV-18 DNA was detected in both components. 7 Moreover, p16, which has been recognized as a putative surrogate marker of high-risk HPV, is expressed in the majority of cervical SCNEC. 4,6,7 Although HPV analysis was not performed in the present case, p16 was diffusely expressed in both AIS and SCNEC components.…”

Section: Introductionmentioning

confidence: 99%

“…5 Only 2 cytological reports on adenocarcinoma admixed with SCNEC have been reported in the English language literature. 6,7 In this report, we describe the first cytological case of cervical adenocarcinoma in situ (AIS) admixed with SCNEC and discuss cytological differential diagnostic considerations.A 65-year-old postmenopausal Japanese female (gravida 3 para 2), who had past history of tuberculous pleuritis, leiomyoma of the uterus, and asthma, presented with abnormal genital bleeding at our hospital.Cervical and endometrial cytological examinations and endometrial biopsy were performed. Endometrial biopsy contained atrophic endometrial tissue, but no neoplastic changes were noted.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features

Nishiumi¹,

Nishimura²,

Kashu³

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

Primary cervical small cell neuroendocrine carcinoma (SCNEC) is a rare and aggressive tumor. Herein, we describe the first cytological case of adenocarcinoma in situ (AIS) admixed with SCNEC. A 65-year-old postmenopausal Japanese female presented with abnormal genital bleeding. The Papanicolaou smear of the cervix demonstrated the presence of 2 distinct neoplastic components in an inflammatory background. One component consisted of aggregates of small round cells with a high nuclear/cytoplasmic ratio and round to oval nuclei with powdery chromatin, and inconspicuous nucleoli. Nuclear molding was characteristic. The other component consisted of irregular overlapping clusters of tall columnar cells with large round to oval nuclei containing coarse chromatin, and relatively rich cytoplasm. Accordingly, AIS admixed with SCNEC was suspected. Although the cytological features of cervical SCNEC are characteristic, the cytodiagnosis of this type of tumor may be difficult because of the rarity of the tumor. The presence of non-neuroendocrine tumor components in cervical SCNEC is not unusual, therefore careful observation is needed not to miss SCNEC components in the diagnosis of squamous cell carcinoma and/or adenocarcinoma in cervical cytological specimens.

show abstract

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features

Nishiumi¹,

Nishimura²,

Kashu³

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…At present, circa 30 cases of SNEC of cervix have been published. [1][2][3][4][5][6][7][8][9][10][11][12] SNEC of endometrium is also extremely rare. [13][14][15][16] However, there have been no studies on the status of KIT, platelet-derived growth factor receptor-α (PDGFRA), bcl-2 in these SNEC cases of female genital organs, except for one case of SNEC of endometrium, [17] which showed expressions of KIT and PDGFRA but no mutations in these genes.…”

Section: Introductionmentioning

confidence: 99%

Small cell neuroendocrine carcinoma of uterine cervix with expressions of KIT, PDGFRA and bcl-2 and with long survival

Terada

2016

CRCP

View full text Add to dashboard Cite

Primary small cell neuroendocrine carcinoma (SNEC) of uterine cervix is very rare; about 30 cases have been reported in literature. However, there have been no studies of KIT, PDGFRA, and bcl-2 in SNET of cervix. A 91-year-old woman presented vaginal bleeding which subsided by hemostatic drugs and balloon catheterization. Colposcopy showed a small tumor (6 mm) cervix and biopsy showed necrotic tissue and small atypical cells. They showed epithelioid features, small size, increased nucleo-cytoplasmic ratio, hyperchomatic nuclei, molded nuclei, scant cytoplasm, and absent nucleoli, thus fulfilling the criteria of SNEC of WHO. Immunohistochemically, tumor cells were positive for cytokeratin (CK) CAM5.2, CK AE1/3, CK7, CK8, CK18, CK19, NSE, synaptophysin, NCAM, KIT, PDGFRA, bcl-2, p53, and Ki-67 (labeling index = 100%). The tumor cells were negative for CK5, CK6, CK34BE12, CK14, CK20, EMA, chromogranin, CD45, CD138, CD20, CD3, CD99 (MIC-2), vimentin, S100 protein, α-smooth muscle actin, desmin, and myoglobin. Since neuroendocrine antigens (NSE, NCAM, synaptophysin, KIT and PDGFRA) were positive, a diagnosis of primary SNEC of cervix was made. Post-biopsy whole body studies revealed no other tumors. The patient rejected medical, surgical interventions because of very old age. She was followed-up, a mass of 5 cm was found in pelvic cavity. The patient is now alive 8 years after the diagnosis. The present case is the first of primary SNEC of cervix demonstrating positive KIT, PDGFRA, and bcl-2 proteins in a very old woman. The tumor was positive for many stem cells antigens, suggesting that the SNEC is a stem cell malignancy.

show abstract

Small cell carcinoma of the cervix in liquid‐based Pap test: Utilization of split‐sample immunocytochemical and molecular analysis

Giorgadze

Kanhere

Pang

et al. 2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

Small cell (neuroendocrine) carcinoma of the uterine cervix (SMCC) is a rare, highly aggressive malignant neoplasm. Both conventional and liquid-based cytology (LBC) cervical smears have low sensitivity in diagnosing SMCC, requiring immunocytochemical (ICH) confirmation. We present the first series of SMCC primarily diagnosed in cytology specimens, and ICH studies performed on the residual LBC specimens with subsequent confirmation of the diagnosis on surgical pathology specimens. Immunocytochemical stains for keratin, p16INK4, and neuroendocrine markers (synaptophysin, chromogranin, CD56) were performed on additional ThinPrep slides. HPV test used chromogenic in situ hybridization high risk HPV DNA probe. The Pap smears in all three specimens were highly cellular with a mixture of squamous cells and numerous well-preserved single or small cohesive clusters of malignant epithelial cells. Tumor cells were small, monomorphic with minimal cytoplasm and high nuclear/cytoplasmic ratio. There was significant nuclear overlap, but no nuclear molding, or smudging of nuclear chromatin. The chromatin pattern was stippled. A background tumor diathesis was prominent. Atypical squamous cells of undetermined significance (ASCUS) were noted in one case, and markedly abnormal squamous cells were seen in another case. The main cytology differential diagnoses included high-grade squamous intraepithelial lesion and an endometrial adenocarcinoma. Immunocytochemical positivity for the neuroendocrine markers supported the diagnoses of SMCC in all three cases. The morphologic features of the concurrent surgical pathology specimens were typical of SMCC. The tissue diagnoses were also confirmed by immunohistochemistry. Our study allows us to conclude that SMCC can be primarily diagnosed in LBC specimens using a panel of immunocytochemical stains.

show abstract

Neuroendocrine Small Cell Carcinoma of the Cervix Associated with Endocervical Adenocarcinoma

Cited by 18 publications

References 8 publications

Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features

Adenocarcinoma in situ admixed with small cell neuroendocrine carcinoma of the cervix: A case report with cytological features

Small cell neuroendocrine carcinoma of uterine cervix with expressions of KIT, PDGFRA and bcl-2 and with long survival

Small cell carcinoma of the cervix in liquid‐based Pap test: Utilization of split‐sample immunocytochemical and molecular analysis

Contact Info

Product

Resources

About