PMP arising from urachus comes from neoplastic cells with development of intestinal-type mucinous neoplasm. It shares a similar pathophysiology as PMP from appendix. CRS including total urethrectomy, partial cystectomy, and peritonectomy plus HIPEC can be considered as a new option of treatment for PMP originating from urachus.
We recently experienced an 87-yr-old man with gastric yolk sac tumor. Preoperative diagnosis was poorly differentiated adenocarcinoma in the cardia of stomach without apparent metastasis. A total gastrectomy was performed. The precise histological examination after surgery revealed the tumor was composed of pure gastric yolk sac tumor without adenocarcinomatous components. The surgical margin and the resected lymph nodes were histologically negative for the tumor and a curative resection was performed. Five months after the operation, enlargement of the intraabdominal lymph nodes occurred with elevation of serum alpha fetoprotein (AFP), and the patient died 2 mo later. Gastric yolk sac tumors are very rare, and only six cases of gastric yolk sac tumors have been previously reported in the literature. Five out of six cases are accompanied by components of adenocarcinoma, and our present case is the second report of pure gastric yolk sac tumor to the best of our knowledge.
The relationship of immunohistochemical indices of proliferating cell nuclear antigen (PCNA) and Ki-67 to local control and survival rates for patients with oesophageal squamous cell carcinomas treated by definitive radiotherapy (RT) was investigated. Biopsy materials before RT were obtained from 65 patients with oesophageal cancer. The median PCNA labelling index (LI) and the median Ki-67 LI were 52% and 45% respectively. The PCNA LI was independent of known prognostic factors on local control for oesophageal cancer, although Ki-67 LI correlated with several prognostic factors. In the univariate analysis, patients with the PCNA LI of < 52% or the Ki-67 LI of < 45% showed significantly higher local recurrence rates than those with higher LIs (both P < 0.05). This difference in local control rate according to LIs was prominent for the patients treated with conventional fractionation. In the multivariate analysis, T-stage ( P = 0.0056) and PCNA LI ( P = 0.0332) were significant factors for local control in the final model using a stepwise regression procedure. In conclusion, PCNA LI and Ki-67 LI were significantly correlated with local control probabilities in oesophageal squamous cell carcinomas treated by definitive RT. © 1999 Cancer Research Campaign
Abstract. Fatty tissue is not usually present within the thyroid gland. Only a few fat-containing thyroid lesions have been reported to date, and thyrolipoma is the most common fat-containing lesion of the thyroid gland. Thyrolipomatosis is a condition characterized by diffuse mature adipose cell infiltration of the normal thyroid gland. In this report, we describe what is, to the best of our knowledge, the 12th documented case of thyrolipomatosis, and review the fat-containing lesions of the thyroid gland. A 68-year-old Japanese woman presented with a neck mass that had first been noticed ~7 years earlier.A computed tomography scan revealed diffuse thyroid gland enlargement and total thyroidectomy was performed. The histopathological examination revealed that mature fatty tissue was diffusely distributed throughout the thyroid gland, as well as among the hyperplastic follicles. Capsular formation or amyloid deposition were not observed. Nuclear grooves or intranuclear cytoplasmic inclusions were not observed. Accordingly, thyrolipomatosis was diagnosed. Albeit rare, various neoplastic and non-neoplastic thyroid lesions may contain mature fatty tissue. Therefore, thyrolipomatosis must be included in the differential diagnostic consideration of fat-containing lesions of the thyroid gland. IntroductionAlthough there is usually no mature fatty tissue within the thyroid gland, fat-containing thyroid lesions have been reported (1). Fat-containing thyroid lesions may be classified into two groups, namely neoplastic and non-neoplastic lesions. Thyrolipoma, also referred to as lipoadenoma, is the most common fat-containing lesion of the thyroid gland; it is considered to be a variant of follicular adenoma and is characterized by the presence of mature adipose cells interspersed throughout the follicular adenoma (2). Moreover, a few cases of papillary carcinoma and follicular carcinoma with adipose cells have been reported (1). Non-neoplastic fat-containing thyroid lesions include amyloid goiter and Hashimoto thyroiditis (1,3).Albeit extremely rare, diffuse mature adipose cell infiltration of the normal thyroid gland has been previously reported, referred to as thyrolipomatosis or diffuse lipomatosis of the thyroid gland (2). To the best of our knowledge, only 11 cases have been documented in the literature to date (2,4-8). We herein describe an additional case of thyrolipomatosis and review the fat-containing thyroid lesions. Case reportA 68-year-old Japanese woman with a past history of diabetes mellitus and angina pectoris presented at the Kusatsu General Hospital in August 2016 with a neck mass that had been noticed ~7 years earlier. A computed tomography scan revealed diffuse thyroid gland enlargement, compressing the trachea, with multiple calcifications in the bilateral lobes. The serum thyroid-stimulating hormone and free thyroxine (FT4) levels were within the normal range (0.63 µIU/ml, range 0.4-4.0 µIU/ml; and 1.01 ng/dl, range 0.8-1.7 ng/dl, respectively), but the free triiodothyronine (FT3) level was mildly d...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.