Neuroendocrine neoplasms of the larynx

Overholt, S. Mark; Donovan, Donald T.; Schwartz, Mary R.; Laucirica, Rodolfo; Green, Linda K.; Alford, Bobby R.

doi:10.1288/00005537-199508000-00004

Cited by 44 publications

(46 citation statements)

References 15 publications

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“…The cited authors suggested that p53 mutation may be involved in the pathogenesis of atypical carcinoids. 31,34–36 Our present patient is also p53-positive.…”

Section: Discussionsupporting

confidence: 59%

“…McCluggage et al (1997) 35 also reported that 3 atypical laryngeal carcinoid patients were p53-positive. Overholt et al (1995) 36 found that 6 of 8 patients with laryngeal neuroendocrine neoplasms (including 2 atypical carcinoids) were p53-positive. The cited authors suggested that p53 mutation may be involved in the pathogenesis of atypical carcinoids.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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The incidence of cutaneous and subcutaneous metastases from atypical laryngeal carcinoids is approximately 20%. However, the pathogenesis and natural history of, and prognostic factors for, the condition remain poorly understood. We reported a 54-year-old female presented with cutaneous and subcutaneous metastases from atypical laryngeal carcinoid. Laryngoscopy revealed a 0.5 × 1.5-cm reddish mass on the laryngeal surface of the epiglottis. Under general anesthesia, a biopsy sample was obtained via suspension laryngoscopy. Routine pathology revealed atypical laryngeal carcinoid. Immunohistochemical staining of the sections of primary tumor was positive for cytokeratin, chromogranin A, synaptophysin, hypoxia-inducible factor-1α, P53, and CD56. GLUT-1, p-Akt, and PI3K were negative. The Ki-67 index was 15%. Supraglottic laryngectomy and selective right-neck dissection were performed. After 6 months, the patient complained of pain in the right wall of the chest; multiple cutaneous and subcutaneous nodules were evident at that site and in the abdomen. An abdominal nodule was biopsied and pathology revealed that the atypical metastatic carcinoid had metastasized to both cutaneous and subcutaneous areas of the abdomen. Chemotherapy was then prescribed. Currently, the intrathecal drug delivery system remains in place. No local recurrence has been detected. Furthermore, we systematically reviewed clinical manifestations of the disease, pathogenesis, prognostic factors, and treatment. The metastasis rate (cutaneous and subcutaneous) was approximately 12.2%. Thirty patients (62.5%) with cutaneous and subcutaneous metastases exhibited contemporaneous lymph node invasion. The 3-, 5-, and 10-year survival rates were 44.0%, 22.0%, and 13.0%, respectively.The prognosis of patients with atypical laryngeal carcinoids was poor. Relevant prognostic factors included the level of p53, human papilloma virus status, certain hypoxic markers, and distant metastasis. No optimal treatment for such metastases has yet been defined.

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“…The cited authors suggested that p53 mutation may be involved in the pathogenesis of atypical carcinoids. 31,34–36 Our present patient is also p53-positive.…”

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Wang¹,

Jia²,

Zhou³

et al. 2016

Medicine

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“…Atypical carcinoids are locally invasive tumors, although metastases to distant sites and organs have been described [3,7]. The small cell carcinoma is an extremely aggressive malignant tumor that has a biological behavior identical to the small cell carcinoma of the lung [2,9,10]. In general, the paraganglioma is mostly a benign lesion, but despite its histological appearance and biological behavior metastases have been reported [11].…”

Section: Introductionmentioning

confidence: 99%

Unusual features of metastatic atypical carcinoid of the larynx

Alujević

Jurić

Šeparović

et al. 1998

European Archives of Oto-Rhino-Laryngology

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This report describes a case of atypical carcinoid of the larynx with metastatic tumor to cervical lymph nodes showing features similar to paraganglioma. Immunohistochemically, both the primary and metastatic tumor were positive for epithelial membrane antigen, cytokeratin, neuron-specific enolase, chromogranin, synaptophysin, calcitonin and carcinoembryonic antigen. The sustentacular cells in pseudo-cell ball ("Zellballen") formations were shown by a positive S-100 marker. Electron microscopic analysis revealed numerous neuroendocrine granules measuring 150-250 nm in diameter. Clinical features, histological appearance, histochemical, immunohistochemical and ultrastructural findings, as well as differential diagnosis are discussed.

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“…An attempt to control the disease with chemotherapy was unsuccessful, and the patient died after 26 months. 65 The fourth case was in a 64-year-old man with an atypical carcinoid tumor of the larynx involving the surface of the epiglottis with cervical metastases. The patient had carcinoid syndrome (J.…”

mentioning

confidence: 99%

Paraneoplastic Syndromes in Patients with Cancer of the Larynx and Hypopharynx

Ferlito

Rinaldo²

2007

Ann Otol Rhinol Laryngol

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Paraneoplastic syndromes may be the first sign of a malignancy. They are systemic, nonmetastatic manifestations associated with a variety of malignant neoplasms and occurring in a minority of cancer patients. These associations of symptoms and signs are not directly related to the site or local manifestations of a malignant tumor or its metastases, but their recognition may facilitate the detection of malignancies or recurrences. Paraneoplastic syndromes are categorized into 6 types: dermatologic or cutaneous, endocrine, hematologic, neurologic, osteoarticular or rheumatologic, and ocular. Different oncotypes have rarely been associated with paraneoplastic syndromes in patients with cancer of the larynx and hypopharynx. The world literature has been reviewed.

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Neuroendocrine neoplasms of the larynx

Cited by 44 publications

References 15 publications

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Cutaneous and Subcutaneous Metastases From Atypical Laryngeal Carcinoids

Unusual features of metastatic atypical carcinoid of the larynx

Paraneoplastic Syndromes in Patients with Cancer of the Larynx and Hypopharynx

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