Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome

Gogna, Shekhar; Samson, David J; Gachabayov, Mahir; Rojas, Aram; Felsenreich, Daniel Moritz; Koo, Donna C.; Gu, Katie; Quintero, Luis Alberto Zarco; Miller, Kendall Ryan; Azim, Asad; Dong, Xiang Da

doi:10.1007/s00423-021-02256-z

Cited by 7 publications

(10 citation statements)

References 32 publications

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“…Zhou et al 30 retrospectively analyzed 446 patients with biliary NEN from the SEER database and found that young patients and patients with NET or smaller tumor size had a significantly better prognosis. Another SEER database study also revealed that age, tumor stage, extension, and grade were associated with the outcomes 28 . Adjuvant therapy has also been associated with improved OS rates 9 .…”

Section: Discussionmentioning

confidence: 97%

“…Ayabe et al 8 analyzed 300 patients from a large national database in America and revealed that the median OS time was 25 months. Gogna et al 28 studied 482 patients with gallbladder NEN from the SEER database and found that the mean survival time was 37.11 months. In addition to survival time, reports on survival rates vary widely.…”

Section: Discussionmentioning

confidence: 99%

“…Another SEER database study also revealed that age, tumor stage, extension, and grade were associated with the outcomes. 28 Adjuvant therapy has also been associated with improved OS rates. 9 This study compared patients according to their age, sex, tumor size, and tumor nature; however, no significant difference in prognosis was found.…”

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Hong

et al. 2023

Cancer Medicine

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Background Neuroendocrine neoplasm (NEN) of the gallbladder is rare. It is usually asymptomatic and occurs in older adults. Its clinicopathological characteristics remain controversial, and the diagnosis and treatment strategies are usually based on models of adenocarcinoma. The present study aimed to investigate the clinical characteristics and prognosis of gallbladder NEN. Methods The data of patients with gallbladder NEN admitted to Peking Union Medical College Hospital was reviewed, and a database was established for retrospective analysis. Clinicopathological features were analyzed descriptively and the prognosis was studied according to different factors. The Kaplan–Meier curve was used to describe the cumulative survival rate. Results In total, 22 patients with gallbladder NEN were included in this study. There were 10 male (45.5%) and 12 female (54.5%) patients with a median age of onset of NEN at 57.5 (49.0, 62.3) years. Abdominal discomfort was the most common symptom. Twenty patients (90.9%) underwent surgery, and two patients (9.1%) with unresectable lesions underwent a biopsy. Twenty‐one patients were followed up. The 1‐, 2‐, and 3‐year cumulative overall survival rates of all patients and patients with resectable lesions were 65.9%, 54.9%, and 48.1%, and 72.9%, 60.7%, and 53.1%, respectively. Patients with resectable lesions had a better cumulative overall survival rate than those who with unresectable lesions (p < 0.001). Conclusion Gallbladder NEN is more common in the elderly and has a slight female predominance. The most common symptom is abdominal discomfort. Surgery is the first choice of treatment for this rare disease. The prognosis of gallbladder NEN is generally poor. Patients with resectable lesions have a better prognosis.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Hong

et al. 2023

Cancer Medicine

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“…The prognosis of GB-NEC is very poor and the recurrence risk is very high. 5 Very few pure LCNEC have been reported in the literature with a median survival of 8 to 10 months, so it becomes very difficult to propose the best management plan. 3 , 7 Still, surgical resection improves overall survival and is the cornerstone in the management of GB-NEC.…”

Section: Discussionmentioning

confidence: 99%

“… 3 , 7 Still, surgical resection improves overall survival and is the cornerstone in the management of GB-NEC. 5 For neuroendocrine tumours of GB, cholecystectomy could be enough if detected in early stages (in situ and T1 tumours). 5 , 6 Extended cholecystectomy (including GB, adjacent liver segments IVB & V along with adequate lymphadenectomy) should be the first line of treatment in patients with advanced GB-NEC without distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Large Cell Neuroendocrine Carcinoma of Gallbladder: A Case Report

Sah,

Shrestha

2024

J Nepal Med Assoc

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Large cell neuroendocrine carcinoma of the gallbladder is an extremely rare tumour with aggressive behaviour and a bad prognosis. Here, we report a case of a 65-year-old lady suspected of carcinoma of the gallbladder and underwent extended cholecystectomy. The histopathology report revealed neuroendocrine carcinoma of a large cell type of gall bladder infiltrating the liver and three periportal and pericholedochal lymph nodes. She had an uneventful perioperative period and was doing good till 6 months of follow-up. The only potentially curative treatment for large cell neuroendocrine carcinoma of the gallbladder is aggressive surgical resection, owing to its aggressive behaviour and bad prognosis.

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Neuroendocrine neoplasms of the gallbladder: A single institute analysis of outcomes and prognostic factors

Nandy,

Patkar,

Yadav

et al. 2024

Journal of Surgical Oncology

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IntroductionNeuroendocrine neoplasms (NENs) are classified as neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine and nonneuroendocrine neoplasms (MiNENs) according to World Health Organization classification. We present our experience of NENs of the gallbladder (GB) from a high‐volume cancer hospital.Materials and MethodsThe present study is a retrospective analysis of all patients with GB NENs who presented between January 2015 and June 2023. The patient details and treatment received with follow‐up were noted. The primary endpoint was overall survival (OS).ResultsA total of 147 patients were included in the study. The median age was 52 (27–81) years. There was a female predominance (70.7%). NEC was the most common subtype (84.4%) followed by MiNEN (12.9%) and NET (2.7%). The most common stage at presentation was metastatic (70.7%) followed by locally advanced (21.8%), and early disease (7.5%). The median follow‐up was 9.92 (1.77–76.06) months. Median OS was 6.14 (3.93–8.35) months. Median OS in patients who received multimodality treatment was 20.20 (17.99–22.41) months versus 4.00 (2.91–5.10) months in those who did not receive it.ConclusionGB NENs are rare, but aggressive tumors with NEC being the most common type. Multimodality treatment yields favorable outcomes. However, the development of better systemic therapy is needed to help improve survival further.

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Neuroendocrine neoplasms of the gallbladder: early detection and surgery is key to improved outcome

Cited by 7 publications

References 32 publications

Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Large Cell Neuroendocrine Carcinoma of Gallbladder: A Case Report

Neuroendocrine neoplasms of the gallbladder: A single institute analysis of outcomes and prognostic factors

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