Neuroendocrine Factors in Melanoma Pathogenesis

Scheau, Cristian; Drăghici, Carmen; Ilie, Mihaela; Lupu, Mihai; Solomon, Iulia; Tampa, Mircea; Georgescu, Simona Roxana; Căruntu, Ana; Constantin, Carolina; Neagu, Monica; Căruntu, Constantin

doi:10.3390/cancers13092277

Cited by 20 publications

(20 citation statements)

References 336 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high level of vitamin D is associated with a low tumoral thickness and protects against relapses and death caused by melanoma [ 45 , 61 ]. Some studies suggest that neuroendocrine factors may play a role in melanoma development, influencing the tumoral cells’ proliferation and metastasis capability [ 62 ]. For example, catecholamines stimulate proliferation, motility, and invasion of melanoma cells, while glutamate may activate angiogenesis [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

Review: The Key Factors to Melanomagenesis

Mihulecea

Rotaru

2023

Life

View full text Add to dashboard Cite

Melanoma is the most dangerous form of skin cancer that develops from the malignant transformation of the melanocytes located in the basal layer of the epidermis (cutaneous melanoma). Melanocytes may also be found in the meninges, eyes, ears, gastrointestinal tract, genito-urinary system, or other mucosal surfaces (mucosal melanoma). Melanoma is caused by an uncontrolled proliferation of melanocytes, that at first may form a benign lesion (nevogenesis), but in time, it may transition to melanoma, determining what it is named, melanomagenesis. Some tumors may appear spontaneously (de novo melanoma) or on preexisting lesions (nevus-associated melanoma). The exact cause of melanoma may not be fully understood yet, but there are some factors that initiate and promote this malignant process. This study aims to provide a summary of the latest articles regarding the key factors that may lead to melanomagenesis. The secondary objectives are to reveal the relationship between nevi and melanoma, to understand the cause of “de novo” and “nevus-associated melanoma” and highlight the differences between these subtypes.

show abstract

Section: Resultsmentioning

confidence: 99%

Review: The Key Factors to Melanomagenesis

Mihulecea

Rotaru

2023

Life

View full text Add to dashboard Cite

show abstract

“…However, it can be obviously assumed that, along with the studied components of the secretome, specific proteases, which entered the extracellular matrix, also exerted their effects. It is also necessary to consider the components of the secretome with neuroendocrine effects, namely, histamine, VEGF, IL-8, heparin, and TGF-β [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Protease Profile of Tumor-Associated Mast Cells in Melanoma

Atiakshin

Kostin

Buchwalow

et al. 2022

IJMS

View full text Add to dashboard Cite

Mast cells (MCs) produce a variety of mediators, including proteases—tryptase, chymase, and carboxypeptidases—which are important for the immune response. However, a detailed assessment of the mechanisms of biogenesis and excretion of proteases in melanoma has yet to be carried out. In this study, we present data on phenotype and secretory pathways of proteases in MCs in the course of melanoma. The development of melanoma was found to be accompanied by the appearance in the tumor-associated MC population of several pools with a predominant content of one or two specific proteases with a low content or complete absence of others. Elucidation of the molecular and morphological features of the expression of MC proteases in melanoma allows us a fresh perspective of the pathogenesis of the disease, and can be used to clarify MCs classification, the disease prognosis, and evaluate the effectiveness of ongoing antitumor therapy.

show abstract

“…Combining this with the study that found TSH can promote the growth of melanoma by triggering the formation of cAMP and activating the mitogen-activated protein kinase (MAPK) signaling pathway, may in part account for the high prevalence of hypothyroidism (elevated TSH lever) in the melanoma population [48,49]. Intriguingly, another study has reported that suppression of MAP kinase and PI3KAkt pathways exhibits their anti-melanoma effects, including suppression of cell proliferation, transformation, and invasion, and these effects are coupled with inducing the expression of thyroid genes, such as TSH-R and NIS, and consequently increasing radioiodide uptake by melanoma cells, which may prove to be a novel approach to treating melanoma [50,51].…”

Section: Hypothalamic-pituitary-thyroid Axis (Hpt) Homologmentioning

confidence: 99%

Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis

Chen

Liu

Zhou

et al. 2022

Cells

View full text Add to dashboard Cite

Melanocytes produce melanin to protect the skin from UV-B radiation. Notwithstanding, the spectrum of their functions extends far beyond their well-known role as melanin production factories. Melanocytes have been considered as sensory and computational cells. The neurotransmitters, neuropeptides, and other hormones produced by melanocytes make them part of the skin’s well-orchestrated and complex neuroendocrine network, counteracting environmental stressors. Melanocytes can also actively mediate the epidermal immune response. Melanocytes are equipped with ectopic sensory systems similar to the eye and nose and can sense light and odor. The ubiquitous inner circadian rhythm controls the body’s basic physiological processes. Light not only affects skin photoaging, but also regulates inner circadian rhythms and communicates with the local neuroendocrine system. Do melanocytes “see” light and play a unique role in photoentrainment of the local circadian clock system? Why, then, are melanocytes responsible for so many mysterious functions? Do these complex functional devices work to maintain homeostasis locally and throughout the body? In addition, melanocytes have also been shown to be localized in internal sites such as the inner ear, brain, and heart, locations not stimulated by sunlight. Thus, what can the observation of extracutaneous melanocytes tell us about the “secret identity” of melanocytes? While the answers to some of these intriguing questions remain to be discovered, here we summarize and weave a thread around available data to explore the established and potential roles of melanocytes in the biological communication of skin and systemic homeostasis, and elaborate on important open issues and propose ways forward.

show abstract

Neuroendocrine Factors in Melanoma Pathogenesis

Cited by 20 publications

References 336 publications

Review: The Key Factors to Melanomagenesis

Review: The Key Factors to Melanomagenesis

Protease Profile of Tumor-Associated Mast Cells in Melanoma

Recognition of Melanocytes in Immuno-Neuroendocrinology and Circadian Rhythms: Beyond the Conventional Melanin Synthesis

Contact Info

Product

Resources

About