Neuroendocrine Cells in
Peripheral Prostatic Zone:
Age, Prostatic Intraepithelial
Neoplasia and Latent
Cancer-Related Changes

Algaba, Ferrán; Trias, Isabel; López, L. Saco; Rodríguez-Vallejo, José M.; González‐Esteban, Jorge

doi:10.1159/000475191

Cited by 12 publications

(3 citation statements)

References 10 publications

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“…Kovi and Jackson [34] reported that the high est frequency of involvement of the transition zone (37%) is in radical prostatectomies with cancer, while this find ing was significantly lower in studies utilizing transure thral resections. With regard to multifocality, PIN was reported to be multifocal in 72% of radical prostatecto mies with cancer, including 63% of those involving the nontransition zone and 7% of those involving the transi tion zone; 2% of the cases had concomitant single foci in all zones [6,[34][35][36][37],…”

Section: Age and Racial Distribution Of Prostatic Intraepithelial Neomentioning

confidence: 99%

Age and Racial Distribution of Prostatic Intraepithelial Neoplasia

et al. 1996

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Section: Age and Racial Distribution Of Prostatic Intraepithelial Neomentioning

confidence: 99%

Age and Racial Distribution of Prostatic Intraepithelial Neoplasia

et al. 1996

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“…High-grade prostatic intraepithelial neoplasia (PIN) is considered the precursor of prostate cancer (PCa) of the peripheral zone [1,10,21,25,29,30,31]. These studies have shown that there are close similarities from the morphological, immuno-histochemical, and molecular points of view between high-grade PIN and PCa.…”

Section: Introductionmentioning

confidence: 99%

Nuclear changes in the normal-looking columnar epithelium adjacent to and distant from prostatic intraepithelial neoplasia and prostate cancer

et al. 2000

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Subtle morphological changes and molecular alterations have been reported in normal-appearing tissue in prostates with high-grade prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa). The severity and the distribution of these changes and alterations within the prostate gland have not been addressed in previous publications. The aim of this study was to investigate morphometrically the nuclear changes of the normal-looking columnar epithelium adjacent to and distant from high-grade PIN and PCa. Karyometry was performed on the whole-mount histological sections of three radical prostatectomy (RP) specimens. Two concentrical lines, one corresponding to the outer surface (or capsule) of the prostate and the other corresponding to one centimeter towards the center, were drawn with a black pen on each whole-mount section. The part of the prostate tissue between these two boundaries was then divided into twelve equal sectors or regions. The part within the inner line was divided into two regions. The analysis was also performed on the slides of the apex and base of the prostate. One prostate contained normal-looking epithelium only (case no. 1). Another contained both high-grade PIN and PCa, the former occupying larger areas than the latter (case no. 2). Both high-grade PIN and PCa were present in the third sample, in which PCa was more widely distributed than PIN (case no. 3). The lesion measured in each region was always the most severe, e.g., either high-grade PIN or PCa. When neither were identifiable, then the normal-looking columnar epithelium was analyzed. For each sector, the mean and standard deviation of the nuclear area, maximum nuclear diameter, nuclear roundness factor, and nucleolar area were calculated. In normal-looking columnar epithelium, the mean of the mean nuclear area of the sectors of case no. 1 was 35.19 microm2 (SD 4.14). The mean nuclear areas in cases no. 2 and no. 3 were 37.94 microm2 (SD 4.65) and 37.31 microm2 (SD 4.36), respectively. The mean of the mean nuclear area of the sectors with high-grade PIN of case no. 2 was 49.85 microm2 (SD 8.44), whereas it was 54.26 microm2 (SD 2.91) in case no. 3. The mean of the nuclear area values obtained in the sectors of cases no. 2 and no. 3 with PCa was 56.74 microm2 (SD 6.56) and 61.17 microm2 (SD 8.13), respectively. When considering the normal-looking tissue of the second and third case, 79% and 90%, respectively, of the regions showed nuclear area values greater than 34.94 microm2 (e.g., the 50th percentile of the mean nuclear area values of the regions of the first case). Sectors with normal-looking epithelium, whose nuclear area was above this threshold, were both adjacent to and at a distance of more than 1 cm from those with PIN or PCa. The other nuclear features showed a similar trend of value changes. This study demonstrates that the normal-looking ducts and acini from prostate harboring preneoplastic and neoplastic lesions show morphological nuclear abnormalities that are not seen by the human eyes but that can be detected w...

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“…[65][66][67][68][69] Little attention has been paid in the literature to the identification of the transition between high grade PIN and carcinoma. This topic was considered by McNeal et al in a paper dealing with microcarcinoma in the prostate and its association with duct-acinar dysplasia.…”

Section: Effect Of Androgen Deprivation On Pinmentioning

confidence: 99%

Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance

Montironi

2000

Journal of Clinical Pathology

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High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN. (J Clin Pathol 2000;53:655-665)

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Neuroendocrine Cells in Peripheral Prostatic Zone: Age, Prostatic Intraepithelial Neoplasia and Latent Cancer-Related Changes

Cited by 12 publications

References 10 publications

Age and Racial Distribution of Prostatic Intraepithelial Neoplasia

Age and Racial Distribution of Prostatic Intraepithelial Neoplasia

Nuclear changes in the normal-looking columnar epithelium adjacent to and distant from prostatic intraepithelial neoplasia and prostate cancer

Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance

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