Neuroendocrine carcinomas of the larynx: what do the different histologic types really mean?

Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature

“…Recently, in June 2010, another classification was proposed by Devaney et al3 only for the neuroendocrine carcinomas (excluding paraganglioma). This classification is based on their behavior and segregates laryngeal neuroendocrine tumors into 3 types: grade I: neuroendocrine carcinomas (the carcinoid tumors), grade II: neuroendocrine carcinomas (the atypical carcinoids), and grade III: neuroendocrine carcinomas (encompassing 2 subtypes: the small cell neuroendocrine carcinomas, and the large cell neuroendocrine carcinomas).…”

Small Cell Neuroendocrine Carcinoma of the Larynx: A Case Report and Literature Review

“…The tumor strongly stains with cytokeratin, epithelial membrane antigen, chromogranin, synapthopysin, and somatostatin. There is no necrosis in atypical carcinoid [8]. There were tumor nests in the lamina propria in our case (Figure 3).…”

Terminology and classification of neuroendocrine neoplasms of the larynx

“…Large‐cell neuroendocrine carcinoma is a type that has been of considerable discussion recently. 40 In the past decade, a few case reports and one series of this rare entity have been published. 8, 33, 41, 42 These tumors were classified as such based on the pulmonary WHO criteria for large‐cell neuroendocrine carcinoma, 34 and the authors considered them to be high grade akin to small‐cell neuroendocrine carcinoma.…”