Neuroendocrine carcinoma of the skin with a lymphoepithelioma-like histological pattern

Ríos-Martín, Juan José; Solorzano-Amoreti, A.; González‐Cámpora, Ricardo; Galera-Davidson, H

doi:10.1046/j.1365-2133.2000.03690.x

Cited by 17 publications

(7 citation statements)

References 10 publications

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“…1 Cases of Merkel cell (neuroendocrine) carcinoma with a lymphoepithelioma-like pattern have also been reported. 4 As previously suggested, 5 we hypothesize that LELCS is a morphological pattern rather than a distinct carcinoma. Taking the histopathological result into account, external dental fistula or mycobacterial infection was included as differential diagnosis.…”

supporting

confidence: 61%

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Gille

Miles

Mitchell

2012

Case Reports in Oncological Medicine

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Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm microscopically similar to undifferentiated nasopharyngeal carcinoma. It is typically nonaggressive and is treated with wide local excision. However, we present a case of a patient with a regional recurrence and more aggressive LELCS with perineural invasion and positive margins for which he was treated with wide local excision followed by chemoradiation. We discuss the use of chemoradiation for this patient and review the literature, specifically pertaining to treatment of more aggressive cases of LELCS.

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supporting

confidence: 61%

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Gille

Miles

Mitchell

2012

Case Reports in Oncological Medicine

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“…Merkel cell carcinoma with large-cell features has been reported in 3 cases out of 20 (15%), 2 29 cases out of 132 (22%), 3 and 2 individual cases. 5,6 Dotlike positivity for CK20 has not always been identified in cases reported as Merkel cell carcinoma. 2,3 The same was true in our cases.…”

Section: Discussionmentioning

confidence: 95%

Large-cell Neuroendocrine Carcinoma of the Skin, With Lymphoid Stroma

Kasami

Muramatsu²,

Kawahata³

et al. 2007

The American Journal of Dermatopathology

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We report two cases of a large-cell neuroendocrine carcinoma of the skin as a distinct histological category. The patients are a 63-year-old woman with a 7-mm reddish round nodule on her nose for 4 months, and a 95-year-old man with several hemorrhagic nodules on the external ear for 28 months. The first patient had two positive sentinel lymph nodes. The tumors from both patients consisted of islands of pleomorphic large cells within a lymphoid stroma.

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“…In our case, histological findings of the skin tumor did not suggest MCC. The second reported case was documented, two years later, by Rios-Martin et al [10]. Some cases of MCC with a marked lymphocytic host response suggesting a lymphomatous proliferation have been reported.…”

Section: Discussionmentioning

confidence: 96%

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Abdelkrim

Dhouibi

Moussa

et al. 2011

Case Reports in Pathology

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Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithelial component associated with a dense lymphoid stroma. Rarely, MCC shows a marked lymphocytic host response or can even mimic a LEL carcinoma. We report a new case of MCC mimicking an LEL carcinoma in a 72-year-old male; the diagnosis of MCC was made on the basis of the morphology and immunohistochemical findings. We present through this case an exceptional pattern of MCC which can be misleading, and we insist on differential diagnoses.

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Neuroendocrine carcinoma of the skin with a lymphoepithelioma-like histological pattern

Cited by 17 publications

References 10 publications

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Large-cell Neuroendocrine Carcinoma of the Skin, With Lymphoid Stroma

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

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