Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Gille, Theresa; Miles, Edward F.; Mitchell, Allen O.

doi:10.1155/2012/241816

Cited by 14 publications

(38 citation statements)

References 13 publications

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“…Additionally, current strategies for cancer treatment vary, including surgery, chemotherapy, radiation therapy, and palliative care, among which radiotherapy and chemotherapy are more wildly used in the therapy of human cancer [5,6]. A large number of studies showed that the use of CRT, which is the combination of radiotherapy and chemotherapy is well described for cancer treatment [7,8]. Moreover, a large number of previous studies also revealed that some intrinsic genetic factors have significant influence on the prognosis of CRT [9,10].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Prognostic value of CD133 expression in cancer patients treated with chemoradiotherapy: a meta-analysis

Zhai

et al. 2014

Tumor Biol.

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Many studies evaluated the correlations of CD133 expression with the clinical outcomes in patients treated with chemoradiotherapy (CRT) but yielded controversial results. This meta-analysis was performed to identify the impacts of CD133 expression on the prognosis of cancer patients treated with CRT. Electronic databases updated up to March 2014 were searched to find relevant studies. Relevant literatures without any language restrictions were searched via electronic databases as follows: Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). STATA software was used for the current meta-analysis. Hazard ratios (HR) and its corresponding 95% confidence interval (95% CI) were calculated. Six studies were identified with a total of 470 cancer patients treated with CRT. The meta-analysis results showed that CD133-positive patients had poorer overall survival (OS) than that of CD133-negative patients (HR = 2.13, 95% CI = 1.20 ~ 3.07, P < 0.001). Furthermore, CD133-positive patients displayed shorter disease-free survival (DFS) than that of CD133-negative patients (HR = 1.74, 95% CI = 0.08 ~ 3.40, P = 0.039). Ethnicity-stratified analysis indicated that CD133 expression positively correlated with shorter OS among the Japanese, Chinese, and Spanish populations (all P < 0.05). In conclusion, our findings suggest that CD133 expression may be positively correlated with poorer prognosis in cancer patients treated with CRT.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Prognostic value of CD133 expression in cancer patients treated with chemoradiotherapy: a meta-analysis

Zhai

et al. 2014

Tumor Biol.

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“…These tumors are reported to occur in several organs, including nasopharynx, 3 salivary glands, 4 lungs, 5,6 and stomach, 7 and also have been uncommonly reported in trachea, 8 lacrimal glands, 9 ureters, 10 urinary bladder, 11,12 uterine cervix, 13 vagina, 14 ovaries, 15 breast, 16 soft tissue, 17 and skin. 18 Epstein-Barr virus (EBV) has been shown to be strongly associated with LELCs of the nasopharynx, 19 stomach, 20 salivary glands, 4 lungs, 5,6 and thymus 21 in the form of integration of the viral genome in the tumor cell nuclei. However, this association has not been shown in LELCs of the urinary bladder, 11 uterine cervix, 22,23 or skin.…”

mentioning

confidence: 99%

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

Patel

Liu

Vaccharajani

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The World Health Organization has recently recognized lymphoepithelioma-like carcinoma, or inflammatory hepatocellular carcinoma, as a variant of hepatocellular carcinoma.Objective.-To identify and characterize the inflammatory hepatocellular carcinomas in our institution from 1988 to the present.Design.-All cases of hepatocellular carcinoma in our institution from 1988 to the present were reviewed and reclassified as lymphoepithelioma-like carcinoma and were studied in comparison to appropriately matched controls.Results.-Among the 8 cases of lymphoepithelioma-like carcinoma identified, the male to female ratio was 1:3, the mean age was 68.5 years (range, 57-78 years), and all of the cases were seen in noncirrhotic livers. The average numbers of lymphocytes were significantly higher in the cases than in the controls. T cells were predominant, with a uniform distribution of CD4 and CD8 positive cells. Cholangiolar differentiation was seen by K19 positivity as focal in 1 case and diffuse in 2 cases. In situ hybridization for Epstein-Barr virus was negative in all of the cases. Diffuse overexpression of p16 (.75% of cells) was seen in 2 cases, both of which were negative for the presence of transcriptionally active human papilloma virus by in situ hybridization. In our series, 3 of 8 cases (37.5%) showed local recurrence, which was similar to the controls (6 of 18; 33%), P . .99. Although the rate of distant metastases was lower among the cases (12.5%) than the controls (22.2%), the difference was not statistically significant (P . .99).Conclusion.-We present the first series of 8 cases of lymphoepithelioma-like carcinoma of the liver occurring in patients without cirrhosis and with a female preponderance and the absence of Epstein-Barr virus. Although clinical outcomes were similar to those of controls in our small series, additional data may be required for confirmation.

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“…DLBK en sık baş-boyun bölgesinde görülür ve olguların %90'ında yüz yerleşimi bildirilmiştir. Tümör gövde ve çok nadiren ekstremitelerde de ortaya çıkabilir 6,7 . Literatürde tam yeri belirtilmeksizin 2 hastada kolda yerleşen lezyon bildirilmiştir 1 .…”

Section: Discussionunclassified

“…DLBK'nin klinik özellikleri tipik olmadığından, tanı oldukça zordur. Genellikle 0,4-4,5 cm arası değişen çaplarda, deri renginde veya kırmızı, sert soliter papül, nodül veya plak şeklinde ortaya çıkar 7 . Sıklıkla, aylar yıllar içinde büyüyen asemptomatik lezyon öyküsü bulunur.…”

Section: Discussionunclassified

“…Bu lenfositler immünhistokimyasal olarak çoğunlukla T hücre fenotipi gösterir. Epidermisle bağlantısı olmasa bile, immünhistokimyasal olarak neoplastik hücrelerde sitokeratin ve epitelyal membran antijeninin çoğunlukla pozitif saptanması, epidermal orijini düşündürmektedir 2,7 . Hastamızın lezyonundan yapılan biyopsi ve bunu izleyen eksizyonun histopatolojik incelemesinde yukarıda tanımlanan tipik histolojik bulgular, epidermis ile ilişki, immünhistokimyasal incelemede pansitokeratin ve epitelyal membran antijeni pozitifliği saptanarak DLBK tanısı kondu.…”

Section: Discussionunclassified

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A rare cutaneous malignancy with poorly described clinical features: Lymphoepithelioma-like carcinoma of the skin

Mehdi¹,

Büyükbabanı²,

Ekinci³

et al. 2015

TURKDERM

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Lymphoepithelioma-like carcinoma can be originated from different organs, including nasopharynx, larynx, stomach, salivary glands, lung, thymus, cervix and bladder. Lymphoepithelioma-like carcinoma of the skin is a rare malignancy with low metastatic potential and is defined by a histologic picture simulating indifferentiated nasopharynx carcinoma. There are only a few case reports in the literature and the clinical features of the tumor are not well described. It presents usually with flesh-colored or reddish firm nodules and plaques which are nonspecific. The head and neck region is the predilection site of the tumor, but it can be seen in many other areas. We present here an 84-year-old male admitted to the dermatovenereology department with a slowly growing purplish-red asymptomatic plaque, 2x2 cm in diameter which was diagnosed as lymphoepithelioma-like carcinoma of the skin upon histopathologic examination. The tumor was excised and metastasis was not detected. Local recurrence was not observed in a one-year follow-up period. Lymphoepithelioma-like carcinoma of the skin should also be considered in the clinical differential diagnosis of slowly growing solitary nodules and infiltrated plaques. An other important feature of our case was the arm localization of the tumor which has been very rarely reported. (Turkderm 2015; 49: 229-31) Key Words: Lymphoepithelioma-like carcinoma of the skin, malignant skin tumor, anti-pan-cytokeratin antibody Lenfoepitelyom benzeri karsinom deri, nazofarenks, mide, tükrük bezi, akciğer, timus, serviks, larinks ve mesane gibi birçok organda ortaya çıkabilen bir tümördür. Derinin lenfoepitelyom benzeri karsinomu düşük metastaz potansiyeli olan, histopatolojik olarak indiferansiye nazofarenks karsinomuna benzeyen primer deri tümörüdür. Literatürde bildirilen olgu sayısı çok az olup, deri renginde veya kırmızı, sert nodül veya infiltre plak şeklinde lezyonlara yol açtığı bildirilmiş ve özgün klinik bulguları tanımlanmamıştır. Çoğunlukla baş boyun bölgesinde yerleşir. Seksen dört yaşında erkek hastanın bir yıldır sağ ön kolda yerleşen, yavaş büyüyen yaklaşık 2x2 cm boyutlarında asemptomatik morumsu kırmızı infiltre plak lezyonuna histopatolojik incelemede derinin lenfoepitelyom benzeri karsinomu tanısı kondu. Metastaz saptanmayan olguda eksizyon sonrası bir yıllık izlem süresinde nüks gözlenmedi. Olgumuzun klinik bulguları ve seyrini göz önünde bulundurarak, yaşlılıkta ortaya çıkan yavaş progresif seyirli soliter nodül ve plakların ayırıcı tanısına derinin lenfoepitelyom benzeri karsinomunun da alınması gerektiğine dikkat çekmek istiyoruz. Ayrıca olgumuzun lezyonu bu tümör için daha önce çok nadir bildirilmiş kol lokalizasyonu ile de önem taşımaktadır. (Türk derm 2015; 49: 229-31) Anahtar Kelimeler: Derinin lenfoepitelyom benzeri karsinomu, malign deri tümörü, anti-pansitokeratin antikoru

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Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Cited by 14 publications

References 13 publications

RETRACTED ARTICLE: Prognostic value of CD133 expression in cancer patients treated with chemoradiotherapy: a meta-analysis

RETRACTED ARTICLE: Prognostic value of CD133 expression in cancer patients treated with chemoradiotherapy: a meta-analysis

Characterization of Inflammatory (Lymphoepithelioma-like) Hepatocellular Carcinoma: A Study of 8 Cases

A rare cutaneous malignancy with poorly described clinical features: Lymphoepithelioma-like carcinoma of the skin

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