Neuroendocrine Carcinoma Arising in a Mediastinal Teratoma with Pulmonary Metastasis: A Case Report and the Chemotherapy Response

Abstract

Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.

Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope

“…STM is defined as a germ cell tumor accompanied by a nongerm cell tumor such as sarcoma, carcinoma, leukemia, or lymphoma. STM is rare and is observed in ~2-3% of all male germ cell tumors and about one-third occur in the mediastinum [ 1 – 5 ]. In STM, neuroendocrine carcinoma is extremely rare [ 1 ].…”

“…STM is rare and is observed in ~2-3% of all male germ cell tumors and about one-third occur in the mediastinum [ 1 – 5 ]. In STM, neuroendocrine carcinoma is extremely rare [ 1 ]. Mature teratomas represent approximately 60% to 75% of mediastinal germ cell tumors [ 6 , 7 ].…”

“…Neuroendocrine tumors that arise in an extragonadal teratoma are extremely rare [ 1 ]. To the best of our knowledge, very few cases of a neuroendocrine tumor arising in the thoracic cavity as a teratoma have been previously reported [ 1 – 3 ]. Somatic-type malignancy (STM), defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors.…”

“…Somatic-type malignancy (STM), defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. In STM, neuroendocrine carcinoma is extremely rare [ 1 ]. In our case, we report a thoracic teratoma with neuroendocrine elements which was found incidentally on thoracic CT-scan of a 34-year-old male patient who presented with multiple episodes of syncope.…”

Mature teratoma with somatic-type solid malignancy in the mediastinum: A case report of rare and poor prognosis tumour

“…Somatic-type solid malignancies can occur in primary germ cells tumor or only in metastases. 8,9,10, 11 The epithelial malignancies associated with germ cells tumor are mostly colonic type adenocarcinomas, adenosquamous carcinoma, and squamous cell carcinoma. 7 This paper reported the case of a 19 years old female diagnosed with a mediastinal tumor, suspicious of teratoma.…”