Neurodevelopmental outcome of infants with acute lymphoblastic leukemia

Kaleita, Thomas A.; Reaman, Gregory H.; MacLean, William E.; Sather, Harland N.; Whitt, J. Kenneth

doi:10.1002/(sici)1097-0142(19990415)85:8<1859::aid-cncr28>3.0.co;2-2

Cited by 48 publications

(20 citation statements)

References 19 publications

(26 reference statements)

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“…These findings oppose those reported by von der Weid et al (2) and Kaleita et al (3) who found no evidence of cognitive delays amongst their childhood cancer survivors. Coombs et al eight months below the children's mean actual age.…”

Section: Discussioncontrasting

confidence: 83%

“…One study by von der Weid et al found that "as a group, ALL [acute lymphoblastic leukaemia] survivors showed intellectual performances within the normal range and was comparable to survivors from solid tumours outside the central nervous system [CNS]" (2). Another study by Kaleita et al also found that "mean scores on all cognitive and motor indices of the McCarthy scales were in the average range", concluding a generally positive neurodevelopmental outcome (3). However, other studies have shown that children who survived leukaemia typically obtained lower IQ scores than matched healthy children or children treated for solid tumours outside the CNS (4).…”

Section: Introductionmentioning

confidence: 99%

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Neurodevelopmental Outcome of Childhood Cancer Survivors Treated at the Eric Williams Medical Sciences Complex

2014

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Outcome of Childhood Cancer Survivors Treated at the Eric Williams Medical Sciences Complex

2014

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“…Although intensive CNS-directed chemotherapy may also adversely affect the immature CNS, 28,35,37 its impact is likely to be less than that of CRT. Indeed, Kaleita et al 38 recently showed a substantial improvement in neurodevelopmental outcomes of infant leukemia survivors evaluated at a mean age of 5 years who were treated on the CCG107 protocol that does not include CRT. In our study, only one of the 10 patients (in group A) who did not receive CRT has academic difficulties.…”

Section: Discussionmentioning

confidence: 99%

Late effects in survivors of infant leukemia

et al. 2000

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Little is known about the incidence of and risk factor for late effects of infant leukemia. We evaluated 19 children with acute lymphoblastic leukemia and 15 with acute myeloid leukemia who were diagnosed at age 12 months or younger and have survived for more than 5 years after the diagnosis (median length of follow-up, 13 years; range, 5.7-29 years). Ten patients received chemotherapy alone (group A), 17 received chemotherapy and CNS-directed radiation therapy (CRT) (group B), and seven received chemotherapy, CRT and bone marrow transplantation (group C). The most frequently observed late sequelae included problems in growth (66% of survivors), learning (50%), hypothyroidism (15%), and pubertal development (12%). Cataract, cardiac and hearing abnormalities occurred in 6% of patients. Only eight patients (24%) survive without late effects. In comparison to patients in group A, patients in groups B and C had a higher incidence of having at least one late complication (P = 0.009), a greater decrease in height Z score at 5 years after diagnosis (P = 0.023), and a higher incidence of academic difficulties (P = 0.004). The estimated odds of academic difficulties increased by 18% (P = 0.032) for each month younger in age at the time of CRT. These results indicate that late sequelae are common in longterm survivors of infant leukemia and are often related to CRT and the patient's age at the time of CRT. Leukemia (2000) 14, 1185-1190.

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“…[9][10][11] Cranial RT as well as intrathecal chemotherapy results in these complications. [12][13][14][15] Comparison of the effects of various therapeutic approaches has resulted in reduction in the neurotoxicity of various regimens. 8,16 Brouwers and Poplack 17 reported that attention deficits represented the main variable by which diminished skills in memory tests could be explained in ALL patients.…”

Section: Introductionmentioning

confidence: 99%