Neurodevelopmental and neuropsychiatric disorders affecting multisensory processes

Cascio, Carissa J.; Simon, David M.; Bryant, Lauren K.; DiCarlo, Gabriella E.; Wallace, Mark T.

doi:10.1016/b978-0-12-812492-5.00017-6

Cited by 7 publications

(7 citation statements)

References 145 publications

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“…Furthermore, although an overview of multisensory integration (MI—the ability to integrate information from different sensory sources) 94 is beyond the scope of this paper, it is important to consider MMHs in light of recent evidence on multisensory processing. MI involves several brain areas and networks, starting as early as in the superior colliculus.…”

Section: Unanswered Questions and Recommendationsmentioning

confidence: 99%

“…MI involves several brain areas and networks, starting as early as in the superior colliculus. 95 A growing body of evidence attests to: (1) MI problems in schizophrenia both for low-level stimuli 96 and more complex ones, 97 indicating issues with faulty “binding” of stimuli in time and/or space, 94 and (2) a link between these issues and hallucinations. 98 Similarly, PDP patients with hallucinations have problems with the integration of perceptual and attentional processing.…”

Section: Unanswered Questions and Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Montagnese

Leptourgos

Fernyhough

et al. 2020

Schizophrenia Bulletin

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Hallucinations can occur in different sensory modalities, both simultaneously and serially in time. They have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Hallucinatory experiences occurring in multiple sensory systems—multimodal hallucinations (MMHs)—are more prevalent than previously thought and may have greater adverse impact than unimodal ones, but they remain relatively underresearched. Here, we review and discuss: (1) the definition and categorization of both serial and simultaneous MMHs, (2) available assessment tools and how they can be improved, and (3) the explanatory power that current hallucination theories have for MMHs. Overall, we suggest that current models need to be updated or developed to account for MMHs and to inform research into the underlying processes of such hallucinatory phenomena. We make recommendations for future research and for clinical practice, including the need for service user involvement and for better assessment tools that can reliably measure MMHs and distinguish them from other related phenomena.

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Section: Unanswered Questions and Recommendationsmentioning

confidence: 99%

Section: Unanswered Questions and Recommendationsmentioning

confidence: 99%

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Montagnese

Leptourgos

Fernyhough

et al. 2020

Schizophrenia Bulletin

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show abstract

“…These findings provide a neural mechanism through which the fly achieves a conceptual equivalent of hippocampus-dependent pattern completion in mammals, in which partial scenes can retrieve a more complete memory representation 56 . Human patients with schizophrenia and autism exhibit deficits in multisensory integration 57 , and these conditions have been linked to serotonergic dysfunction and 5-HT 2A receptors 58 . Our work here suggests that inappropriate routing of multisensory percepts may contribute to these conditions.…”

Section: Discussionmentioning

confidence: 99%

Multisensory learning binds neurons into a cross-modal memory engram

Okray

Jacob

Stern

et al. 2023

Nature

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Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory expression are unknown. Here we demonstrate multisensory appetitive and aversive memory in Drosophila. Combining colours and odours improved memory performance, even when each sensory modality was tested alone. Temporal control of neuronal function revealed visually selective mushroom body Kenyon cells (KCs) to be required for enhancement of both visual and olfactory memory after multisensory training. Voltage imaging in head-fixed flies showed that multisensory learning binds activity between streams of modality-specific KCs so that unimodal sensory input generates a multimodal neuronal response. Binding occurs between regions of the olfactory and visual KC axons, which receive valence-relevant dopaminergic reinforcement, and is propagated downstream. Dopamine locally releases GABAergic inhibition to permit specific microcircuits within KC-spanning serotonergic neurons to function as an excitatory bridge between the previously ‘modality-selective’ KC streams. Cross-modal binding thereby expands the KCs representing the memory engram for each modality into those representing the other. This broadening of the engram improves memory performance after multisensory learning and permits a single sensory feature to retrieve the memory of the multimodal experience.

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“…These findings provide a neural mechanism through which the fly achieves a conceptual equivalent of hippocampus-dependent pattern completion in mammals, where partial cues are able to retrieve a more complete memory representation 50 . Interestingly, human patients with schizophrenia and autism exhibit deficits in multisensory integration 51,52 and these conditions have also been linked to serotonergic dysfunction and 5-HT2A receptor activity 53,54 . Our work here suggests that inappropriate routing of multisensory percepts may contribute to these conditions.…”

Section: Discussionmentioning

confidence: 99%

Multisensory learning binds modality-specific neurons into a cross-modal memory engram

Okray

Jacob

Stern

et al. 2022

Preprint

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Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory expression are unknown. Here we demonstrate multisensory appetitive and aversive memory in Drosophila. Combining colors and odors improved memory performance, even when each sensory modality was tested alone. Temporal control of neuronal function revealed visually-selective mushroom body Kenyon Cells (KCs) to be required for both enhancement of visual and olfactory memory after multisensory training. Voltage imaging in head-fixed flies showed that multisensory learning binds activity between streams of modality-specific KCs, so that unimodal sensory input generates a multimodal neuronal response. Binding occurs between regions of the olfactory and visual KC axons, which receive valence-relevant dopaminergic reinforcement, and is propagated downstream. Dopamine locally releases GABA-ergic inhibition to permit specific microcircuits within KC-spanning serotonergic neurons to function as an excitatory bridge between the previously modality-selective KC streams. Cross-modal binding thereby expands the olfactory memory engram by recruiting visual path KCs to become odor responsive. This broadening of the engram improves memory performance after multisensory learning and permits a single sensory feature to retrieve the memory of the multimodal experience.

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Neurodevelopmental and neuropsychiatric disorders affecting multisensory processes

Cited by 7 publications

References 145 publications

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Multisensory learning binds neurons into a cross-modal memory engram

Multisensory learning binds modality-specific neurons into a cross-modal memory engram

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