Neurodevelopment milestone abnormalities in rats exposed to stress in early life

Mesquita, Ana; Pêgo, José M.; Summavielle, Teresa; Maciel, Patrı́cia; Almeida, Osborne F. X.; Sousa, Nuno

doi:10.1016/j.neuroscience.2007.04.007

Cited by 69 publications

(47 citation statements)

References 52 publications

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“…31,33,38,41,45 In our study, no significant differences were detected between individually identified and control animals in the acquisition of postural reflex and 'negative geotaxis'. In the case of the surface righting reflex, a statistically significant difference was detected only when comparing the median postnatal day at which female Transponder and Control animals presented the mature reflex, but this was not verified for males.…”

Section: Postnatal Development Following Individual Markingcontrasting

confidence: 52%

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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The use of group-housed rodents in many fields of biomedical research imposes a need to identify individuals in a cage. Few studies have been designed to assess possible negative effects of identification methods of newborn mice on their development and wellbeing. In the present study, three different identification methods were applied to newborn C57BL/6J mice on postnatal day ( pnd) 5 (toe clipping, toe tattoo ink puncture and subcutaneous implantation of a small transponder). All identification methods used proved to be effective for long-term marking of individual animals. Newborn mice showed the least reaction to toe clipping followed by toe tattoo ink puncture and transponder implantation was the most distressful individual identification procedure in newborn mice. Importantly, clipped toe tissue proved to be enough for genotyping purposes. No overall consistent differences in somatic and neurological reflex development during the postnatal period were shown as a result of the newborn individual identification procedures used. Further, none of the methods interfered significantly with the adult animals' general normal behaviour (e.g. ability to move, grasp, climb) and sensory -motor functions as assessed with a simplified SHIRPA battery of tests, as well as Rotarod and Elevated Plus Maze tests. Postmortem thymus and adrenal gland weights gave no indication of chronic stress as a consequence of the identification method. We conclude that toe clipping might even be advisable in newborn mice at a very young age, when genotyping is needed. Toe tattoo ink puncture is also a good identification method for newborn mice and transponder implantation should only be used in older newborns or applied at weaning.

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Section: Postnatal Development Following Individual Markingcontrasting

confidence: 52%

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

et al. 2010

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“…Such treatments delay the acquisition of neurological reflexes (e.g. righting and postural reflexes, negative geotaxis) that depend on vestibular and cerebellar function (Ellenbroek et al 2005;Mesquita et al 2007), while advancing eye and ear opening. On the other hand, prenatal stress advances the time of ear-flap and eye opening (Secoli and Teixeira 1998).…”

Section: Programming Of Behavior By Early Life Stressmentioning

confidence: 99%

“…On the other hand, prenatal stress advances the time of ear-flap and eye opening (Secoli and Teixeira 1998). While these neurodevelopmental changes may reflect delayed myelination (Ferguson and Holson 1999;Murphy et al 2001;Valkama et al 2000), there is strong evidence for a role of altered catecholaminergic transmission in the vestibular region, the ventral tegmental area (VTA) and raphe nuclei (Mesquita et al 2007). Since these brainstem structures project to corticolimbic structures, it is plausible that their altered activity impacts on neuroendocrine (HPA axis activity) and behavioral functions.…”

Section: Programming Of Behavior By Early Life Stressmentioning

confidence: 99%

Potential programming of dopaminergic circuits by early life stress

et al. 2010

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Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical, and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.

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“…Erken gelişim döneminde karşılaşılabilecek olumsuz deneyimlerin patolojik sonuçlarından biri hipotalamik-pitüiter-adrenal eksenin (HPA) düzenlenmesinin bozulmasıdır 7,8 . HPA eksenin elamanlarının birbiriyle etkileşimi, dengeli homeostatik ortamın sağlanması için gereklidir.…”

Section: Anne Yoksunluğu Ve Hpa Eksen Arasındaki İlişkiunclassified

Deneysel Modellerde Anne Yoksunluğunun Beyin ve Davranışlar Üzerine Etkisi

Akıllıoğlu¹,

Karadepe²,

Binokay³

2014

Arşiv Kaynak Tarama Dergisi

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Adverse experiences in early developmental periods have significant effects on the adulthood behaviors. Maternal deprivation can be defined as prolonged loss of the care of the mother to the infant which may have intense and/or long continued even irreversible effects on the child's personality development. Maternal deprivation lead to structural, functional, neurochemical and behavioural alterations. The aim of this review is to examine the effects of maternal deprivation on the central nervous system and behavior in the light of current studies. Key words: Maternal deprivation, behaviour, central nervous system, neonatal. ÖZETErken gelişim döneminde yaşanan olumsuz deneyimler yetişkinlik dönemi davranışlarını etkilemektedir. Anne yoksunluğu, uzun süreli anne bakımından yoksun kalma sonucunda çocuğun kişilik gelişiminde geri dönüşümsüz ve şiddetli etkilerin olması şeklinde tanımlanmaktadır. Anne yoksunluğu, merkezi sinir sisteminde yapısal, hormonal, nörokimyasal ve davranışsal bir takım değişikliklere yol açmaktadır. Buyazıda, güncel çalışmalar ışığında, anne yoksunluğunun merkezi sinir sistemi ve davranışlar üzerindeki etkileri incelenmiştir. Anahtar kelimeler: Anne yoksunluğu, davranış, merkezi sinir sistemi, yenidoğan.

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Neurodevelopment milestone abnormalities in rats exposed to stress in early life

Cited by 69 publications

References 52 publications

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Identification methods in newborn C57BL/6 mice: a developmental and behavioural evaluation

Potential programming of dopaminergic circuits by early life stress

Deneysel Modellerde Anne Yoksunluğunun Beyin ve Davranışlar Üzerine Etkisi

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