Neurodegenerative Properties of Chronic Pain: Cognitive Decline in Patients with Chronic Pancreatitis

Jongsma, M.L.A.; Postma, Simone; Souren, Pierre M.; Arns, Martijn; Gordon, Evian; Vissers, Kris; Wilder‐Smith, O. H. G.; Rijn, Clementina M. van; Goor, Harry van

doi:10.1371/journal.pone.0023363

Cited by 50 publications

(42 citation statements)

References 59 publications

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“…The malnutrition which occurs as a result of EPI can be associated with a deterioration in brain function. Acute pancreatitis is often associated with encephalopathy (Zhang & Tian, 2007), whilst chronic pancreatitis is accompinied with ascending cognitive decline (Jongsma et al, 2011). Close monitoring of the operated pigs in the present study (during the development of EPI) revealed no signs of the pigs experiencing any pain or loss of appetite.…”

Section: Discussionmentioning

confidence: 41%

“…Pancreatic insufficiency is often associated with marked neurological alterations related to cognitive and sensory motor function (Jongsma et al, 2011). Many patients with chronic pancreatitis report symptoms that are associated with a decrease in cognitive function, such as depressive symptoms (Gallassi, Morreale, & Pagni, 2001;Gomez et al, 2006;Oosterman, Derksen, van Wijck, Veldhuijzen, & Kessels, 2011), sleep disturbances (Goel, Rao, Durmer, & Dinges, 2009) and the use of opioid medication (Sjogren, Thomsen, & Olsen, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Goncharova

Ушакова

Kovalenko

et al. 2015

Journal of Functional Foods

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Section: Discussionmentioning

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Goncharova

Ушакова

Kovalenko

et al. 2015

Journal of Functional Foods

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“…We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. attention-deficit hyperactivity disorder (ADHD; Aron and Poldrack 2005;Barkley 1997; Rubia et al 2001), schizophrenia (Enticott et al 2008;Kiehl et al 2000), obsessivecompulsive disorder and trichotillomania (Bohne et al 2008;Menzies et al 2007;Penadés et al 2007), Tourette syndrome (Ziemann et al 1997), chronic pain (Glass et al 2011;Jongsma et al 2011;Veldhuijzen et al 2012) and developmental stuttering (Eggers et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex

2015

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Stopping outright (reactive inhibition) and slowing down (proactive inhibition) are types of response inhibition which have mainly been investigated in the manual effector system. This study compared reactive inhibition across manual and vocal effector systems, examined the effects of excitatory anodal transcranial direct current stimulation (anodal tDCS) over the right prefrontal cortex (right-PFC) and looked at the relationship between reactive and proactive inhibition. We hypothesised (1) that vocal reactive inhibition would be less effective than manual reactive inhibition as evidenced by longer stop signal reaction times; (2) that anodal tDCS would enhance both vocal and manual reactive inhibitions and (3) that proactive and reactive inhibitions would be positively related. We tested 14 participants over two sessions (one session with anodal tDCS and one session with sham stimulation) and applied stimulation protocol in the middle of the session, i.e. only during the second of three phases. We used a stop signal task across two stop conditions: relevant and irrelevant stop conditions in which stopping was required or ignored, respectively. We found that reactive inhibition was faster during and immediately after anodal tDCS relative to sham. We also found that greater level of proactive inhibition enhanced reactive inhibition (indexed by shorter stop signal reaction times). These results support the hypothesis that the right-PFC is part of a core network for reactive inhibition and supports previous contention that proactive inhibition is possibly modulated via preactivating the reactive inhibition network.

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“…Among these complaints, memory is one of the most common and consistent (Epker & Ogden, 2013). Other factors, such as pain intensity and pain duration, have been shown to be positively correlated with objective measures of retrospective memory impairment in patients complaining of chronic orthopedic pain (Jongsma et al, 2011; Kreitler & Niv, 2007). However, severity of pain-related impairment is questionable.…”

mentioning

confidence: 99%

Pain is associated with prospective memory dysfunction in multiple sclerosis

Miller

Basso

Candilis

et al. 2014

Journal of Clinical and Experimental Neuropsychology

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Prospective memory (PM) pertains to the execution of a future goal or behavior. Initial research implies that people with multiple sclerosis (MS) are apt to show impaired prospective memory for activities of daily living (Rendell, Jensen, & Henry, 2007; Rendell et al., 2012). Yet, PM impairment does not occur in all people with MS. Thus, some other variable besides disease status alone may contribute to PM dysfunction in people with MS. Chronic pain may be such a variable. Approximately 50-70% of people with MS experience significant pain, and such pain has been thought to diminish memory function (Moore, Keogh, and Eccleston, 2009). To investigate this possibility, 96 patients with MS and 29 healthy subjects were administered the Memory for Intentions Screening Test (MIST) (Raskin, Buckheit, & Sherrod, 2010), a well-validated measure of prospective memory, and the Medical Outcomes Study Pain Effects Scale (PES) (Fischer, Rudick, Cutter, & Reingold, 1999) to assess chronic pain. After controlling for demographic variables and disability severity, subjective pain accounted for significant variance in PM, particularly for time-based intentions over sustained delay periods. These data accord well with assertions that pain may degrade ability to remember new intentions, and suggests that pain is associated with PM dysfunction in people with MS.

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Neurodegenerative Properties of Chronic Pain: Cognitive Decline in Patients with Chronic Pancreatitis

Cited by 50 publications

References 59 publications

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Vocal response inhibition is enhanced by anodal tDCS over the right prefrontal cortex

Pain is associated with prospective memory dysfunction in multiple sclerosis

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