Neurodegeneration in multiple sclerosis: novel treatment strategies

Abstract

In recent years it has become clear that the neuronal compartment already plays an important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course of chronic neuroinflammation is a key factor in determining long-term disability in patients. Viewing MS as both inflammatory and neurodegenerative has major implications for therapy, with CNS protection and repair needed in addition to controlling inflammation. Here, the authors' review recently elucidated molecular insights into inflammatory neuronal/axonal pathology in MS and discuss the resulting options regarding neuroprotective and regenerative treatment strategies. Neurodegeneration in multiple sclerosis: novel treatment strategiesExpert Rev. Neurother. 12(9), 1061-1077 (2012) Keywords: multiple sclerosis • neurodegeneration • neuronal injury • neuroprotection • treatment Medscape: Continuing Medical Education OnlineThis activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Expert Reviews Ltd. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at www.medscape.org/journal/expertneurothera; (4) view/print certificate. Learning objectivesUpon completion of this activity, participants will be able to:• Describe recent insights into inflammatory neuronal injury in multiple sclerosis, based on a review • Describe methods of quantification of neuronal injury in patients with multiple sclerosis, based on a review • Describe applications of these findings to treatment for patients with multiple sclerosis, based on a review

Esclerosis múltiple: aspectos inmunológicos actuales

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“…In susceptible individuals, exposing to environmental factors induces neurodegenerative autoimmune response against CNS, leading to inflammation, demyelination and neuronal injury [7]. Given the critical increase in the rate of the disease over the past two decades and considering the point that rearrangement of genetic materials cannot be responsible for such fast growth, it becomes plausible that changes in environmental factors such as nutrition and life style could have contributed to the rise in disease rates [6].…”

Use of Software Analytics of Brain MRI (with & without contrast) As Objective Metric in Neurological Disorders and Degenerative Diseases

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