“…Evolving clinical trials include both guided placement of stem/stromal elements and biological agents in orthopedic medicine and surgery, but also intravenous and central nervous system placement in a variety of complex disorders which do minimally or not respond to conventional therapy (such as Diabetes, Multiple Sclerosis, Alzheimer's disease, Parkinson's disease, Severe Limb Ischemia, Traumatic Brain Injuries, etc.) [27,28]. Early reports of improvement in chronic conditions, including pain, arthritis, damaged tendons-ligaments, low back & facet degeneration, etc., are driving many to select this option to improve surgical outcomes or avoid surgical interventions and shorten the demands for physical therapy.…”