Neurodegeneration in Mice Resulting From Loss of Functional Selenoprotein P or Its Receptor Apolipoprotein E Receptor 2

Mice Lacking Selenoprotein P and Selenocysteine Lyase Exhibit Severe Neurological Dysfunction, Neurodegeneration, and Audiogenic Seizures

“…Previous studies showed that when fed a selenium-deficient diet Sepp1 Ϫ/Ϫ mice develop extensive neurodegeneration in hindbrain regions associated with auditory and motor function, and that the brain damage can largely be prevented by feeding a high selenium diet (6). We found that the brains of selenium-supplemented Scly…”

“…The somatosensory cortex and inferior colliculus were also selected because they were found to display neurodegeneration in Sepp1 Ϫ/Ϫ mice fed a selenium-deficient diet (6,18). One-way ANOVA showed a significant difference between genotypes in the inferior colliculus (F (2,11) …”

“…In mice, Sepp1 deletion results in a neurological phenotype that includes deficits in motor coordination and cognition, and increased susceptibility to seizures (3,4). Moreover, deletion of either Sepp1 or ApoER2 results in diminished brain selenium levels, and upon feeding a selenium-deficient diet both Sepp1 and ApoER2 KO mice exhibit severe neurological dysfunction and brainstem neurodegeneration (5,6).…”

Selenium status and cardiometabolic health: State of the evidence

“…69 A number of sources provide evidence of a clear connection between lipoproteins and selenium metabolism. [70][71][72][73] For example, selenoprotein P is taken up by the brain and the testes via the apolipoprotein E receptor-2, 70-72 whereas another apolipoprotein receptor, megalin, mediates its uptake by the kidney. 73 Moreover, in mouse knock-out models in which selenoprotein synthesis is compromised, both liver Apo E protein concentration, plasma cholesterol and expression of genes involved in cholesterol biosynthesis, metabolism and transport are altered, demonstrating a role for selenoproteins in the regulation of lipoprotein biosynthesis.…”

Maternal reproductive health: Expression patterns of antioxidant enzyme selenoproteins of post-implantation embryos conceived by ethanol-treated murine mothers supplemented with α-tocopherol

“…Based on histological studies and reports, SelP-/-mice fed with Se-deficient diet upon weaning exhibited neurodegeneration [8,25]. These studies support the roles of Selenium in neurogenesis.…”