NEUROCRISTOPATHY: Its Growth and Development in 20 Years

Mechanisms driving neural crest induction and migration in the zebrafish andXenopus laevis

“…[29][30][31] Neural crest derivatives occupy various positions along an organism's rostral-caudal axis and are categorized as cranial, vagal, trunk and sacral. 32 The cranial neural crest forms first and appears to be specified during gastrulation (at least in Xenopus and likely in zebrafish). More posterior neural crest form later and perhaps are subject to different inductive and migratory signals, in analogy to the mechanisms involved in the origin of trunk and tailbud dermomyotome.…”

Complementation of melanocyte development in SOX10 mutant neural crest using lineage‐directed gene transfer

“…An understanding of NC cell development is also medically important as human neurocristopathies result from defects in the development of NC cell lineages (reviewed in Bolande, 1997). Waardenburg syndrome (WS) is characterized by patchy hypopigmentation of the skin, white forelock, and deafness resulting from a lack of melanocytes.…”

Human Embryogenesis

“…Hirschsprung disease is a less common disorder of the enteric nervous system, affecting the colon in about 1/1500 children, with epidemiology very similar to pyloric stenosis: >80% males, excessive in frequency among twins, even more highly heritable than pyloric stenosis and even more rarely concordant in twins (Bolande, 1997;Jones, 1990;Kenny et al 2010;Martucciello, 1977;Moore, 2006;Shahar & Shinawi, 2003;Tam, 1986;Tam & Garcia-Barceló, 2009;Templeton, 1977).…”