Mechanisms driving neural crest induction and migration in the zebrafish and<i>Xenopus laevis</i>

Klymkowsky, Michael W.; Rossi, Christy Cortez; Artinger, Kristin

doi:10.4161/cam.4.4.12962

Cited by 39 publications

(27 citation statements)

References 249 publications

(222 reference statements)

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“…However, chicken is the most and best studied model organism given it easiness and hardiness to manipulate. Thus studies in chicken trunk neural crest migration range from gain/loss-of-function experiments to transplants to beads and ex ovo cultures (Ahlgren and Bronner-Fraser, 1999; Giovannone et al, 2012; Klymkowsky et al, 2010; McKeown et al, 2005; Moore et al, 2013; Tucker, 2001). Finally, the best live imaging research on trunk neural crest migration has been done in chicken (Kulesa et al, 2013; McKinney and Kulesa, 2011; Wynn et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Chicken trunk neural crest migration visualized with HNK1

et al. 2015

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The development of the nervous system involves cells remaining within the neural tube (CNS) and a group of cells that delaminate from the dorsal neural tube and migrate extensively throughout the developing embryo called neural crest cells (NCC). These cells are a mesenchymal highly migratory group of cells that give rise to a wide variety of cell derivatives: melanocytes, sensory neurons, bone, Schwann cells, etc. But not all NCC can give rise to all derivatives, they have fate restrictions based on their axial level of origin: cranial, vagal, trunk and sacral. Our aim was to provide a thorough presentation on how does trunk neural crest cell migration looks in the chicken embryo, in wholemount and in sections using the unique chicken marker HNK1. The description presented here makes a good guideline for those interested in viewing trunk NCC migration patterns. We show how before HH14 there are few trunk NCC delaminating and migrating, but between HH15 through HH19 trunk NCC delaminate in large numbers. Melanocytes precursors begin to enter the dorsolateral pathway by HH17. We found that by HH20 HNK1 is not a valid good marker for NCC and that HNK1 is a better marker than Sox10 when looking at neural crest cells morphology and migration details.

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Section: Discussionmentioning

confidence: 99%

Chicken trunk neural crest migration visualized with HNK1

et al. 2015

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“…The timing and expression of essential molecular markers governing each stage of SC development are well described and are remarkably conserved between mouse and zebrafish (Figure 1). In both species, neural crest cells expressing Sox9 and Sox10 delaminate from the neural tube during early embryonic development (embryonic day (E) 8.5 in mouse, 12.5 hours post-fertilization (hpf) in zebrafish) and migrate into the periphery (Kelsh 2006; Klymkowsky et al, 2010; Erickson and Weston, 1983). SC precursors expressing Erbb2 and Erbb3 develop from a subset of migrating neural crest cells (E12–13 in mouse, 18–48 hpf in zebrafish) and continue to co-migrate along pathfinding axons (Jessen and Mirsky, 2005; Gilmour et al, 2002; Lyons et al, 2005).…”

Section: Schwann Cell Development and Myelinationmentioning

confidence: 99%

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

Ackerman

Monk

2016

Brain Research

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Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent of the zebrafish model system in the late twentieth century, the use of this genetically tractable, yet simpler vertebrate for studying myelination has steadily increased. In this review, we compare myelinating glial cell biology during development and regeneration in zebrafish and mouse and enumerate the advantages and disadvantages of using each model to study myelination.

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“…NC cell chain migration has been reported in a number of model systems including chick, zebrafish and mouse [11–14]. NC cell chains in living chick embryos have been observed to persist in vivo for at least 10–15 h over distances up to 600 µm.…”

Section: Introductionmentioning

confidence: 99%

Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour

Wynn

Kulesa

Schnell

2012

J. R. Soc. Interface.

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Follow-the-leader chain migration is a striking cell migratory behaviour observed during vertebrate development, adult neurogenesis and cancer metastasis. Although cell–cell contact and extracellular matrix (ECM) cues have been proposed to promote this phenomenon, mechanisms that underlie chain migration persistence remain unclear. Here, we developed a quantitative agent-based modelling framework to test mechanistic hypotheses of chain migration persistence. We defined chain migration and its persistence based on evidence from the highly migratory neural crest model system, where cells within a chain extend and retract filopodia in short-lived cell contacts and move together as a collective. In our agent-based simulations, we began with a set of agents arranged as a chain and systematically probed the influence of model parameters to identify factors critical to the maintenance of the chain migration pattern. We discovered that chain migration persistence requires a high degree of directional bias in both lead and follower cells towards the target. Chain migration persistence was also promoted when lead cells maintained cell contact with followers, but not vice-versa. Finally, providing a path of least resistance in the ECM was not sufficient alone to drive chain persistence. Our results indicate that chain migration persistence depends on the interplay of directional cell movement and biased cell–cell contact.

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Mechanisms driving neural crest induction and migration in the zebrafish andXenopus laevis

Cited by 39 publications

References 249 publications

Chicken trunk neural crest migration visualized with HNK1

Chicken trunk neural crest migration visualized with HNK1

The scales and tales of myelination: using zebrafish and mouse to study myelinating glia

Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour

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