Neurocognitive Outcome in Very Long‐Term Survivors of Childhood Acute Lymphoblastic Leukemia After Treatment with Chemotherapy Only

Abstract

Very long-term survivors of childhood ALL treated exclusively with chemotherapy showed no impairment in general intellectual ability, but significantly poorer performance in several neurocognitive domains than comparison peers. However, no associations emerged between neurocognitive impairment and treatment burden.

Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

“…Among young adult survivors of childhood ALL who were treated with chemotherapy-only and who were at least ten years from diagnosis, the frequency of severe impairment in executive function was eight times higher than that seen in the general population [4]. Although higher plasma concentration of methotrexate and homocysteine are associated with lower executive function in long-term adolescent survivors [8], some studies failed to identify treatment- or disease-related factors associated with executive function problems [9]. …”

Training systems for correction of cognitive impairments in children and adolescents after antineoplastic therapy for malignant neoplasms of the central nervous system

“…Введение До 80 % излеченных от злокачественных новообразований пациентов являются инвалидами детства или становятся ими во взрослом возрасте, т. к. одной из нерешенных в настоящее время проблем остается возникнове-ние в процессе или после окончания лечения опухолей ЦНС перманентных и поздних осложнений терапии [1,2,3,4].…”

Fertility Among Female Survivors of Childhood, Adolescent, and Young Adult Cancer: Protocol for Two Pan-European Studies (PanCareLIFE) (Preprint)

“…These institutions, referred to as data providers (DPs), provide data from 16 different institutional cohorts in total. Some of these DPs have previously collected their data, as part of a local fertility study [3,8,[17][18][19][20][21], while other DPs collect their data specifically during the PanCareLIFE project. All survivors included in the PanCareLIFE female fertility cohort study are treated between 1963 and 2014.…”