Neurocognitive functioning in patients recently diagnosed with bipolar disorder

Hellvin, Tone; Sundet, Kjetil; Simonsen, Carmen; Aminoff, Sofie Ragnhild; Lagerberg, Trine Vik; Andreassen, Ole A.; Melle, Ingrid

doi:10.1111/j.1399-5618.2012.01004.x

Cited by 80 publications

(87 citation statements)

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“…However, recent studies also show an increased prevalence of minor physical anomalies (Akabaliev et al, 2011), and that cognitive and social dysfunctions are present already at first treatment in patients with bipolar disorder (Torres et al, 2010;Hellvin et al, 2012Hellvin et al, , 2013.…”

Section: Introductionmentioning

confidence: 99%

Environmental factors during adolescence associated with later development of psychotic disorders – A nested case-control study

Bratlien

Øie

Haug

et al. 2014

Psychiatry Research

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a b s t r a c tEtiologies of psychotic disorders (schizophrenia and bipolar disorder) are conceptualized as interplay between genetic and environmental factors. The adolescent period is characterized by changes in social roles and expectations that may interact with biological changes or psychosocial stressors. Few studies focus on the adolescents' own reports of perceived risk factors. To assess differences at age 16 between persons who later develop psychotic disorders ("Confirmed Psychosis", CP) and their class-mates ("Population Controls", PC) we collected information on: (1) Social support factors (size of social network and expectancies of social support from friends), (2) Cognitive functioning (concentrating in the classroom, actual grades and expectancies of own academic achievements) and (3) Problems and stressors in families (illness or loss of work for parents), and in relationship with others (exposure to bullying, violence or sexual violation). Self-reported data from students at 15-16 years of age were linked to the case-registers from the "Thematically Organized Psychosis (TOP) Study". The CP group reported more economic problems in their families, smaller social network and lower academic expectation than the PC group. The results support the notion that long-term socioeconomic stressors in adolescence may serve as risk factors for the development of psychotic disorders.

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Section: Introductionmentioning

confidence: 99%

Environmental factors during adolescence associated with later development of psychotic disorders – A nested case-control study

Bratlien

Øie

Haug

et al. 2014

Psychiatry Research

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“…First-episode mania patients were found to have less neurocognitive deficits in psychomotor speed, attention, learning and memory, executive function, and IQ compared with multiple-episode patients (Hellvin et al, 2012;Van Gorp et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Attention impairment in bipolar disorder: A systematic review.

Camelo

Velasques

Ribeiro

et al. 2013

Psychology & Neuroscience

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Bipolar disorder (BD) has been associated with marked cognitive impairment, including euthymic periods. Attention is among the most compromised functions in BD. Changes related to learning, memory, and visuospatial abilities can be derived from these attention impairments. The objective of this article is to review the scientific literature on the performance of BD patients in attention tests. A systematic review was performed of controlled studies that assessed attention in patients diagnosed with BD aged between 18 and 65 years. The databases included Medline, LILACS, Cochrane Library, Institute for Scientific Information Web of Knowledge, and Scientific Electronic Library Online (SciELO), and the search encompassed the period from 2008 to 2013. Only studies that had a minimum sample of 10 patients were included. A total of 110 articles fulfilled the inclusion criteria. Compared with healthy control subjects, bipolar patients showed poorer attention performance. Compared with other mental disorders, BD was associated with poorer performance than unipolar depression but better performance than schizophrenia. When bipolar patients in different phases of the disease were compared with one another, the performance of euthymic patients was similar to or better than patients in a depressive state; moreover, manic patients performed worse than depressive patients. Attention is significantly impaired in BD. Attention impairment in BD is milder than in schizophrenia but greater than in unipolar depression. Attention impairment is possibly more severe in manic and depressed episodes than in euthymic periods

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“…Es un hecho bien conocido y comprobado a lo largo de décadas de investigación, que, en comparación con la población normal, los pacientes con trastornos mentales graves presentan un aspecto común: los déficit cognitivos, sean dichos trastornos parte del espectro psicótico (Bleuler, 1911;Crawford, Obonsawin y Bremner 1993;Green, 1996;Godbout, Limoges, Allard, Braun, Stip, 2007;Aubin, Stip, Gélinas, Rainville, Chapparo, 2009) o afectivo (martínez- Arán et al 2004;Harvey, Wingo, Burdick y Baldessarini, 2010;Hellvin et al 2012). Las personas con esquizofrenia tienen una ejecución de 0,8 a 1,5 desviaciones típicas por debajo de los controles sanos en muchos dominios cognitivos como, por ejemplo, en tareas de atención, memoria verbal o funciones ejecutivas (Heinrichs y Zakzanis, 1998).…”

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Programa de rehabilitación neurocognitiva para pacientes con trastorno mental grave

Sutu¹,

Moro-Ipola²,

Mezquita³

2015

AgoraSalut

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ResumenIntroducción: El deterioro cognitivo es un síntoma central en trastornos mentales graves como la esquizofrenia y el trastorno bipolar, con un impacto negativo en el funcionamiento psicosocial. En la literatura científica reciente se destaca la importancia de encontrar un método no farmacológico que mejore estas funciones. El objetivo del presente estudio es dar un primer apoyo empírico a la eficacia del programa de rehabilitación cognitiva, «Pon en forma tus neuronas», desarrollado para tratar las alteraciones cognitivas en pacientes con trastorno mental grave. Método: La muestra está formada por 6 hombres y 2 mujeres, con una edad media de 35,9 años (Dt = 8,47). Los diagnósticos son de esquizofrenia en 6 casos, 1 síndrome de Asperger y otro trastorno esquizoafectivo. Se administró una batería de pruebas neuropsicológicas antes y después del tratamiento neurocognitivo. Se calcularon correlaciones, pruebas T y las des de Cohen entre las puntuaciones obtenidas en las pruebas antes y después del tratamiento. Resultados: Los resultados mostraron correlaciones significativas y en la dirección esperada entre la evaluación pre-y el postratamiento en aVlt, Figura de Rey, y Clave de números y Dígitos del wais-iii. Además, encontramos tamaños del efecto moderados para el aVlt a largo plazo (0,73) y tamaños del efecto elevados en Figuras Incompletas del wais (0,92). Conclusiones: Aunque se trata de un estudio piloto con una muestra muy pequeña, los resultados indican que el tratamiento neurocognitivo mejora las funciones de percepción y memoria (de trabajo, visual y verbal) en personas con trastorno mental grave.Palabras clave: trastorno mental grave, rehabilitación neurocognitiva, alteraciones cognitivas, funciones cognitivas. abstract Introduction: Cognitive impairment is a core symptom in severe mental disorders like schizophrenia and bipolar disorders, with a significant impact on psychosocial function. Recent scientific literature on this topic points out the importance of discovering a nonpharmacological treatment to improve these functions. The objective of the present study is to bring empirical evidence on the efficacy of a cognitive remediation program, «Pon en forma tus neuronas», developed to treat cognitive impairment in patients suffering from a severe mental disorder. method: The sample was formed by six men and two women with a median age of 35,9 years old (SD= 8,47). Six of them suffer from Schizophrenia, whereas one suffers from Asperger's Syndrome and another one from Schizoaffective Disorder. They were administered various neuropsychological tests pre» and post» treatment. The difference between the baseline and post treatment measures was evaluated by correlation analysis and Cohen's «ds». Results: Baseline and post-treatment results correlated significantly in the expected direction in aVlt, Rey Figure Test, Numbers key and wais-iii Numbers. Moreover, moderate effect size was found for long term aVlt (0.73) and for «Incomplete figures» (0.92). Conclusion: Although we stay in front of a pilot st...

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Neurocognitive functioning in patients recently diagnosed with bipolar disorder

Abstract: Neurocognitive dysfunction is present in early BD and is clinically significant for a proportion of patients. Our findings also suggest that neurocognitive dysfunction may increase with illness progression.

Cited by 80 publications

References 40 publications

Environmental factors during adolescence associated with later development of psychotic disorders – A nested case-control study

Environmental factors during adolescence associated with later development of psychotic disorders – A nested case-control study

Attention impairment in bipolar disorder: A systematic review.

Programa de rehabilitación neurocognitiva para pacientes con trastorno mental grave

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