Neurocognitive function of pediatric heart transplant recipients

Haavisto, Anu; Korkman, Marit; Jalanko, Hannu; Holmberg, Christer; Qvist, Erik

doi:10.1016/j.healun.2010.02.008

Cited by 22 publications

(24 citation statements)

References 29 publications

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“…Younger age at transplant was associated with higher scores on measures of processing speed, and full‐scale IQ and processing speed were negatively correlated with total months on dialysis prior to transplant. Results for heart transplant recipients follow a similar pattern, with low‐average mean full‐scale IQ scores and a higher proportion of children obtaining scores in the below average range compared with healthy norms . In one study of 55 primary school children who had undergone heart transplantation in infancy, mean IQ scores were in the low‐average range .…”

Section: Neuropsychological Effectsmentioning

confidence: 76%

“…Studies typically have small sample sizes and are cross-sectional in nature. Comparison of study results reveals few consistent patterns but impaired visual-motor integration has been identified in several groups of patients (39,57,59,62,63). In a number of studies, working memory was found to be impaired, which it has been suggested was due to the toxicity of corticosteroids to the hippocampus, a structure important for learning and memory (39,47,50,52).…”

Section: Other Areas Of Functioningmentioning

confidence: 95%

“…In a number of studies, working memory was found to be impaired, which it has been suggested was due to the toxicity of corticosteroids to the hippocampus, a structure important for learning and memory . However, this is not a consistent finding—for example, in a small (n = 18) study of liver recipients children obtained lower visual‐motor integration scores but performance on tasks assessing attention, learning and memory was in the normal range . There have been some attempts to look at correlates of poorer function—for example, in a study of 50 renal patients, verbal working memory and complex (but not simple) auditory attention were associated with poorer renal function .…”

Section: Neuropsychological Effectsmentioning

confidence: 99%

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Post‐transplant adjustment – The later years

Fredericks

Zelikovsky

Aujoulat

et al. 2014

Pediatric Transplantation

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As survival rates for pediatric solid organ transplantation have continued to improve, researchers and health care providers have increasingly focused on understanding and enhancing the health related quality of life (HRQOL) and psychosocial functioning of their patients. This manuscript reviews the psychosocial functioning of pediatric transplant recipients during the “later years”, defined as more than 3 years post-transplant, and focuses on the day-to-day impact of living with a transplant after the immediate period of adjustment and early years after surgery. Key topics reviewed include health-related quality of life, cognitive functioning, impact on the family, regimen adherence, and transition of responsibility for self-management tasks. Overall, pediatric transplant recipients evidence impairment in HRQOL, neuropsychological outcomes, and family functioning as compared to non-transplant recipients. However, the degree of impairment is influenced by a variety of factors including, disease severity, age, solid organ type, and study methodologies. Studies are limited by small samples, cross-sectional design, and the lack of universal assessment battery to allow for comparisons across solid organ populations. Areas for future research are discussed.

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Section: Neuropsychological Effectsmentioning

confidence: 76%

Section: Other Areas Of Functioningmentioning

confidence: 95%

Section: Neuropsychological Effectsmentioning

confidence: 99%

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Post‐transplant adjustment – The later years

Fredericks

Zelikovsky

Aujoulat

et al. 2014

Pediatric Transplantation

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“…Analyses of our small cohort of heart‐transplanted pediatric patients indicate that the general cognitive development of children who have received VAD support prior to HTx does not differ from other age‐matched HTx patients. However, we have previously shown that pediatric HTx patients, in general, have lower mean PIQ and more visuoconstructive and visuomotor difficulties compared with population norms . Neurological or neuropsychological follow‐up protocol for all pediatric HTx patients is therefore warranted.…”

Section: Discussionmentioning

confidence: 97%

Outcome of pediatric heart transplantation recipients treated with ventricular assist device

Jahnukainen

Rautiainen

Mattila

et al. 2012

Pediatric Transplantation

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This study was conducted to evaluate the long-term prognosis of pediatric HTx patients treated with VAD before transplantation. The clinical data of six patients bridged to HTx with Berlin Heart EXCOR pediatric device were analyzed retrospectively. Information about graft function, CA results, and EMB findings as well as appearance DSA was collected. Also, information about growth and cognitive function was analyzed. These findings were compared with age-, gender-, and diagnosis-matched HTx patients. During the median follow-up time of four and half yr after HTx, the prognosis including graft function, number of rejection episodes, and incidence of coronary artery vasculopathy, growth and cognitive development did not differ between VAD-bridged HTx patients compared with control patients. In both groups, one patient developed positive DSA titer after HTx. Our single-center experience suggests that the prognosis of pediatric HTx patients treated with VAD before transplantation is not inferior to that of other HTx patients.

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“…Viele Patienten zeigen eine graduierte Intelligenzminderung und neurologische Teildefizite und bedürfen daher einer begleitenden neurologischen, krankengymnastischen und kognitiven Förderung [11,21].…”

Section: Neurologische Komplikationenunclassified