“…Since 1997 less than 10 lung transplants per year have been performed in infants worldwide. In Europe, lung transplants are only performed in rare cases in children younger than 2-3 years of age with a chronic or acute but irreversible respiratory insuffi ciency [ 20 ] . Donor organ shortage, limited number of centers, reduced quality of life after lung transplantation, and a high 5-year mortality rate of 50 % in face of the young age limits the application of this option [ 18 ] .…”
More experience in the treatment of newborns with ABCA3 gene mutations is needed. Randomized, prospective evaluation of the different therapeutic approaches in a specific registry may improve prognosis and treatment of affected individuals.
“…Since 1997 less than 10 lung transplants per year have been performed in infants worldwide. In Europe, lung transplants are only performed in rare cases in children younger than 2-3 years of age with a chronic or acute but irreversible respiratory insuffi ciency [ 20 ] . Donor organ shortage, limited number of centers, reduced quality of life after lung transplantation, and a high 5-year mortality rate of 50 % in face of the young age limits the application of this option [ 18 ] .…”
More experience in the treatment of newborns with ABCA3 gene mutations is needed. Randomized, prospective evaluation of the different therapeutic approaches in a specific registry may improve prognosis and treatment of affected individuals.
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