Neurocognitive and functional heterogeneity in depressed youth

Baller, Erica B.; Kaczkurkin, Antonia N.; Sotiras, Aristeidis; Adebimpe, Azeez; Bassett, Danielle S.; Calkins, Monica E.; Chand, Ganesh; Cui, Zaixu; Gur, Raquel E.; Gur, Ruben C.; Linn, Kristin A.; Moore, Tyler M.; Roalf, David R.; Varol, Erdem; Wolf, Daniel H.; Xia, Cedric Huchuan; Davatzikos, Christos; Satterthwaite, Theodore D.

doi:10.1038/s41386-020-00871-w

Cited by 12 publications

(4 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adult literature consistently reports altered FPN functioning in depression and anxiety ( Kaiser et al, 2015 ; Sylvester et al, 2012 ), and these differences can also be identified in development. Previous fMRI research has linked variations in frontoparietal network function with phenotypic heterogeneity in youth depression ( Baller et al, 2020 ) and anxiety disorders ( Fitzgerald et al, 2013 ). As a next step, it will be important to study whether frontoparietal coupling could be used as a biomarker for sex differences in psychopathology.…”

Section: Discussionmentioning

confidence: 99%

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

et al. 2022

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…This implies that the 22qDup group had more difficulty processing spatial information than information related to non‐verbal reasoning. Lastly, while there have been a handful of studies examining associations between brain structure and/or function and Penn‐CNB scores (Baller et al, 2021; Fabri et al, 2021; Huang et al, 2020; Khan et al, 2022; Prasad et al, 2022), and the tests have been validated with functional neuroimaging showing specificity of regional activation (Roalf et al, 2014), the precise neural correlates of each Penn‐CNB test has yet to be determined, which limits the ability to infer information about neurodevelopment from the results presented.…”

Section: Discussionmentioning

confidence: 99%

Distinct neurocognitive profiles and clinical phenotypes associated with copy number variation at the 22q11.2 locus

O'Hora,

Kushan‐Wells,

Schleifer

et al. 2023

Autism Research

Self Cite

View full text Add to dashboard Cite

Rare genetic variants that confer large effects on neurodevelopment and behavioral phenotypes can reveal novel gene‐brain‐behavior relationships relevant to autism. Copy number variation at the 22q11.2 locus offer one compelling example, as both the 22q11.2 deletion (22qDel) and duplication (22qDup) confer increased likelihood of autism spectrum disorders (ASD) and cognitive deficits, but only 22qDel confers increased psychosis risk. Here, we used the Penn Computerized Neurocognitive Battery (Penn‐CNB) to characterized neurocognitive profiles of 126 individuals: 55 22qDel carriers (MAge = 19.2 years, 49.1% male), 30 22qDup carriers (MAge = 17.3 years, 53.3% male), and 41 typically developing (TD) subjects (MAge = 17.3 years, 39.0% male). We performed linear mixed models to assess group differences in overall neurocognitive profiles, domain scores, and individual test scores. We found all three groups exhibited distinct overall neurocognitive profiles. 22qDel and 22qDup carriers showed significant accuracy deficits across all domains relative to controls (episodic memory, executive function, complex cognition, social cognition, and sensorimotor speed), with 22qDel carriers exhibiting more severe accuracy deficits, particularly in episodic memory. However, 22qDup carriers generally showed greater slowing than 22qDel carriers. Notably, slower social cognition speed was uniquely associated with increased global psychopathology and poorer psychosocial functioning in 22qDup. Compared to TD, 22q11.2 copy number variants (CNV) carriers failed to show age‐associated improvements in multiple cognitive domains. Exploratory analyses revealed 22q11.2 CNV carriers with ASD exhibited differential neurocognitive profiles, based on 22q11.2 copy number. These results suggest that there are distinct neurocognitive profiles associated with either a loss or gain of genomic material at the 22q11.2 locus.

show abstract

“…The Penn computerised neurocognitive battery (CNB) is validated and widely used and includes multiple tests to assess four cognitive domains: executive function, episodic memory, complex cognition and social cognition. The CNB has been validated in different populations, including children and adults with psychiatric disorders (Gur et al 2015;Baller et al 2021;Kantor et al 2022), as well as in individuals with 22q11.2DS (Gur et al 2014;Yi et al 2016;Tang et al 2017a). Thus, having the CNB validated for remote assessments for individuals with 22q11.2DS would be beneficial for scientific advancement by offering a tool that can be deployed in both research and clinical settings, as the CNB can provide a proxy for IQ (Gur et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“…2015; Baller et al . 2021; Kantor et al . 2022), as well as in individuals with 22q11.2DS (Gur et al .…”

Section: Introductionmentioning

confidence: 99%

Remote assessment of the Penn computerised neurocognitive battery in individuals with 22q11.2 deletion syndrome

White,

Hillman,

Ruparel

et al. 2024

J intellect Disabil Res

View full text Add to dashboard Cite

BackgroundNeurocognitive functioning is an integral phenotype of 22q11.2 deletion syndrome relating to severity of psychopathology and outcomes. A neurocognitive battery that could be administered remotely to assess multiple cognitive domains would be especially beneficial to research on rare genetic variants, where in‐person assessment can be unavailable or burdensome. The current study compares in‐person and remote assessments of the Penn computerised neurocognitive battery (CNB).MethodsParticipants (mean age = 17.82, SD = 6.94 years; 48% female) completed the CNB either in‐person at a laboratory (n = 222) or remotely (n = 162).ResultsResults show that accuracy of CNB performance was equivalent across the two testing locations, while slight differences in speed were detected in 3 of the 11 tasks.ConclusionsThese findings suggest that the CNB can be used in remote settings to assess multiple neurocognitive domains.

show abstract

Neurocognitive and functional heterogeneity in depressed youth

Cited by 12 publications

References 76 publications

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Distinct neurocognitive profiles and clinical phenotypes associated with copy number variation at the 22q11.2 locus

Remote assessment of the Penn computerised neurocognitive battery in individuals with 22q11.2 deletion syndrome

Contact Info

Product

Resources

About