Neurocognition in bipolar disorders—A closer look at comorbidities and medications

Balanzá‐Martínez, Vicent; Selva, Gabriel; Martínez‐Arán, Anabel; Prickaerts, Jos; Salazar, José; González‐Pinto, Ana; Vieta, Eduard; Tabarés‐Seisdedos, Rafael

doi:10.1016/j.ejphar.2009.10.018

Cited by 115 publications

(91 citation statements)

References 124 publications

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“…Small sample-sized studies, especially regarding BD II patients, might have determined type I or type II errors, so larger samples should be analysed in order to reach firmer conclusions. Some studies were conducted in unmedicated patients, since treatments may play an important role in cognitive deficits, although available data regarding the effects of mood-stabilizers on cognition are inconsistent, possibly due to methodological issues (Goldberg & Chengappa, 2009 ;Vieta, 2009 ;Balanzá-Martínez et al 2010). The cognitive deficits observed in BD are not simply the effect of medication since these same cognitive deficits have been observed in unaffected relatives (Arts et al 2008 ;Bora et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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Background. There is evidence that bipolar disorder (BD) is associated with significant neurocognitive deficits and this occurs in individuals with BD type I (BD I) and with BD type II (BD II). Only a few studies have focused on cognitive impairment in BD II. The aim of this study was to describe the pattern of cognitive impairment in patients with BD II, in order to identify specific cognitive deficits that distinguish BD II from BD I patients as well as from healthy subjects.Method. We performed a systematic review of the literature of neuropsychological studies of BD II published between 1980 and July 2009. Fourteen articles fulfilled the inclusion criteria and were included in this review.Results. Main cognitive deficits found in BD II include working memory and some measures of executive functions (inhibitory control) and approximately half of the studies also detected verbal memory impairment.Conclusions. There are subtle differences between the two subtypes regarding cognition. This may suggest neurobiological differences between the two subgroups which will be helpful in order to determine cognitive endophenotypes in BD subtypes.

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Section: Discussionmentioning

confidence: 99%

Are bipolar II patients cognitively impaired? A systematic review

et al. 2011

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“…Impaired executive functions in bipolars shown in tests might be the feature of bipolar disorder regardless the effects of medication [87]. The contributions of bipolar disorder traitstate cognitive impairment and medications is very complicated to distinguish as well as control [78]. Clinicians treating BD patients should take it into account in prescribing medications for long-term prophylaxis.…”

Section: Factors Associated With Cognitive Deficitsmentioning

confidence: 99%

“…These might support statement that lithium treatment is associated with a preservation of cognitive functions in ER group. According to literature review [78] neurostructural changes in BD would be hypothetically influenced by the neuroprotective/neurotrophic properties of lithium. These findings are interesting because the pathophysiology of BD involves structural and functional changes in cortical and limbic networks implicated in the regulation of mood and cognition.…”

Section: Factors Associated With Cognitive Deficitsmentioning

confidence: 99%

Cognitive Functions in Euthymic Bipolar Patients and Lithium

Suwalska¹,

Łojko²

2013

Mood Disorders

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“…Although the individuals included into the study were considered to be remitted by leading highly qualified doctors and assessed by other an independent psychiatrist according to standard psychiatric rating scales, the patients' states of remission could vary between different individuals, due to the lack of a precise set of criteria for remission in bipolar individuals. Because the majority of patients were in polytherapy, the assessment of the influence of antipsychotic medication on cognition is very Archives of Psychiatry and Psychotherapy, 2013; 2 : [5][6][7][8][9][10][11][12] limited. Lastly, because some of the investigated patients self-reported incomplete compliance, it is worth to indicate that this fact could additionally influence on the results.…”

Section: Limitationsmentioning

confidence: 99%

“…The impact of pharmacological treatment is relevant among the many different factors that influence on the cognitive functioning of bipolar patients [7]. Although cognitive dysfunctions are observed even in unmedicated bipolar individuals, different types of pharmacological treatment may lead to additional cognitive impairment [8].…”

Section: Introductionmentioning

confidence: 99%

Association of different cognitive domains with the lifetime history of psychosis and reported antipsychotic- treatment adverse events in bipolar disorders.

Kałwa

Piróg-Balcerzak²,

Święcicki³

2013

Arch Psych Psych

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Aim of the studyThe present work aimed to assess the association between cognitive functions, the lifetime occurrence of psychotic symptoms, and reported adverse effects of antipsychotic treatments in patients with bipolar disorders.Subject or material and methodsIn the present work, 44 bipolar disorder inpatients hospitalized in the Affective Disorders Unit of the Institute of Psychiatry and Neurology in Warsaw, were investigated. All of them met the criteria of remission and were prepared for release from the hospital unit. Twenty-two patients were hospitalized in the manic stage of the illness, and 22 were in the depressive stage of illness. Both groups were assessed using adequate psychiatric rating scales (HDRS or YMRS and CAMRS) and neuropsychological tests (WCST, TMT, Stroop Test and Verbal Fluency Test).ResultsPatients who had a prior history of psychotic symptoms had poorer verbal functioning in comparison to subjects without such a history. However, individuals hospitalized in the manic state of disease, and who reported more adverse events after antipsychotic medication during the whole course of illness, had worse results in some parameters of executive function measurements in the WCST test, namely occurring in a greater percentage of nonperseverative errors and a lower number of completed categories.DiscussionGenerally the results confirm findings according to which, patients with the history of psychosis performe worse on neurocognitive tasks. However, the nature of dysfunctions found, generates questions about its relations with the experience of psychosis and antipsychotic treatment.ConclusionsDifferent aspects of cognitive dysfunctions may be related to the experience of psychosis and antipsychotic treatment in patients with bipolar disorders.

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Neurocognition in bipolar disorders—A closer look at comorbidities and medications

Cited by 115 publications

References 124 publications

Are bipolar II patients cognitively impaired? A systematic review

Are bipolar II patients cognitively impaired? A systematic review

Cognitive Functions in Euthymic Bipolar Patients and Lithium

Association of different cognitive domains with the lifetime history of psychosis and reported antipsychotic- treatment adverse events in bipolar disorders.

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