Cognitive Functions in Euthymic Bipolar Patients and Lithium

Suwalska, Aleksandra; Łojko, Dorota

doi:10.5772/55126

Cited by 2 publications

(4 citation statements)

References 96 publications

(154 reference statements)

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“…The tests were described in detail in our previous paper [ 14 ]. The Trail Making Test (TMT) consists of two parts.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive impairment, and especially executive dysfunction, has been recognized in BD patients. They experience neuropsychological disturbances during manic and depressive episodes and during remission periods [ 14 – 16 ]. Several metaanalyses [ 17 – 23 ] have provided evidence for trait deficits in verbal memory, and learning, executive functions, working memory, and response inhibition in remitted bipolar patients.…”

Section: Introductionmentioning

confidence: 99%

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Sex Dependence of Cognitive Functions in Bipolar Disorder

Suwalska

Łojko

2014

The Scientific World Journal

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The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls in the spatial memory and planning as well as verbal fluency tests. We detected a gender-related imbalance in the SWM results. Deficits in SWM were observed in male-only comparisons but not in female-only comparisons. The SWM scores were significantly poorer in male patients than in male controls. In female-only comparisons, female patients did not have significantly poorer SWM results in any category than their controls. Bipolar women scored worse in some other tests. The present study points to the different patterns of neuropsychological disturbances in female and male patients and suggests that sex-dependent differences should be taken into account in order to tailor the therapeutic intervention aimed at the improvement of cognitive functions.

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“…The tests were described in detail in our previous paper [ 14 ]. The Trail Making Test (TMT) consists of two parts.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Dependence of Cognitive Functions in Bipolar Disorder

Suwalska

Łojko

2014

The Scientific World Journal

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“…7 Another study found that the bipolar patients in remission seems to be both affectively disturbed and have impaired working memory. 8 study have shown subtle deficits were present in attention and working memory during euthymic period of bipolar illness but those deficits weren't statistically significant. 9 Study of neuro-cognitive performance in the euthymic phase of bipolar disorder have demonstrated a perseveration of neuro-cognitive impairment in a number of areas like impairment in the domains of motor speed, as well as verbal learning, and several measures of memory(verbal, visual and working memory).…”

Section: Introductionmentioning

confidence: 81%

“…Euthymia was defined as score of <7 on the 17item Hamilton Depression Rating Scale (HAMD17) 7 and a score of <7 on the Young Mania Rating Scale (YMRS) on the day of study. 12 For the control group, 40 people matched on individual basis with euthymic bipolar patients for age, gender and years of education were recruited from non relative friends of the patient, staffs working at the mental hospital or students volunteering at the mental hospital with no current or past history of any Psychiatric disorder. Absence of psychopathology was concluded after evaluation from two consultant psychiatrists and if agreed that the control subject is free from any psychiatric morbidity.…”

Section: Methodsmentioning

confidence: 99%

Working Memory Impairment in Euthymic State of Bipolar Disorder

Jha

Joshi²,

Kattel³

et al. 2019

J Psychiatr Assoc Nepal

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Introduction: Cognitive deficits in bipolar disorders persist after the subsidence of active symptoms. This study was carried out to assess the working memory of patients with bipolar disorder in euthymic state. Material And Method: Forty euthymic bipolar patients attending a tertiary care mental hospital with equal number of matched controls in terms of age, sex and education were included in the study. Working memory assessments was done using WAIS-III digit span subtest. Results: The mean of total digit span test for case group was 8.48±2.04 similarly it was 10.33±2.32 for the controls. The result showed that the mean digit span of cases and control groups are significantly different (p value of < 0.01). The Pearsons correlation between the clinical variables and working memory test in euthymic bipolar patients (case group) was found that the total score for digit span test was negatively correlated with all other clinical variables However, this correlation was found to be non-significant. Conclusion: The working memory impairment persists in remitted bipolar disorder patients and this may represent underlying trait abnormality not the state abnormality.

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Cognitive Functions in Euthymic Bipolar Patients and Lithium

Cited by 2 publications

References 96 publications

Sex Dependence of Cognitive Functions in Bipolar Disorder

Sex Dependence of Cognitive Functions in Bipolar Disorder

Working Memory Impairment in Euthymic State of Bipolar Disorder

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